ENSMUSG00000003873


Mus musculus

Features
Gene ID: ENSMUSG00000003873
  
Biological name :Bax
  
Synonyms : Apoptosis regulator BAX / Bax / Q07813
  
Possible biological names infered from orthology : BCL2 associated X, apoptosis regulator / Q07812
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 45461697
Gene end: 45466898
  
Corresponding Affymetrix probe sets: 10563303 (MoGene1.0st)   1416837_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033093
Ensembl peptide - ENSMUSP00000148265
Ensembl peptide - ENSMUSP00000148240
Ensembl peptide - ENSMUSP00000148182
Ensembl peptide - ENSMUSP00000147753
NCBI entrez gene - 12028     See in Manteia.
MGI - MGI:99702
RefSeq - XM_011250780
RefSeq - NM_007527
RefSeq - XM_006540584
RefSeq Peptide - NP_031553
swissprot - A0A1B0GTA4
swissprot - A0A1B0GT81
swissprot - Q544Z6
swissprot - A0A1B0GT35
swissprot - A0A1B0GS13
swissprot - Q07813
Ensembl - ENSMUSG00000003873
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 baxaENSDARG00000089129Danio rerio
 baxaENSDARG00000020623Danio rerio
 baxbENSDARG00000030881Danio rerio
 BX511080.1ENSDARG00000089995Danio rerio
 BAXENSG00000087088Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002475  Bcl2-like
 IPR020717  Apoptosis regulator, Bcl-2, BH1 motif, conserved site
 IPR020726  Apoptosis regulator, Bcl-2, BH2 motif, conserved site
 IPR020728  Apoptosis regulator, Bcl-2, BH3 motif, conserved site
 IPR026298  Blc2 family
 IPR026304  Apoptosis regulator BAX
 IPR036834  Blc2-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0001776 leukocyte homeostasis IGI
 biological_processGO:0001777 T cell homeostatic proliferation IMP
 biological_processGO:0001782 B cell homeostasis IMP
 biological_processGO:0001783 B cell apoptotic process IEA
 biological_processGO:0001822 kidney development IGI
 biological_processGO:0001836 release of cytochrome c from mitochondria IEA
 biological_processGO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway IMP
 biological_processGO:0001974 blood vessel remodeling IGI
 biological_processGO:0002262 myeloid cell homeostasis IGI
 biological_processGO:0002352 B cell negative selection IGI
 biological_processGO:0002358 B cell homeostatic proliferation IMP
 biological_processGO:0002904 positive regulation of B cell apoptotic process IGI
 biological_processGO:0006687 glycosphingolipid metabolic process IMP
 biological_processGO:0006808 regulation of nitrogen utilization IGI
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007281 germ cell development IGI
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0007548 sex differentiation IMP
 biological_processGO:0008053 mitochondrial fusion IEA
 biological_processGO:0008283 cell proliferation IGI
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IDA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c IEA
 biological_processGO:0008637 apoptotic mitochondrial changes IEA
 biological_processGO:0009566 fertilization IGI
 biological_processGO:0009611 response to wounding IMP
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0009651 response to salt stress IGI
 biological_processGO:0009791 post-embryonic development IGI
 biological_processGO:0010212 response to ionizing radiation IMP
 biological_processGO:0010248 establishment or maintenance of transmembrane electrochemical gradient IEA
 biological_processGO:0010332 response to gamma radiation IMP
 biological_processGO:0010524 positive regulation of calcium ion transport into cytosol IGI
 biological_processGO:0021854 hypothalamus development IMP
 biological_processGO:0021987 cerebral cortex development IMP
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032461 positive regulation of protein oligomerization IEA
 biological_processGO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration IGI
 biological_processGO:0032976 release of matrix enzymes from mitochondria IEA
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation IGI
 biological_processGO:0033599 regulation of mammary gland epithelial cell proliferation IMP
 biological_processGO:0034644 cellular response to UV IGI
 biological_processGO:0035108 limb morphogenesis IGI
 biological_processGO:0035234 ectopic germ cell programmed cell death IMP
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IGI
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0043496 regulation of protein homodimerization activity IEA
 biological_processGO:0043497 regulation of protein heterodimerization activity IEA
 biological_processGO:0043523 regulation of neuron apoptotic process IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IDA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0043653 mitochondrial fragmentation involved in apoptotic process IEA
 biological_processGO:0045136 development of secondary sexual characteristics IMP
 biological_processGO:0046666 retinal cell programmed cell death IMP
 biological_processGO:0048087 positive regulation of developmental pigmentation IGI
 biological_processGO:0048147 negative regulation of fibroblast proliferation IMP
 biological_processGO:0048515 spermatid differentiation IMP
 biological_processGO:0048597 post-embryonic camera-type eye morphogenesis IGI
 biological_processGO:0048678 response to axon injury IMP
 biological_processGO:0048872 homeostasis of number of cells IMP
 biological_processGO:0048873 homeostasis of number of cells within a tissue IMP
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IMP
 biological_processGO:0051402 neuron apoptotic process IMP
 biological_processGO:0051726 regulation of cell cycle IGI
 biological_processGO:0051881 regulation of mitochondrial membrane potential IEA
 biological_processGO:0060011 Sertoli cell proliferation IGI
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060058 positive regulation of apoptotic process involved in mammary gland involution IMP
 biological_processGO:0060068 vagina development IGI
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
 biological_processGO:0070242 thymocyte apoptotic process IGI
 biological_processGO:0070584 mitochondrion morphogenesis IGI
 biological_processGO:0071310 cellular response to organic substance IDA
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IMP
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:0097190 apoptotic signaling pathway IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IGI
 biological_processGO:0097193 intrinsic apoptotic signaling pathway IEA
 biological_processGO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
 biological_processGO:1900103 positive regulation of endoplasmic reticulum unfolded protein response IEA
 biological_processGO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process IGI
 biological_processGO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process IGI
 biological_processGO:1902262 apoptotic process involved in blood vessel morphogenesis IGI
 biological_processGO:1902263 apoptotic process involved in embryonic digit morphogenesis IGI
 biological_processGO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death IMP
 biological_processGO:1902512 positive regulation of apoptotic DNA fragmentation IEA
 biological_processGO:1990117 B cell receptor apoptotic signaling pathway IEA
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway IGI
 biological_processGO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane IDA
 cellular_componentGO:0005757 mitochondrial permeability transition pore complex IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IDA
 cellular_componentGO:0046930 pore complex IEA
 cellular_componentGO:0071944 cell periphery IEA
 cellular_componentGO:0097136 Bcl-2 family protein complex IEA
 cellular_componentGO:0097144 BAX complex IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0015267 channel activity IEA
 molecular_functionGO:0030544 Hsp70 protein binding IDA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051087 chaperone binding IPI
 molecular_functionGO:0051434 BH3 domain binding IEA


