ENSMUSG00000020936


Mus musculus

Features
Gene ID: ENSMUSG00000020936
  
Biological name :Nmt1
  
Synonyms : Glycylpeptide N-tetradecanoyltransferase 1 / Nmt1 / O70310
  
Possible biological names infered from orthology : N-myristoyltransferase 1 / P30419
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E1
Gene start: 103028190
Gene end: 103068912
  
Corresponding Affymetrix probe sets: 10381668 (MoGene1.0st)   10338077 (MoGene1.0st)   10338764 (MoGene1.0st)   10338847 (MoGene1.0st)   10338853 (MoGene1.0st)   10339349 (MoGene1.0st)   10339674 (MoGene1.0st)   10340121 (MoGene1.0st)   10340609 (MoGene1.0st)   10340769 (MoGene1.0st)   10340843 (MoGene1.0st)   10341675 (MoGene1.0st)   10341875 (MoGene1.0st)   10341918 (MoGene1.0st)   10342577 (MoGene1.0st)   10342697 (MoGene1.0st)   10342912 (MoGene1.0st)   10344089 (MoGene1.0st)   10344607 (MoGene1.0st)   10338154 (MoGene1.0st)   10338715 (MoGene1.0st)   10339631 (MoGene1.0st)   10341049 (MoGene1.0st)   10341303 (MoGene1.0st)   10341365 (MoGene1.0st)   10342330 (MoGene1.0st)   10343270 (MoGene1.0st)   10344322 (MoGene1.0st)   10344489 (MoGene1.0st)   1415683_at (Mouse Genome 430 2.0 Array)   1418082_at (Mouse Genome 430 2.0 Array)   1454941_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021314
NCBI entrez gene - 18107     See in Manteia.
MGI - MGI:102579
RefSeq - XM_006532445
RefSeq - NM_008707
RefSeq Peptide - NP_032733
swissprot - O70310
swissprot - Q3UJC3
Ensembl - ENSMUSG00000020936
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nmt1aENSDARG00000052966Danio rerio
 NMT1ENSGALG00000000857Gallus gallus
 NMT1ENSG00000136448Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nmt2 / O70311 / Glycylpeptide N-tetradecanoyltransferase 2 / O60551* / N-myristoyltransferase 2*ENSMUSG0000002664372


Protein motifs (from Interpro)
Interpro ID Name
 IPR000903  Myristoyl-CoA:protein N-myristoyltransferase
 IPR016181  Acyl-CoA N-acyltransferase
 IPR022676  Myristoyl-CoA:protein N-myristoyltransferase, N-terminal
 IPR022677  Myristoyl-CoA:protein N-myristoyltransferase, C-terminal
 IPR022678  Myristoyl-CoA:protein N-myristoyltransferase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006499 N-terminal protein myristoylation IMP
 biological_processGO:0018008 N-terminal peptidyl-glycine N-myristoylation IEA
 biological_processGO:0042180 cellular ketone metabolic process IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane IEA
 molecular_functionGO:0004379 glycylpeptide N-tetradecanoyltransferase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0019107 myristoyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Inactivation, recovery and regulation of the phototransduction cascade
Activation, myristolyation of BID and translocation to mitochondria


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppargc1btm1.1Javi/Ppargc1btm1.1Javi,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Nmt1tm1.1Poru/Nmt1tm1.1Poru,Nmt2tm1.1Poru/Nmt2tm1.1Poru,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ppargc1btm1.1Javi/Ppargc1btm1.1Javi,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Nmt1tm1.1Poru/Nmt1tm1.1Poru,Nmt2tm1.1Poru/Nmt2tm1.1Poru,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppargc1btm1.1Javi/Ppargc1btm1.1Javi,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Nmt1tm1.1Poru/Nmt1tm1.1Poru,Nmt2tm1.1Poru/Nmt2tm1.1Poru,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nmt1tm1.1Poru/Nmt1tm1.1Poru,Nmt2tm1.1Poru/Nmt2tm1.1Poru,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ppargc1btm1.1Javi/Ppargc1btm1.1Javi,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Nmt1tm1.1Poru/Nmt1tm1.1Poru,Nmt2tm1.1Poru/Nmt2tm1.1Poru,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nmt1tm1.1Poru/Nmt1tm1.1Poru,Nmt2tm1.1Poru/Nmt2tm1.1Poru,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nmt1tm1.1Poru/Nmt1tm1.1Poru,Nmt2tm1.1Poru/Nmt2tm1.1Poru,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppargc1btm1.1Javi/Ppargc1btm1.1Javi,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Nmt1tm1.1Poru/Nmt1tm1.1Poru,Nmt2tm1.1Poru/Nmt2tm1.1Poru,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008346 increased gamma-delta T cell number "greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Nmt1tm1.1Poru/Nmt1tm1.1Poru,Nmt2tm1.1Poru/Nmt2tm1.1Poru,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Nmt1tm1.1Poru/Nmt1tm1.1Poru,Nmt2tm1.1Poru/Nmt2tm1.1Poru,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Nmt1tm1.1Poru/Nmt1tm1.1Poru,Nmt2tm1.1Poru/Nmt2tm1.1Poru,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Nmt1tm1.1Poru/Nmt1tm1.1Poru,Nmt2tm1.1Poru/Nmt2tm1.1Poru,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008600 decreased circulating interleukin-2 level "reduction in the amount in the blood of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Nmt1tm1.1Poru/Nmt1tm1.1Poru,Nmt2tm1.1Poru/Nmt2tm1.1Poru,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Nmt1tm1.1Poru/Nmt1tm1.1Poru,Nmt2tm1.1Poru/Nmt2tm1.1Poru,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nmt1tm1.1Poru/Nmt1tm1.1Poru,Nmt2tm1.1Poru/Nmt2tm1.1Poru,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0009335 decreased splenocyte proliferation "reduction in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nmt1tm1.1Poru/Nmt1tm1.1Poru,Nmt2tm1.1Poru/Nmt2tm1.1Poru,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0010136 decreased DN4 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [CL:0000808]
Show

Allelic Composition: Nmt1tm1.1Poru/Nmt1tm1.1Poru,Nmt2tm1.1Poru/Nmt2tm1.1Poru,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Ccne1tm1Jro/?,Krastm3Tyj/?
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ccne1tm1Jro/?,Krastm3Tyj/?
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0013588 small thymus medulla "decreased size of the inner area of thymus lobules" [MGI:Anna]
Show

Allelic Composition: Nmt1tm1.1Poru/Nmt1tm1.1Poru,Nmt2tm1.1Poru/Nmt2tm1.1Poru,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004446 Bid / P70444 / BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11 / P55957* / BH...  / reaction
 ENSMUSG00000034837 Gnat1 / P20612 / guanine nucleotide binding protein, alpha transducing 1 / P11488* / G protein subunit alpha transducin 1*  / reaction






 

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