ENSGALG00000031493


Gallus gallus

Features
Gene ID: ENSGALG00000031493
  
Biological name :BAK1
  
Synonyms : BAK1 / BCL2 antagonist/killer 1
  
Possible biological names infered from orthology : Bcl-2 homologous antagonist/killer / O08734 / Q16611
  
Species: Gallus gallus
  
Chr. number: 26
Strand: 1
Band:
Gene start: 4677808
Gene end: 4730058
  
Corresponding Affymetrix probe sets: Gga.12955.1.S1_at (Chicken Array)   GgaAffx.25775.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000055311
NCBI entrez gene - 419912     See in Manteia.
RefSeq - NM_001030920
RefSeq Peptide - NP_001026091
swissprot - Q5F404
Ensembl - ENSGALG00000031493
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BAK1ENSG00000030110Homo sapiens
 Bak1ENSMUSG00000057789Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BCL2 / Q00709 / Apoptosis regulator Bcl-2 / P10415* / P10417* / BCL2, apoptosis regulator*ENSGALG0000001288518
Q07816 / BCL2L1 / Bcl-2-like protein 1 / Q64373* / Q07817* / BCL2 like 1* / Mus musculus BCL2-like 1 (Bcl2l1), transcript variant 5, mRNA.*ENSGALG0000000621117


Protein motifs (from Interpro)
Interpro ID Name
 IPR002475  Bcl2-like
 IPR020717  Apoptosis regulator, Bcl-2, BH1 motif, conserved site
 IPR020726  Apoptosis regulator, Bcl-2, BH2 motif, conserved site
 IPR026298  Blc2 family
 IPR026308  Apoptosis regulator BAK


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001776 leukocyte homeostasis IEA
 biological_processGO:0001782 B cell homeostasis IEA
 biological_processGO:0001783 B cell apoptotic process IEA
 biological_processGO:0001836 release of cytochrome c from mitochondria IEA
 biological_processGO:0001974 blood vessel remodeling IEA
 biological_processGO:0002262 myeloid cell homeostasis IEA
 biological_processGO:0002352 B cell negative selection IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0008053 mitochondrial fusion IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c IEA
 biological_processGO:0009620 response to fungus IEA
 biological_processGO:0010046 response to mycotoxin IEA
 biological_processGO:0010248 establishment or maintenance of transmembrane electrochemical gradient IEA
 biological_processGO:0010332 response to gamma radiation IEA
 biological_processGO:0010524 positive regulation of calcium ion transport into cytosol IEA
 biological_processGO:0019835 cytolysis IEA
 biological_processGO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration IEA
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0035108 limb morphogenesis IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043496 regulation of protein homodimerization activity IEA
 biological_processGO:0043497 regulation of protein heterodimerization activity IEA
 biological_processGO:0044346 fibroblast apoptotic process IEA
 biological_processGO:0045862 positive regulation of proteolysis IEA
 biological_processGO:0046902 regulation of mitochondrial membrane permeability IEA
 biological_processGO:0048597 post-embryonic camera-type eye morphogenesis IEA
 biological_processGO:0048872 homeostasis of number of cells IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0051881 regulation of mitochondrial membrane potential IEA
 biological_processGO:0060068 vagina development IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
 biological_processGO:0070242 thymocyte apoptotic process IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0097190 apoptotic signaling pathway IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IEA
 biological_processGO:0097202 activation of cysteine-type endopeptidase activity IEA
 biological_processGO:1900103 positive regulation of endoplasmic reticulum unfolded protein response IEA
 biological_processGO:1902262 apoptotic process involved in blood vessel morphogenesis IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031307 integral component of mitochondrial outer membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0046930 pore complex IEA
 cellular_componentGO:0097145 BAK complex IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Activation and oligomerization of BAK protein
Release of apoptotic factors from the mitochondria


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000013039 BID / BH3 interacting domain death agonist / P55957* / P70444* / BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-i...  / complex / reaction
 ENSGALG00000031493 BAK1 / BCL2 antagonist/killer 1 / O08734* / Q16611* / Bcl-2 homologous antagonist/killer *  / reaction / complex






 

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