Pathways (from Reactome)
Pathway description
Release of apoptotic factors from the mitochondria
Activation, translocation and oligomerization of BAX
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000571 interdigital webbing "fold of skin, or web, between the toes that is not normally present" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Pkd2m1Btlr/Pkd2m1Btlr
Genetic Background: C57BL/6J-Pkd2m1Btlr

 MP:0000714 increased thymocyte number "greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Vdac2tm1.1Ehyc/Vdac2tm1.1Ehyc,Baxtm2Sjk/Baxtm2Sjk,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Pcdhgtm1.1Tman/Pcdhgtm1.1Tman
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Bax+,Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Bax+,Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Bax+,Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

 MP:0000909 abnormal facial motor nucleus morphology "malformation or disorganization of the group of motor neurons residing in the pons that innervate the muscles of facial expression" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Tg(SOD1*G93A)1Gur/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Tg(SOD1*G93A)1Gur/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Tg(SOD1*G93A)1Gur/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Mapttm2Arbr/Mapt+,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Ntf3tm1Jae/Ntf3tm1Jae
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Islr2tm1.1Ddg/Islr2tm1.1Ddg
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0001011 abnormal superior cervical ganglion morphology "malformation or absence of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0001025 abnormal sympathetic neuron morphology "malformation or anomalous development of any of the neurons of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Baxtm1Sjk/Bax+
Genetic Background: involves: 129X1/SvJ

