ENSG00000153094


Homo sapiens

Features
Gene ID: ENSG00000153094
  
Biological name :BCL2L11
  
Synonyms : BCL2L11 / BCL2 like 11 / O43521
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q13
Gene start: 111119378
Gene end: 111168447
  
Corresponding Affymetrix probe sets: 1553088_a_at (Human Genome U133 Plus 2.0 Array)   1553096_s_at (Human Genome U133 Plus 2.0 Array)   1555372_at (Human Genome U133 Plus 2.0 Array)   1558143_a_at (Human Genome U133 Plus 2.0 Array)   208536_s_at (Human Genome U133 Plus 2.0 Array)   222343_at (Human Genome U133 Plus 2.0 Array)   225606_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481652
Ensembl peptide - ENSP00000481423
Ensembl peptide - ENSP00000482175
Ensembl peptide - ENSP00000491422
Ensembl peptide - ENSP00000491154
Ensembl peptide - ENSP00000484360
Ensembl peptide - ENSP00000309226
Ensembl peptide - ENSP00000338374
Ensembl peptide - ENSP00000350398
Ensembl peptide - ENSP00000354879
Ensembl peptide - ENSP00000376941
Ensembl peptide - ENSP00000376943
Ensembl peptide - ENSP00000384641
Ensembl peptide - ENSP00000389225
Ensembl peptide - ENSP00000391292
Ensembl peptide - ENSP00000393781
Ensembl peptide - ENSP00000394640
Ensembl peptide - ENSP00000401662
Ensembl peptide - ENSP00000403727
Ensembl peptide - ENSP00000411137
Ensembl peptide - ENSP00000411870
Ensembl peptide - ENSP00000412892
Ensembl peptide - ENSP00000478133
Ensembl peptide - ENSP00000479714
Ensembl peptide - ENSP00000481030
NCBI entrez gene - 10018     See in Manteia.
OMIM - 603827
RefSeq - NM_138626
RefSeq - NM_001204106
RefSeq - NM_001204107
RefSeq - NM_001204108
RefSeq - NM_001204109
RefSeq - NM_001204110
RefSeq - NM_001204111
RefSeq - NM_001204112
RefSeq - NM_001204113
RefSeq - NM_006538
RefSeq - NM_138621
RefSeq - NM_138622
RefSeq - NM_138623
RefSeq - NM_138624
RefSeq - NM_138625
RefSeq - NM_138627
RefSeq - NM_207002
RefSeq - NM_207003
RefSeq - XM_005263551
RefSeq - XM_005263553
RefSeq - XM_005263554
RefSeq - XM_005263561
RefSeq - XM_011510461
RefSeq - XM_011510464
RefSeq Peptide - NP_001191035
RefSeq Peptide - NP_619531
RefSeq Peptide - NP_619532
RefSeq Peptide - NP_619533
RefSeq Peptide - NP_996885
RefSeq Peptide - NP_996886
RefSeq Peptide - NP_001191036
RefSeq Peptide - NP_001191037
RefSeq Peptide - NP_001191038
RefSeq Peptide - NP_001191039
RefSeq Peptide - NP_001191040
RefSeq Peptide - NP_001191041
RefSeq Peptide - NP_001191042
RefSeq Peptide - NP_006529
RefSeq Peptide - NP_619527
RefSeq Peptide - NP_619528
RefSeq Peptide - NP_619529
RefSeq Peptide - NP_619530
swissprot - E9PAM9
swissprot - C9J417
swissprot - A0A0C4DH20
swissprot - H7BZE5
swissprot - A0A0A0MRE7
swissprot - O43521
Ensembl - ENSG00000153094
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 O54918ENSMUSG00000027381Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR014771  Apoptosis, Bim N-terminal
 IPR015040  Bcl-x interacting, BH3 domain
 IPR017288  Bcl-2-like protein 11


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001776 leukocyte homeostasis IEA
 biological_processGO:0001782 B cell homeostasis IEA
 biological_processGO:0001783 B cell apoptotic process IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 biological_processGO:0002260 lymphocyte homeostasis IEA
 biological_processGO:0002262 myeloid cell homeostasis IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IDA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0030879 mammary gland development IEA
 biological_processGO:0032464 positive regulation of protein homooligomerization IDA
 biological_processGO:0034976 response to endoplasmic reticulum stress IDA
 biological_processGO:0035148 tube formation IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0043029 T cell homeostasis IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0043583 ear development IEA
 biological_processGO:0045787 positive regulation of cell cycle IEA
 biological_processGO:0046620 regulation of organ growth IEA
 biological_processGO:0048066 developmental pigmentation IEA
 biological_processGO:0048070 regulation of developmental pigmentation IEA
 biological_processGO:0048536 spleen development IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0048563 post-embryonic animal organ morphogenesis IEA
 biological_processGO:0060139 positive regulation of apoptotic process by virus IEA
 biological_processGO:0060154 cellular process regulating host cell cycle in response to virus IEA
 biological_processGO:0070242 thymocyte apoptotic process IEA
 biological_processGO:0071385 cellular response to glucocorticoid stimulus TAS
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IMP
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IEA
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 biological_processGO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process IEA
 biological_processGO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway TAS
 biological_processGO:1902263 apoptotic process involved in embryonic digit morphogenesis IEA
 biological_processGO:1903896 positive regulation of IRE1-mediated unfolded protein response TAS
 biological_processGO:2000271 positive regulation of fibroblast apoptotic process IDA
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IBA
 cellular_componentGO:0005741 mitochondrial outer membrane TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005868 cytoplasmic dynein complex IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0097136 Bcl-2 family protein complex IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IBA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0070840 dynein complex binding IEA


Pathways (from Reactome)
Pathway description
Activation of BIM and translocation to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
NRAGE signals death through JNK
Signaling by BRAF and RAF fusions
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimers disease models
RUNX3 regulates BCL2L11 (BIM) transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088986 DYNLL1 / P63167 / dynein light chain LC8-type 1  / complex
 ENSG00000002330 BAD / Q92934 / BCL2 associated agonist of cell death  / reaction
 ENSG00000171791 BCL2 / P10415 / BCL2, apoptosis regulator  / reaction / complex
 ENSG00000153094 O43521 / BCL2L11 / BCL2 like 11  / complex
 ENSG00000107643 MAPK8 / P45983 / mitogen-activated protein kinase 8  / reaction






 

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