ENSMUSG00000004446


Mus musculus

Features
Gene ID: ENSMUSG00000004446
  
Biological name :Bid
  
Synonyms : BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11 / Bid / P70444
  
Possible biological names infered from orthology : BH3 interacting domain death agonist / P55957
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F1
Gene start: 120891930
Gene end: 120916853
  
Corresponding Affymetrix probe sets: 10547531 (MoGene1.0st)   1417045_at (Mouse Genome 430 2.0 Array)   1447873_x_at (Mouse Genome 430 2.0 Array)   1448560_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004560
Ensembl peptide - ENSMUSP00000117529
Ensembl peptide - ENSMUSP00000125731
NCBI entrez gene - 12122     See in Manteia.
MGI - MGI:108093
RefSeq - XM_006505411
RefSeq - NM_007544
RefSeq - XM_006505409
RefSeq - XM_006505410
RefSeq Peptide - NP_031570
swissprot - D3Z463
swissprot - P70444
Ensembl - ENSMUSG00000004446
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BIDENSGALG00000013039Gallus gallus
 BIDENSG00000015475Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR010479  BH3-interacting domain death agonist
 IPR020728  Apoptosis regulator, Bcl-2, BH3 motif, conserved site
 IPR036834  Blc2-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001836 release of cytochrome c from mitochondria IEA
 biological_processGO:0006626 protein targeting to mitochondrion IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008637 apoptotic mitochondrial changes IDA
 biological_processGO:0010918 positive regulation of mitochondrial membrane potential IMP
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032459 regulation of protein oligomerization IDA
 biological_processGO:0032461 positive regulation of protein oligomerization IEA
 biological_processGO:0032464 positive regulation of protein homooligomerization IEA
 biological_processGO:0034349 glial cell apoptotic process IEA
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042770 signal transduction in response to DNA damage TAS
 biological_processGO:0042775 mitochondrial ATP synthesis coupled electron transport IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0090150 establishment of protein localization to membrane IEA
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IMP
 biological_processGO:0097284 hepatocyte apoptotic process IGI
 biological_processGO:0097345 mitochondrial outer membrane permeabilization IGI
 biological_processGO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process IGI
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:2000045 regulation of G1/S transition of mitotic cell cycle IMP
 biological_processGO:2000271 positive regulation of fibroblast apoptotic process IDA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IDA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0032592 integral component of mitochondrial membrane IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Activation of BAD and translocation to mitochondria
Activation and oligomerization of BAK protein
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Activation, translocation and oligomerization of BAX
Activation, myristolyation of BID and translocation to mitochondria


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000243 myoclonus "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bidtm1Sjk/Bidtm1Sjk,Cstbtm1Rm/Cstbtm1Rm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Cstbtm1Rm/Cstbtm1Rm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Bidtm1Sjk/Bidtm1Sjk
Genetic Background: involves: 129X1/Sv * C57BL/6

 MP:0001046 abnormal enteric neuron morphology "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Gdnftm1Rosl/Gdnf+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/1LacJ

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bidtm1Sjk/Bidtm1Sjk
Genetic Background: involves: 129X1/Sv * C57BL/6

 MP:0001316 corneal scarring "appearance of fibrous tissue on the cornea after healing in response to injury " [J:30249]
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Allelic Composition: Bidtm1Sjk/Bidtm1Sjk,Cstbtm1Rm/Cstbtm1Rm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Bidtm1Sjk/Bidtm1Sjk,Cstbtm1Rm/Cstbtm1Rm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bidtm1Sjk/Bidtm1Sjk
Genetic Background: involves: 129X1/Sv * C57BL/6

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bidtm1Sjk/Bidtm1Sjk
Genetic Background: involves: 129X1/Sv * C57BL/6

 MP:0002273 abnormal alveolar epithelial cell morphology "any structural anomaly of the cells lining the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bidtm1Sjk/Bidtm1Sjk
Genetic Background: involves: 129X1/Sv * C57BL/6

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cstbtm1Rm/Cstbtm1Rm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003992 increased mortality induced by ionizing radiation "greater sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

 MP:0004098 abnormal granule neuron "any structural anomaly of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Bidtm1Sjk/Bidtm1Sjk,Cstbtm1Rm/Cstbtm1Rm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bidtm1Sjk/Bidtm1Sjk,Cstbtm1Rm/Cstbtm1Rm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

Allelic Composition: Bidtm1.1Ast/Bidtm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6 * NZB

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/1LacJ

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo5argsc229/Myo5argsc229
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

Allelic Composition: Bidtm1Sjk/Bidtm1Sjk
Genetic Background: involves: 129X1/Sv * C57BL/6

Allelic Composition: Bidtm1.1Ast/Bidtm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6 * NZB

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Bidtm1Sjk/Bidtm1Sjk,Relatm1Bal/Relatm1Bal
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0013502 decreased fibroblast apoptosis "reduction in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Bidtm1Sjk/Bidtm1Sjk,Relatm1Bal/Relatm1Bal
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000057329 Bcl2 / P10417 / Apoptosis regulator Bcl-2 / P10415* / BCL2, apoptosis regulator*  / complex / reaction
 ENSMUSG00000003873 Bax / Q07813 / Apoptosis regulator BAX / Q07812* / BCL2 associated X, apoptosis regulator*  / reaction / complex
 ENSMUSG00000057789 Bak1 / O08734 / Bcl-2 homologous antagonist/killer / Q16611* / BCL2 antagonist/killer 1*  / complex / reaction
 ENSMUSG00000007659 Bcl2l1 / Q64373 / Mus musculus BCL2-like 1 (Bcl2l1), transcript variant 5, mRNA. / Q07817* / BCL2 like 1*  / reaction / complex
 ENSMUSG00000015437 Gzmb / P04187 / granzyme B / P10144*  / reaction
 ENSMUSG00000079186 Gzmc / P08882 / Granzyme C / GZMB* / P10144* / granzyme B*  / reaction
 ENSMUSG00000026029 Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*  / reaction
 ENSMUSG00000020936 Nmt1 / O70310 / Glycylpeptide N-tetradecanoyltransferase 1 / P30419* / N-myristoyltransferase 1*  / reaction
 ENSMUSG00000024959 Bad / Q61337 / Bcl2-associated agonist of cell death / Q92934*  / reaction






 

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