ENSMUSG00000024959


Mus musculus

Features
Gene ID: ENSMUSG00000024959
  
Biological name :Bad
  
Synonyms : Bad / Bcl2-associated agonist of cell death / Q61337
  
Possible biological names infered from orthology : Q92934
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 6941861
Gene end: 6951898
  
Corresponding Affymetrix probe sets: 10461017 (MoGene1.0st)   1416582_a_at (Mouse Genome 430 2.0 Array)   1416583_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109053
Ensembl peptide - ENSMUSP00000114597
Ensembl peptide - ENSMUSP00000121778
Ensembl peptide - ENSMUSP00000109050
Ensembl peptide - ENSMUSP00000025910
NCBI entrez gene - 12015     See in Manteia.
MGI - MGI:1096330
RefSeq - NM_001285453
RefSeq - NM_007522
RefSeq Peptide - NP_001272382
RefSeq Peptide - NP_031548
swissprot - Q61337
swissprot - D3YZR8
swissprot - F6S493
swissprot - F7ABX5
swissprot - Q3U9H3
Ensembl - ENSMUSG00000024959
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 badaENSDARG00000087993Danio rerio
 badbENSDARG00000054937Danio rerio
 BADENSG00000002330Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR018868  Bcl2-associated agonist of cell death


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001836 release of cytochrome c from mitochondria IMP
 biological_processGO:0006007 glucose catabolic process IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IMP
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010918 positive regulation of mitochondrial membrane potential IMP
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0019050 suppression by virus of host apoptotic process IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0032024 positive regulation of insulin secretion IMP
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0033133 positive regulation of glucokinase activity IMP
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0034201 response to oleic acid IEA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0042981 regulation of apoptotic process IDA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0044342 type B pancreatic cell proliferation IMP
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045579 positive regulation of B cell differentiation IMP
 biological_processGO:0045582 positive regulation of T cell differentiation IMP
 biological_processGO:0045862 positive regulation of proteolysis IEA
 biological_processGO:0045918 negative regulation of cytolysis IEA
 biological_processGO:0046031 ADP metabolic process IMP
 biological_processGO:0046034 ATP metabolic process IMP
 biological_processGO:0046902 regulation of mitochondrial membrane permeability IEA
 biological_processGO:0046931 pore complex assembly IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0060139 positive regulation of apoptotic process by virus IDA
 biological_processGO:0060154 cellular process regulating host cell cycle in response to virus IDA
 biological_processGO:0071247 cellular response to chromate IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071310 cellular response to organic substance ISO
 biological_processGO:0071316 cellular response to nicotine IEA
 biological_processGO:0071396 cellular response to lipid IEP
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:0097190 apoptotic signaling pathway IMP
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IMP
 biological_processGO:0097193 intrinsic apoptotic signaling pathway IEA
 biological_processGO:0097202 activation of cysteine-type endopeptidase activity IEA
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1902220 positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress IDA
 biological_processGO:2000078 positive regulation of type B pancreatic cell development IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0030346 protein phosphatase 2B binding IEA
 molecular_functionGO:0043422 protein kinase B binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0071889 14-3-3 protein binding IEA


Pathways (from Reactome)
Pathway description
Activation of BAD and translocation to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
NRAGE signals death through JNK


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pecam1Gt(OST16303)Lex/Pecam1Gt(OST16303)Lex
Genetic Background: B6.129S-Pecam1Gt(OST16303)Lex/J

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nat2tm1Esim/Nat2tm1Esim
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Bidtm1Sjk/Bidtm1Sjk,Relatm1Bal/Relatm1Bal
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nat2tm1Esim/Nat2tm1Esim
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ktn1tm1.1Kpf/Ktn1tm1.1Kpf
Genetic Background: involves: 129P2/OlaHsd

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: Nat2tm1Esim/Nat2tm1Esim
Genetic Background: involves: 129P2/OlaHsd * A/J

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
Show

Allelic Composition: Nat2tm1Esim/Nat2tm1Esim
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Nat2tm1Esim/Nat2tm1Esim
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nat2tm1Esim/Nat2tm1Esim
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pecam1Gt(OST16303)Lex/Pecam1Gt(OST16303)Lex
Genetic Background: B6.129S-Pecam1Gt(OST16303)Lex/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nat2tm1Esim/Nat2tm1Esim
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nat2tm1Esim/Nat2tm1Esim
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bidtm1Sjk/Bidtm1Sjk,Relatm1Bal/Relatm1Bal
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nat2tm1Esim/Nat2tm1Esim
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nat2tm1Esim/Nat2tm1Esim
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Badtm1Sjk/Badtm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Badtm2Meg/Badtm2Meg
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Badtm1Sjk/Badtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Badtm1Sjk/Badtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

 MP:0009167 increased pancreatic islet number "increase in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Badtm1Sjk/Badtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Nat2tm1Esim/Nat2tm1Esim
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0014117 increased pancreatic beta cell apoptosis "increase in the number of pancreatic beta cells undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
Show

Allelic Composition: Nat2tm1Esim/Nat2tm1Esim
Genetic Background: involves: 129P2/OlaHsd * A/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007659 Bcl2l1 / Q64373 / Mus musculus BCL2-like 1 (Bcl2l1), transcript variant 5, mRNA. / Q07817* / BCL2 like 1*  / complex / reaction
 ENSMUSG00000027381 O54918 / Bcl2l11 / Bcl-2-like protein 11 / O43521* / BCL2 like 11*  / reaction
 ENSMUSG00000057329 Bcl2 / P10417 / Apoptosis regulator Bcl-2 / P10415* / BCL2, apoptosis regulator*  / reaction / complex
 ENSMUSG00000004446 Bid / P70444 / BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-interacting domain death agonist p11 / P55957* / BH...  / reaction
 ENSMUSG00000022092 P48455 / Ppp3cc / protein phosphatase 3, catalytic subunit, gamma isoform / P48454* / protein phosphatase 3 catalytic subunit gamma*  / reaction
 ENSMUSG00000033953 Ppp3r1 / Q63810 / protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) / P63098* / protein phosphatase 3 regulatory subunit B, alpha*  / reaction






 

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