ENSDARG00000008434


Danio rerio

Features
Gene ID: ENSDARG00000008434
  
Biological name :bcl2l1
  
Synonyms : bcl2l1 / bcl2-like 1
  
Possible biological names infered from orthology : Mus musculus BCL2-like 1 (Bcl2l1), transcript variant 5, mRNA. / Q07817 / Q64373
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 18953870
Gene end: 18982499
  
Corresponding Affymetrix probe sets: Dr.11508.2.S1_a_at (Zebrafish Array)   Dr.11508.4.S1_a_at (Zebrafish Array)   NM_131807_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000027919
Ensembl peptide - ENSDARP00000119990
NCBI entrez gene - 114401     See in Manteia.
RefSeq - NM_131807
RefSeq Peptide - NP_571882
swissprot - Q90Z98
ZFIN ID - ZDB-GENE-010730-1
Ensembl - ENSDARG00000008434
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BCL2L1ENSGALG00000006211Gallus gallus
 BCL2L1ENSG00000171552Homo sapiens
 Bcl2l1ENSMUSG00000007659Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
bcl2a / BCL2, apoptosis regulator a / BCL2* / P10417* / P10415* / BCL2, apoptosis regulator* / Apoptosis regulator Bcl-2 *ENSDARG0000009470431
bcl2b / BCL2, apoptosis regulator b / BCL2* / P10417* / P10415* / BCL2, apoptosis regulator* / Apoptosis regulator Bcl-2 *ENSDARG0000008910928


Protein motifs (from Interpro)
Interpro ID Name
 IPR002475  Bcl2-like
 IPR003093  Apoptosis regulator, Bcl-2 protein, BH4
 IPR013279  Apoptosis regulator, Bcl-X
 IPR020717  Apoptosis regulator, Bcl-2, BH1 motif, conserved site
 IPR026298  Blc2 family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001894 tissue homeostasis IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA
 biological_processGO:0030878 thyroid gland development IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IBA
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
 molecular_functionGO:0046982 protein heterodimerization activity IBA


Pathways (from Reactome)
Pathway description
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
The NLRP1 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000012 central nervous system central nervous system hypoplastic , abnormal
Show

 ZFA:0001072 thyroid follicle thyroid follicle hypoplastic , abnormal
Show

 ZFA:0001094 whole organism whole organism lacks all parts of type extension , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000054937 badb / BCL2 associated agonist of cell death b / BAD* / Q61337* / Q92934* / BCL2 associated agonist of cell death*  / reaction / complex
 ENSDARG00000087993 bada / BCL2 associated agonist of cell death a / BAD* / Q92934* / BCL2 associated agonist of cell death*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr