ENSG00000015475


Homo sapiens

Features
Gene ID: ENSG00000015475
  
Biological name :BID
  
Synonyms : BH3 interacting domain death agonist / BID / P55957
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q11.21
Gene start: 17734138
Gene end: 17774770
  
Corresponding Affymetrix probe sets: 204493_at (Human Genome U133 Plus 2.0 Array)   211725_s_at (Human Genome U133 Plus 2.0 Array)   227143_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000480414
Ensembl peptide - ENSP00000477773
Ensembl peptide - ENSP00000481991
Ensembl peptide - ENSP00000483709
Ensembl peptide - ENSP00000483534
Ensembl peptide - ENSP00000318822
Ensembl peptide - ENSP00000344594
Ensembl peptide - ENSP00000382667
Ensembl peptide - ENSP00000382669
Ensembl peptide - ENSP00000382674
Ensembl peptide - ENSP00000449236
NCBI entrez gene - 637     See in Manteia.
OMIM - 601997
RefSeq - XM_017028906
RefSeq - NM_001196
RefSeq - NM_001244567
RefSeq - NM_001244569
RefSeq - NM_001244570
RefSeq - NM_001244572
RefSeq - NM_197966
RefSeq - NM_197967
RefSeq Peptide - NP_001231499
RefSeq Peptide - NP_001231501
RefSeq Peptide - NP_932070
RefSeq Peptide - NP_932071
RefSeq Peptide - NP_001187
RefSeq Peptide - NP_001231496
RefSeq Peptide - NP_001231498
swissprot - B2ZP78
swissprot - A8ASI8
swissprot - B2ZP79
swissprot - P55957
Ensembl - ENSG00000015475
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BIDENSGALG00000013039Gallus gallus
 BidENSMUSG00000004446Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR010479  BH3-interacting domain death agonist
 IPR020728  Apoptosis regulator, Bcl-2, BH3 motif, conserved site
 IPR036834  Blc2-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001836 release of cytochrome c from mitochondria IDA
 biological_processGO:0006626 protein targeting to mitochondrion IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors TAS
 biological_processGO:0008637 apoptotic mitochondrial changes TAS
 biological_processGO:0010918 positive regulation of mitochondrial membrane potential IEA
 biological_processGO:0032459 regulation of protein oligomerization IEA
 biological_processGO:0032461 positive regulation of protein oligomerization IDA
 biological_processGO:0032464 positive regulation of protein homooligomerization IDA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042770 signal transduction in response to DNA damage TAS
 biological_processGO:0042775 mitochondrial ATP synthesis coupled electron transport IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051402 neuron apoptotic process TAS
 biological_processGO:0090150 establishment of protein localization to membrane IDA
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IMP
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:0097284 hepatocyte apoptotic process IEA
 biological_processGO:0097345 mitochondrial outer membrane permeabilization IEA
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 biological_processGO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway TAS
 biological_processGO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process IEA
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:2000045 regulation of G1/S transition of mitotic cell cycle IEA
 biological_processGO:2000271 positive regulation of fibroblast apoptotic process IEA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IEA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IMP
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005741 mitochondrial outer membrane TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0032592 integral component of mitochondrial membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005123 death receptor binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Activation of BAD and translocation to mitochondria
Activation and oligomerization of BAK protein
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Activation, translocation and oligomerization of BAX
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Activation, myristolyation of BID and translocation to mitochondria


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100453 GZMB / P10144 / granzyme B  / reaction
 ENSG00000064012 CASP8 / Q14790 / caspase 8  / reaction
 ENSG00000136448 NMT1 / P30419 / N-myristoyltransferase 1  / reaction
 ENSG00000002330 BAD / Q92934 / BCL2 associated agonist of cell death  / reaction
 ENSG00000087088 BAX / Q07812 / BCL2 associated X, apoptosis regulator  / reaction / complex
 ENSG00000171791 BCL2 / P10415 / BCL2, apoptosis regulator  / reaction / complex
 ENSG00000030110 BAK1 / Q16611 / BCL2 antagonist/killer 1  / complex / reaction






 

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