ENSG00000030110


Homo sapiens

Features
Gene ID: ENSG00000030110
  
Biological name :BAK1
  
Synonyms : BAK1 / BCL2 antagonist/killer 1 / Q16611
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.31
Gene start: 33572547
Gene end: 33580293
  
Corresponding Affymetrix probe sets: 203728_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000353878
Ensembl peptide - ENSP00000391258
Ensembl peptide - ENSP00000363591
NCBI entrez gene - 578     See in Manteia.
OMIM - 600516
RefSeq - XM_011514779
RefSeq - XM_011514780
RefSeq - NM_001188
RefSeq Peptide - NP_001179
swissprot - Q16611
swissprot - A0A0S2Z391
swissprot - A0A0A0MRG8
Ensembl - ENSG00000030110
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BAK1ENSGALG00000031493Gallus gallus
 Bak1ENSMUSG00000057789Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BCL2 / P10415 / BCL2, apoptosis regulatorENSG0000017179120
BCL2L2 / Q92843 / BCL2 like 2ENSG0000012947319
BCL2L1 / Q07817 / BCL2 like 1ENSG0000017155217


Protein motifs (from Interpro)
Interpro ID Name
 IPR002475  Bcl2-like
 IPR020717  Apoptosis regulator, Bcl-2, BH1 motif, conserved site
 IPR020726  Apoptosis regulator, Bcl-2, BH2 motif, conserved site
 IPR020728  Apoptosis regulator, Bcl-2, BH3 motif, conserved site
 IPR026298  Blc2 family
 IPR026308  Apoptosis regulator BAK
 IPR036834  Blc2-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001776 leukocyte homeostasis IEA
 biological_processGO:0001782 B cell homeostasis IEA
 biological_processGO:0001783 B cell apoptotic process IEA
 biological_processGO:0001836 release of cytochrome c from mitochondria IGI
 biological_processGO:0001974 blood vessel remodeling IEA
 biological_processGO:0002262 myeloid cell homeostasis IEA
 biological_processGO:0002352 B cell negative selection IEA
 biological_processGO:0006915 apoptotic process NAS
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0006987 obsolete activation of signaling protein activity involved in unfolded protein response TAS
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008053 mitochondrial fusion IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA
 biological_processGO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c IEA
 biological_processGO:0009620 response to fungus IEA
 biological_processGO:0010046 response to mycotoxin IEA
 biological_processGO:0010225 response to UV-C IEA
 biological_processGO:0010248 establishment or maintenance of transmembrane electrochemical gradient IDA
 biological_processGO:0010332 response to gamma radiation IEA
 biological_processGO:0010524 positive regulation of calcium ion transport into cytosol IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0019835 cytolysis IMP
 biological_processGO:0031018 endocrine pancreas development IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0032469 endoplasmic reticulum calcium ion homeostasis TAS
 biological_processGO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration IEA
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034644 cellular response to UV ISS
 biological_processGO:0035108 limb morphogenesis IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043496 regulation of protein homodimerization activity IDA
 biological_processGO:0043497 regulation of protein heterodimerization activity IDA
 biological_processGO:0044346 fibroblast apoptotic process IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045862 positive regulation of proteolysis IDA
 biological_processGO:0046902 regulation of mitochondrial membrane permeability IDA
 biological_processGO:0048597 post-embryonic camera-type eye morphogenesis IEA
 biological_processGO:0048872 homeostasis of number of cells IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0051881 regulation of mitochondrial membrane potential IDA
 biological_processGO:0060068 vagina development IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress TAS
 biological_processGO:0070242 thymocyte apoptotic process IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:0097190 apoptotic signaling pathway IMP
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IBA
 biological_processGO:0097202 activation of cysteine-type endopeptidase activity IDA
 biological_processGO:1900103 positive regulation of endoplasmic reticulum unfolded protein response IMP
 biological_processGO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway TAS
 biological_processGO:1902262 apoptotic process involved in blood vessel morphogenesis IEA
 biological_processGO:1903896 positive regulation of IRE1-mediated unfolded protein response TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031307 integral component of mitochondrial outer membrane ISS
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0046930 pore complex IDA
 cellular_componentGO:0097145 BAK complex IDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0044325 ion channel binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0051087 chaperone binding IEA
 molecular_functionGO:0051400 BH domain binding IEA


Pathways (from Reactome)
Pathway description
Activation and oligomerization of BAK protein
Release of apoptotic factors from the mitochondria


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000015475 BID / P55957 / BH3 interacting domain death agonist  / complex / reaction
 ENSG00000030110 BAK1 / Q16611 / BCL2 antagonist/killer 1  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr