ENSMUSG00000007659


Mus musculus

Features
Gene ID: ENSMUSG00000007659
  
Biological name :Bcl2l1
  
Synonyms : Bcl2l1 / Mus musculus BCL2-like 1 (Bcl2l1), transcript variant 5, mRNA. / Q64373
  
Possible biological names infered from orthology : BCL2 like 1 / Q07817
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H1
Gene start: 152780668
Gene end: 152831728
  
Corresponding Affymetrix probe sets: 10488655 (MoGene1.0st)   1420887_a_at (Mouse Genome 430 2.0 Array)   1420888_at (Mouse Genome 430 2.0 Array)   1426050_at (Mouse Genome 430 2.0 Array)   1426191_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120024
Ensembl peptide - ENSMUSP00000117716
Ensembl peptide - ENSMUSP00000134596
Ensembl peptide - ENSMUSP00000134614
Ensembl peptide - ENSMUSP00000007803
Ensembl peptide - ENSMUSP00000105445
Ensembl peptide - ENSMUSP00000114911
Ensembl peptide - ENSMUSP00000115611
NCBI entrez gene - 12048     See in Manteia.
MGI - MGI:88139
RefSeq - XM_011239260
RefSeq - NM_001289716
RefSeq - NM_001289717
RefSeq - NM_001355053
RefSeq - NM_009743
RefSeq - XM_006498609
RefSeq - XM_006498611
RefSeq - XM_006498612
RefSeq Peptide - NP_001276646
RefSeq Peptide - NP_001341982
RefSeq Peptide - NP_033873
RefSeq Peptide - NP_001276645
swissprot - A2AHX8
swissprot - Q5HZH3
swissprot - Q64373
swissprot - Q9QWX2
swissprot - A2AHX7
swissprot - A2AHX9
Ensembl - ENSMUSG00000007659
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bcl2l1ENSDARG00000008434Danio rerio
 BCL2L1ENSGALG00000006211Gallus gallus
 BCL2L1ENSG00000171552Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bcl2 / P10417 / Apoptosis regulator Bcl-2 / P10415* / BCL2, apoptosis regulator*ENSMUSG0000005732940
Bcl2l2 / P70345 / Bcl-2-like protein 2 / Q92843* / BCL2 like 2*ENSMUSG0000008968239
Bak1 / O08734 / Bcl-2 homologous antagonist/killer / Q16611* / BCL2 antagonist/killer 1*ENSMUSG0000005778917


Protein motifs (from Interpro)
Interpro ID Name
 IPR002475  Bcl2-like
 IPR003093  Apoptosis regulator, Bcl-2 protein, BH4
 IPR004725  Apoptosis regulator, Bcl-2/ BclX
 IPR013279  Apoptosis regulator, Bcl-X
 IPR020717  Apoptosis regulator, Bcl-2, BH1 motif, conserved site
 IPR020726  Apoptosis regulator, Bcl-2, BH2 motif, conserved site
 IPR020728  Apoptosis regulator, Bcl-2, BH3 motif, conserved site
 IPR020731  Apoptosis regulator, Bcl-2, BH4 motif, conserved site
 IPR026298  Blc2 family
 IPR036834  Blc2-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001836 release of cytochrome c from mitochondria IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007093 mitotic cell cycle checkpoint IEA
 biological_processGO:0007281 germ cell development IMP
 biological_processGO:0007283 spermatogenesis IGI
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:0009314 response to radiation IMP
 biological_processGO:0009566 fertilization IGI
 biological_processGO:0009615 response to virus IDA
 biological_processGO:0019050 suppression by virus of host apoptotic process ISO
 biological_processGO:0032465 regulation of cytokinesis IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0040007 growth IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0046898 response to cycloheximide IDA
 biological_processGO:0046902 regulation of mitochondrial membrane permeability IEA
 biological_processGO:0051402 neuron apoptotic process IMP
 biological_processGO:0051881 regulation of mitochondrial membrane potential IEA
 biological_processGO:0060154 cellular process regulating host cell cycle in response to virus IMP
 biological_processGO:0070584 mitochondrion morphogenesis IGI
 biological_processGO:0071230 cellular response to amino acid stimulus IMP
 biological_processGO:0071312 cellular response to alkaloid IDA
 biological_processGO:0071480 cellular response to gamma radiation IMP
 biological_processGO:0071839 apoptotic process in bone marrow IMP
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria ISO
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IMP
 biological_processGO:0097284 hepatocyte apoptotic process IMP
 biological_processGO:1900118 negative regulation of execution phase of apoptosis IEA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:1903077 negative regulation of protein localization to plasma membrane IEA
 biological_processGO:2000811 negative regulation of anoikis ISO
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0097136 Bcl-2 family protein complex IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0051434 BH3 domain binding IEA


Pathways (from Reactome)
Pathway description
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
The NLRP1 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bmp7tm1.2Dgra/Bmp7tm1.2Dgra
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cJ * C57BL/6J * C57BL/6NTac

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Aestm1Grid/Aestm1Grid,Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000727 absent CD4-8+ cells "lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+,Mcl1tm1Ywh/Mcl1tm1Ywh
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Bcl2l1tm1Dlo/Bcl2l1tm1Dlo,Casp9tm1Flv/Casp9tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Pdpk1tm1Bcol/Pdpk1tm1Bcol
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
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Allelic Composition: Arnttm1Gonz/Arnttm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Arnttm1Gonz/Arnttm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: 129P3/J-Leprdb-3J/J

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Arnttm1Gonz/Arnttm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Arnttm1Gonz/Arnttm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Arnttm1Gonz/Arnttm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arnttm1Gonz/Arnttm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: 129P3/J-Leprdb-3J/J

