ENSGALG00000006211


Gallus gallus

Features
Gene ID: ENSGALG00000006211
  
Biological name :BCL2L1
  
Synonyms : BCL2L1 / Bcl-2-like protein 1 / Q07816
  
Possible biological names infered from orthology : BCL2 like 1 / Mus musculus BCL2-like 1 (Bcl2l1), transcript variant 5, mRNA. / Q07817 / Q64373
  
Species: Gallus gallus
  
Chr. number: 20
Strand: -1
Band:
Gene start: 10217327
Gene end: 10234317
  
Corresponding Affymetrix probe sets: Gga.4944.1.S2_at (Chicken Array)   Gga.4944.2.A1_at (Chicken Array)   Gga.4944.2.S1_a_at (Chicken Array)   GgaAffx.21867.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000010012
Ensembl peptide - ENSGALP00000010059
Ensembl peptide - ENSGALP00000054103
NCBI entrez gene - 373954     See in Manteia.
RefSeq - XM_015296320
RefSeq - NM_001025304
RefSeq - XM_015296318
RefSeq - XM_015296319
RefSeq - XM_015296317
RefSeq Peptide - NP_001020475
swissprot - Q07816
Ensembl - ENSGALG00000006211
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bcl2l1ENSDARG00000008434Danio rerio
 BCL2L1ENSG00000171552Homo sapiens
 Bcl2l1ENSMUSG00000007659Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BCL2 / Q00709 / Apoptosis regulator Bcl-2 / P10415* / P10417* / BCL2, apoptosis regulator*ENSGALG0000001288543
BAK1 / BCL2 antagonist/killer 1 / O08734* / Q16611* / Bcl-2 homologous antagonist/killer *ENSGALG0000003149316


Protein motifs (from Interpro)
Interpro ID Name
 IPR002475  Bcl2-like
 IPR003093  Apoptosis regulator, Bcl-2 protein, BH4
 IPR004725  Apoptosis regulator, Bcl-2/ BclX
 IPR013279  Apoptosis regulator, Bcl-X
 IPR020717  Apoptosis regulator, Bcl-2, BH1 motif, conserved site
 IPR020726  Apoptosis regulator, Bcl-2, BH2 motif, conserved site
 IPR020728  Apoptosis regulator, Bcl-2, BH3 motif, conserved site
 IPR020731  Apoptosis regulator, Bcl-2, BH4 motif, conserved site
 IPR026298  Blc2 family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001836 release of cytochrome c from mitochondria IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007093 mitotic cell cycle checkpoint ISS
 biological_processGO:0007281 germ cell development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0009566 fertilization IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0019050 suppression by virus of host apoptotic process IEA
 biological_processGO:0032465 regulation of cytokinesis ISS
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0040007 growth IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0046898 response to cycloheximide IEA
 biological_processGO:0046902 regulation of mitochondrial membrane permeability IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0051881 regulation of mitochondrial membrane potential IEA
 biological_processGO:0060154 cellular process regulating host cell cycle in response to virus IEA
 biological_processGO:0070584 mitochondrion morphogenesis IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 biological_processGO:0071312 cellular response to alkaloid IEA
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:0071839 apoptotic process in bone marrow IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IBA
 biological_processGO:0097284 hepatocyte apoptotic process IEA
 biological_processGO:1900118 negative regulation of execution phase of apoptosis IEA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:1903077 negative regulation of protein localization to plasma membrane IEA
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IBA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0097136 Bcl-2 family protein complex IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0046982 protein heterodimerization activity IBA
 molecular_functionGO:0051434 BH3 domain binding IEA


Pathways (from Reactome)
Pathway description
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000013039 BID / BH3 interacting domain death agonist / P55957* / P70444* / BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-i...  / complex / reaction






 

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