ENSMUSG00000057789


Mus musculus

Features
Gene ID: ENSMUSG00000057789
  
Biological name :Bak1
  
Synonyms : Bak1 / Bcl-2 homologous antagonist/killer / O08734
  
Possible biological names infered from orthology : BCL2 antagonist/killer 1 / Q16611
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 27019810
Gene end: 27029009
  
Corresponding Affymetrix probe sets: 10449303 (MoGene1.0st)   1418991_at (Mouse Genome 430 2.0 Array)   1425716_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025034
Ensembl peptide - ENSMUSP00000077757
Ensembl peptide - ENSMUSP00000122521
NCBI entrez gene - 12018     See in Manteia.
MGI - MGI:1097161
RefSeq - NM_007523
RefSeq Peptide - NP_031549
swissprot - F7CUQ1
swissprot - O08734
swissprot - Q91WX5
Ensembl - ENSMUSG00000057789
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BAK1ENSGALG00000031493Gallus gallus
 BAK1ENSG00000030110Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bcl2l1 / Q64373 / Mus musculus BCL2-like 1 (Bcl2l1), transcript variant 5, mRNA. / Q07817* / BCL2 like 1*ENSMUSG0000000765919
Bcl2l2 / P70345 / Bcl-2-like protein 2 / Q92843* / BCL2 like 2*ENSMUSG0000008968218
Bcl2 / P10417 / Apoptosis regulator Bcl-2 / P10415* / BCL2, apoptosis regulator*ENSMUSG0000005732917


Protein motifs (from Interpro)
Interpro ID Name
 IPR002475  Bcl2-like
 IPR020717  Apoptosis regulator, Bcl-2, BH1 motif, conserved site
 IPR020726  Apoptosis regulator, Bcl-2, BH2 motif, conserved site
 IPR020728  Apoptosis regulator, Bcl-2, BH3 motif, conserved site
 IPR026298  Blc2 family
 IPR026308  Apoptosis regulator BAK
 IPR036834  Blc2-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001776 leukocyte homeostasis IGI
 biological_processGO:0001782 B cell homeostasis IMP
 biological_processGO:0001783 B cell apoptotic process IGI
 biological_processGO:0001836 release of cytochrome c from mitochondria IMP
 biological_processGO:0001974 blood vessel remodeling IGI
 biological_processGO:0002262 myeloid cell homeostasis IGI
 biological_processGO:0002352 B cell negative selection IGI
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008053 mitochondrial fusion IGI
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c IMP
 biological_processGO:0009620 response to fungus IMP
 biological_processGO:0010046 response to mycotoxin IMP
 biological_processGO:0010225 response to UV-C IEA
 biological_processGO:0010248 establishment or maintenance of transmembrane electrochemical gradient IEA
 biological_processGO:0010332 response to gamma radiation IMP
 biological_processGO:0010524 positive regulation of calcium ion transport into cytosol IGI
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0019835 cytolysis IEA
 biological_processGO:0031018 endocrine pancreas development IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration IGI
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation IGI
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0035108 limb morphogenesis IGI
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043496 regulation of protein homodimerization activity IEA
 biological_processGO:0043497 regulation of protein heterodimerization activity IEA
 biological_processGO:0044346 fibroblast apoptotic process IMP
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045862 positive regulation of proteolysis IEA
 biological_processGO:0046902 regulation of mitochondrial membrane permeability IEA
 biological_processGO:0048597 post-embryonic camera-type eye morphogenesis IGI
 biological_processGO:0048872 homeostasis of number of cells IGI
 biological_processGO:0051726 regulation of cell cycle IGI
 biological_processGO:0051881 regulation of mitochondrial membrane potential IEA
 biological_processGO:0060068 vagina development IGI
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IGI
 biological_processGO:0070242 thymocyte apoptotic process IGI
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:0097190 apoptotic signaling pathway IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IGI
 biological_processGO:0097202 activation of cysteine-type endopeptidase activity IEA
 biological_processGO:1900103 positive regulation of endoplasmic reticulum unfolded protein response IEA
 biological_processGO:1902262 apoptotic process involved in blood vessel morphogenesis IGI
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005739 mitochondrion ISS
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031307 integral component of mitochondrial outer membrane IDA
 cellular_componentGO:0031966 mitochondrial membrane IDA
 cellular_componentGO:0046930 pore complex IEA
 cellular_componentGO:0097145 BAK complex IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051087 chaperone binding IEA
 molecular_functionGO:0051400 BH domain binding IEA


Pathways (from Reactome)
Pathway description
Activation and oligomerization of BAK protein
Release of apoptotic factors from the mitochondria


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000571 interdigital webbing "fold of skin, or web, between the toes that is not normally present" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0001144 fused vaginal opening "condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0001963 abnormal hearing "anomaly in the ability to receive auditory stimuli" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l11tm1Sjk/Bcl2l11tm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Hax1tm1Jni/Hax1tm1Jni,Bak1tm1Thsn/Bak1tm1Thsn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l11tm1Sjk/Bcl2l11tm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Srftm1Rjs/Srftm2.1Nor,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002993 arthritis "joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0003207 decreased sensitivity to gamma-irradiation "decreased incidence of cell death following high levels of gamma-irradiation" [J:92917, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0004720 abnormal platelet morphology "any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Bcl2l1tm1Dlo/Bcl2l1+
Genetic Background: B6.Cg-Bcl2l1tm1Dlo

Allelic Composition: Bak1tm1Thsn/Bak1+,Bcl2l1Plt20/Bcl2l1+
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005238 increased brain size "larger than the normal physical proportions of the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57958]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0005350 increased susceptibility to autoimmune disorders "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bcl2l1tm1Dlo/Bcl2l1+
Genetic Background: B6.Cg-Bcl2l1tm1Dlo

Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Bcl2l1tm1Dlo/Bcl2l1+
Genetic Background: B6.Cg-Bcl2l1tm1Dlo Bak1tm1Thsn

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l1tm1Dlo/Bcl2l1+
Genetic Background: B6.Cg-Bcl2l1tm1Dlo

Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Bcl2l1tm1Dlo/Bcl2l1+
Genetic Background: B6.Cg-Bcl2l1tm1Dlo Bak1tm1Thsn

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008206 increased B-2 cell number "greater number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0008947 increased neuron number "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0009308 adenocarcinoma "malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009333 abnormal splenocyte physiology "any functional anomaly of a cell of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0009542 decreased thymocyte apoptosis "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vdac2tm1.1Ehyc/Vdac2tm1.1Ehyc,Baxtm2Sjk/Baxtm2Sjk,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004446 Bid / P70444 / BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11 / P55957* / BH...  / complex / reaction
 ENSMUSG00000057789 Bak1 / O08734 / Bcl-2 homologous antagonist/killer / Q16611* / BCL2 antagonist/killer 1*  / complex / reaction






 

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