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: 129P3/J-Leprdb-3J/J

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Bmp7tm1.2Dgra/Bmp7tm1.2Dgra
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cJ * C57BL/6J * C57BL/6NTac

Allelic Composition: Bcl2l1Plt20/Bcl2l1Plt20
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Bcl2l1Plt20/Bcl2l1Plt16
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Bcl2l1Plt20/Bcl2l1+
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Bcl2l1tm1Dlo/Bcl2l1+
Genetic Background: B6.Cg-Bcl2l1tm1Dlo

Allelic Composition: Bcl2l1tm1Dlo/Bcl2l1Plt20
Genetic Background: involves: BALB/c * C57BL/6

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Bcl2l1tm1Dlo/Bcl2l1tm1Dlo,Casp9tm1Flv/?
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Baxtm1Dlo/Baxtm1Dlo,Bcl2l1tm1Dlo/Bcl2l1tm1Dlo
Genetic Background: involves: 129P2/OlaHsd

 MP:0003661 abnormal locus ceruleus "anomaly in a dense cluster of neurons within the dorsorostral pons; it is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic" [J:96328, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: 129P3/J-Leprdb-3J/J

 MP:0003790 absent CD4+8- cells "lack of the set of single-positive T cells that express CD4 on their surface" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0004720 abnormal platelet morphology "any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Bcl2l1tm1Dlo/Bcl2l1+
Genetic Background: B6.Cg-Bcl2l1tm1Dlo

Allelic Composition: Bak1tm1Thsn/Bak1+,Bcl2l1Plt20/Bcl2l1+
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Aestm1Grid/Aestm1Grid,Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bmp7tm1.2Dgra/Bmp7tm1.2Dgra
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cJ * C57BL/6J * C57BL/6NTac

Allelic Composition: Bcl2l1Plt20/Bcl2l1Plt20
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Bcl2l1Plt20/Bcl2l1+
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Bcl2l1tm1Dlo/Bcl2l1+
Genetic Background: B6.Cg-Bcl2l1tm1Dlo

Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Bcl2l1tm1Dlo/Bcl2l1+
Genetic Background: B6.Cg-Bcl2l1tm1Dlo Bak1tm1Thsn

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Bcl2l1tm1Dlo/Bcl2l1+
Genetic Background: B6.Cg-Bcl2l1tm1Dlo Bak1tm1Thsn

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
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Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: 129P3/J-Leprdb-3J/J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Bcl2l1tm1Dlo/Bcl2l1tm1Dlo,Casp9tm1Flv/Casp9tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Bcl2l1tm1Dlo/Bcl2l1tm1Dlo,Casp9tm1Flv/?
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l1tm1Dlo/Bcl2l1tm1Dlo,Casp9tm1Flv/Casp9tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008050 decreased memory T cell number "reduced number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008051 abnormal memory T cell physiology "any functional anomaly of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Bmp7tm1.2Dgra/Bmp7tm1.2Dgra
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cJ * C57BL/6J * C57BL/6NTac

Allelic Composition: Bcl2l1Plt20/Bcl2l1Plt20
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Bcl2l1Plt20/Bcl2l1+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arnttm1Gonz/Arnttm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008410 increased cellular sensitivity to ultraviolet irradiation "greater incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pon1tm1Lus/Pon1tm1Lus
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009153 pancreas tumor "tumors or cancer of the pancreas" [MESH:C04.588.274.761]
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Allelic Composition: Hcsttm1.1Cln/Hcsttm1.1Cln,Tyrobptm1Lll/Tyrobptm1Lll
Genetic Background: B6.Cg-Hcsttm1.1Cln Tyrobptm1Lll

Allelic Composition: Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam,Tg(RIP1-Tag)2Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0009580 increased keratinocyte apoptosis "increase in the number of keratinocytes undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pon1tm1Lus/Pon1tm1Lus
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Baxtm1Dlo/Baxtm1Dlo,Bcl2l1tm1Dlo/Bcl2l1tm1Dlo
Genetic Background: involves: 129P2/OlaHsd

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Bmp7tm1.2Dgra/Bmp7tm1.2Dgra
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cJ * C57BL/6J * C57BL/6NTac

 MP:0020543 decreased substantia nigra size "decreased size of the substantia nigra" [MGI:smb]
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Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: 129P3/J-Leprdb-3J/J

 MP:0030578 decreased keratinocyte adhesion "decreased ability of a keratinocyte to adhere to another cell or to a non-cellular component of the environment" [MGI:anna]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pon1tm1Lus/Pon1tm1Lus
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004446 Bid / P70444 / BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11 / P55957* / BH...  / complex / reaction
 ENSMUSG00000027381 O54918 / Bcl2l11 / Bcl-2-like protein 11 / O43521* / BCL2 like 11*  / reaction / complex
 ENSMUSG00000024521 Pmaip1 / Q9JM54 / phorbol-12-myristate-13-acetate-induced protein 1 / Q13794*  / complex / reaction
 ENSMUSG00000024959 Bad / Q61337 / Bcl2-associated agonist of cell death / Q92934*  / reaction / complex
 ENSMUSG00000069830 Nlrp1a / Q2LKU9 / NACHT, LRR and PYD domains-containing protein 1a / NLRP1* / Q9C000* / NLR family pyrin domain containing 1*  / reaction / complex
 ENSMUSG00000070390 A1Z198 / Nlrp1b / NACHT, LRR and PYD domains-containing protein 1b allele 2 / NLRP1* / Q9C000* / NLR family pyrin domain containing 1*  / reaction / complex






 

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