 MP:0001046 abnormal enteric neuron morphology "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Gdnftm1Rosl/Gdnf+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Rettm1Heno/Rettm3.1(Bcl2l1)Heno,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0001078 abnormal phrenic nerve "malformed or misprojection of motor and sensory neuron axons to the diaphragm and other tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Col25a1tm1.1Tiwa/Col25a1+
Genetic Background: B6.Cg-Col25a1tm1.1Tiwa Baxtm1Sjk

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Smad5tm1Zuk/Smad5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001144 fused vaginal opening "condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2l11tm1.1Ast Baxtm1Sjk

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Smad5tm1Zuk/Smad5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: B6.129X1-Baxtm1Sjk/J

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2.1Bhr,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: B6.129-Baxtm1Sjk Lama2tm1Eeng

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: B6.129-Baxtm1Sjk Lama2tm1Eeng

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Pcdhgtm1.1Tman/Pcdhgtm1.1Tman
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Baxtm2Sjk/Baxtm2Sjk,Scyl2tm1.1Spel/Scyl2tm1.1Spel,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Bax+,Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

Allelic Composition: Cbln1tm1Jim/Cbln1tm1Jim,Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Pcdhgtm1.1Tman/Pcdhgtm1.1Tman
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Tg(SOD1*G93A)1Gur/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: B6.129-Baxtm1Sjk Lama2tm1Eeng

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Arnttm1Gonz/Arnttm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: B6.129X1-Baxtm1Sjk/J

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2l11tm1.1Ast Baxtm1Sjk

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
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Allelic Composition: Baxtm1Sjk/Bax+,Nanos2tm1Ysa/Nanos2tm1Ysa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001931 abnormal oogenesis "atypical formation or failure to form the female germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Wnt4tm1Amc/Wnt4tm3(EGFP/cre)Amc
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001963 abnormal hearing "anomaly in the ability to receive auditory stimuli" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l11tm1Sjk/Bcl2l11tm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Hax1tm1Jni/Hax1tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Tg(SOD1*G93A)1Gur/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: B6.129-Baxtm1Sjk Lama2tm1Eeng

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l11tm1Sjk/Bcl2l11tm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Tg(SOD1*G93A)1Gur/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smad5tm1Zuk/Smad5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: B6.129X1-Baxtm1Sjk/J

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Srftm1Rjs/Srftm2.1Nor,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Islr2tm1.1Ddg/Islr2tm1.1Ddg
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Ngftm1Gne/Ngftm1Gne
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Ntrk1tm1Apat/Ntrk1tm1Apat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002982 abnormal germ cell migration "defects in the orderly movement of a germ cell, a cell specialized to produce haploid gametes, from one site to another during development" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Sall4tm2.1Tre/Sall4tm2.1Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Ror2Y324C/Ror2Y324C
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002993 arthritis "joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: B6.129-Baxtm1Sjk Lama2tm1Eeng

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Baxtm1Dlo/Baxtm1Dlo
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Baxtm1Dlo/Baxtm1Dlo,Bcl2l1tm1Dlo/Bcl2l1tm1Dlo
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003207 decreased sensitivity to gamma-irradiation "decreased incidence of cell death following high levels of gamma-irradiation" [J:92917, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0003491 abnormal voluntary movement "anomalies in coordinated movements executed with a purpose and can be improved by learning and/or experience" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Pcdhgtm1.1Tman/Pcdhgtm1.1Tman
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0004297 abnormal proprioceptive neuron morphology "any structural anomaly in the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Ntrk1tm2(Ntrk3)Apat/Ntrk1tm2(Ntrk3)Apat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Ntf3tm1Jae/Ntf3tm1Jae
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Etv1tm2Tmj/Etv1tm2Tmj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004818 increased skeletal muscle mass "increase in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: B6.129-Baxtm1Sjk Lama2tm1Eeng

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: B6.129X1-Baxtm1Sjk/J

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Bax+,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: B6.129X1-Baxtm1Sjk/J

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2l11tm1.1Ast Baxtm1Sjk

Allelic Composition: Baxtm1Sjk/Bax+,Nanos2tm1Ysa/Nanos2tm1Ysa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Nanos2tm1Ysa/Nanos2tm1Ysa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005192 increased motor neuron number "greater than the normal number of cells that innervate an effector (muscle or glandular) tissue" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Baxtm1Sjk/Bax+
Genetic Background: involves: 129X1/SvJ

 MP:0005238 increased brain size "larger than the normal physical proportions of the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57958]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0005350 increased susceptibility to autoimmune disorders "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0006006 increased sensory neuron number "greater than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Etv1tm2Tmj/Etv1tm2Tmj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Tg(SOD1*G93A)1Gur/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l1tm1Dlo/Bcl2l1tm1Dlo,Casp9tm1Flv/?
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008206 increased B-2 cell number "greater number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: B6.129X1-Baxtm1Sjk/J

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2l11tm1.1Ast Baxtm1Sjk

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Baxtm1Sjk/Bax+,Nanos2tm1Ysa/Nanos2tm1Ysa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008390 abnormal primordial germ cell proliferation "anomaly in the ability of the primordial germ cell population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sall4tm2.1Tre/Sall4tm2.1Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: Baxtm1Sjk/Bax+,KitlSl/KitlSl,Tg(Pou5f1-GFP)1Scho/?
Genetic Background: involves: 129X1/SvJ * C3H * CD-1 * FVB

 MP:0008391 abnormal primordial germ cell morphology "any structural anomaly of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Ror2Y324C/Ror2Y324C
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Ror2Y324C/Ror2Y324C
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008468 absent muscle spindles "absence of the sensory organs in muscle that are involved in the stretch reflex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Ntf3tm1Jae/Ntf3tm1Jae
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0008485 increased muscle spindle number "greater number of the sensory organs in muscle that are involved in the stretch reflex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Ntrk1tm2(Ntrk3)Apat/Ntrk1tm2(Ntrk3)Apat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

 MP:0008870 increased mature ovarian follicle number "than normal numbers of spheroid cell aggregations in the ovary containing the ovum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0008924 decreased granule neuron number "reduction in the number of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Baxtm1Sjk/Bax+,Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

 MP:0008947 increased neuron number "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0009083 uterus hypertrophy "increase in the bulk size of the female muscular organ of gestation due to cell enlargement" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009308 adenocarcinoma "malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009333 abnormal splenocyte physiology "any functional anomaly of a cell of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0009542 decreased thymocyte apoptosis "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vdac2tm1.1Ehyc/Vdac2tm1.1Ehyc,Baxtm2Sjk/Baxtm2Sjk,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009719 reduced cerebellar foliation "the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Bax+,Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Pcdhgtm1.1Tman/Pcdhgtm1.1Tman
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Pcdhgtm1.1Tman/Pcdhgtm1.1Tman
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Baxtm1Dlo/Baxtm1Dlo,Bcl2l1tm1Dlo/Bcl2l1tm1Dlo
Genetic Background: involves: 129P2/OlaHsd

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Baxtm2Sjk/Baxtm2Sjk,Scyl2tm1.1Spel/Scyl2tm1.1Spel,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2l11tm1.1Ast Baxtm1Sjk

 MP:0012055 abnormal phrenic nerve innervation pattern to diaphragm "any changes in the placement, morphology or number of the portion of phrenic nerve fibers providing motor supply to the diaphragm" [MGI:csmith]
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Allelic Composition: Col25a1tm1.1Tiwa/Col25a1tm1.1Tiwa,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: B6.Cg-Col25a1tm1.1Tiwa Tg(Hlxb9-GFP)1Tmj

 MP:0013237 abnormal skeletal muscle regeneration "anomaly in the ability to repair skeletal muscle after injury or disease" [MGI:csmith]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: B6.129-Baxtm1Sjk Lama2tm1Eeng

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004446 Bid / P70444 / BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11 / P55957* / BH...  / complex / reaction
 ENSMUSG00000003873 Bax / Q07813 / Apoptosis regulator BAX / Q07812* / BCL2 associated X, apoptosis regulator*  / complex / reaction
 ENSMUSG00000047281 Sfn / O70456 / stratifin / P31947*  / complex / reaction






 

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