ENSMUSG00000033953


Mus musculus

Features
Gene ID: ENSMUSG00000033953
  
Biological name :Ppp3r1
  
Synonyms : Ppp3r1 / protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) / Q63810
  
Possible biological names infered from orthology : P63098 / protein phosphatase 3 regulatory subunit B, alpha
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A2
Gene start: 17159263
Gene end: 17200375
  
Corresponding Affymetrix probe sets: 10374415 (MoGene1.0st)   1421786_at (Mouse Genome 430 2.0 Array)   1433591_at (Mouse Genome 430 2.0 Array)   1450368_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099944
NCBI entrez gene - 19058     See in Manteia.
MGI - MGI:107172
RefSeq - NM_024459
RefSeq Peptide - NP_077779
swissprot - Q63810
Ensembl - ENSMUSG00000033953
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp3r1bENSDARG00000069360Danio rerio
 P63098ENSG00000221823Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ppp3r2 / Q63811 / protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) / Q96LZ3* / protein phosphatase 3 regulatory subunit B, beta*ENSMUSG0000002831081
Chp1 / P61022 / Calcineurin B homologous protein 1 / Q99653* / calcineurin like EF-hand protein 1*ENSMUSG0000001407741
Chp2 / Q9D869 / Calcineurin B homologous protein 2 / O43745* / calcineurin like EF-hand protein 2*ENSMUSG0000003086536
Tesc / Q9JKL5 / tescalcin / Q96BS2*ENSMUSG0000002935931
Tescl / TESC* / Q96BS2* / tescalcin*ENSMUSG0000005582628


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IMP
 biological_processGO:0001837 epithelial to mesenchymal transition IMP
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0014044 Schwann cell development IMP
 biological_processGO:0022011 myelination in peripheral nervous system IMP
 biological_processGO:0033173 calcineurin-NFAT signaling cascade IEA
 biological_processGO:0034504 protein localization to nucleus IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060487 lung epithelial cell differentiation IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005955 calcineurin complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0042383 sarcolemma IDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016018 cyclosporin A binding IEA
 molecular_functionGO:0019902 phosphatase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of BAD and translocation to mitochondria
Calcineurin activates NFAT
FCERI mediated Ca+2 mobilization
Ca2+ pathway
CLEC7A (Dectin-1) induces NFAT activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gjb6tm1Kwi/Gjb6+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ppp3r1tm2.1Grc/Ppp3r1tm2.1Grc
Genetic Background: Not Specified

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gjb6tm1Kwi/Gjb6+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Pkd1tm3.2Bol/Pkd1tm3.2Bol
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
Show

Allelic Composition: Gjb6tm1Kwi/Gjb6+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ppp3r1tm2.1Grc/Ppp3r1tm2.1Grc
Genetic Background: Not Specified

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ppp3r1tm2.1Grc/Ppp3r1tm2.1Grc
Genetic Background: Not Specified

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Lcattm1Nsa/Lcat+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001361 social withdrawal "mice remain physically distant, do not sleep in piles with cagemates" [J:57125]
Show

Allelic Composition: Lcattm1Nsa/Lcat+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Lcattm1Nsa/Lcat+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Lcattm1Nsa/Lcat+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lcattm1Nsa/Lcat+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gjb6tm1Kwi/Gjb6+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ppp3r1tm2.1Grc/Ppp3r1tm2.1Grc
Genetic Background: Not Specified

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Gjb6tm1Kwi/Gjb6+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ppp3r1tm2.1Grc/Ppp3r1tm2.1Grc
Genetic Background: Not Specified

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Ppp3r1tm2.1Grc/Ppp3r1tm2.1Grc
Genetic Background: Not Specified

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
Show

Allelic Composition: Gjb6tm1Kwi/Gjb6+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ppp3r1tm2.1Grc/Ppp3r1tm2.1Grc
Genetic Background: Not Specified

 MP:0001723 disorganized vascular plexus 
Show

Allelic Composition: Gjb6tm1Kwi/Gjb6+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ppp3r1tm2.1Grc/Ppp3r1tm2.1Grc
Genetic Background: Not Specified

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Ppp3r1tm2.1Grc/Ppp3r1tm2.1Grc
Genetic Background: Not Specified

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lcattm1Nsa/Lcat+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lcattm1Nsa/Lcat+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gjb6tm1Kwi/Gjb6+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lcattm1Nsa/Lcat+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002635 reduced sensorimotor gating 
Show

Allelic Composition: Lcattm1Nsa/Lcat+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0003542 abnormal vascular endothelial cell development "malformation or aberrant differentiation of the cells that line the vasculature" [J:95387, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pkd1tm3.2Bol/Pkd1tm3.2Bol
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0003672 abnormal ureter development "anomalous differentiation of the tube that conducts the urine from the renal pelvis to the bladder" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96485]
Show

Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0004194 abnormal kidney pelvis morphology "any structural anomaly of the funnel shaped proximal portion of the ureter that is formed by convergence of the major calices" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
Show

Allelic Composition: Ppp3r1tm2.1Grc/Ppp3r1tm2.1Grc
Genetic Background: Not Specified

 MP:0004970 kidney atrophy "wasting of the kidney due to injury or disease, resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ppp3r1tm2.1Grc/Ppp3r1tm2.1Grc
Genetic Background: Not Specified

 MP:0006299 abnormal latent inhibition of conditioning behavior "anomaly in the impairment in a conditioned response seen after repeated unpaired presentations of the conditioned stimulus prior to pairing it with the unconditioned stimulus" [Additction research lab:http://dionysus.psych.wisc.edu/ARL/research-current.html, brs:Beverly Richards-Smith_IMSR Curator, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lcattm1Nsa/Lcat+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lcattm1Nsa/Lcat+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Ppp3r1tm2.1Grc/Ppp3r1tm2.1Grc
Genetic Background: Not Specified

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Ppp3r1tm2.1Grc/Ppp3r1tm2.1Grc
Genetic Background: Not Specified

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Gjb6tm1Kwi/Gjb6+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ppp3r1tm2.1Grc/Ppp3r1tm2.1Grc
Genetic Background: Not Specified

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Pkd1tm3.2Bol/Pkd1tm3.2Bol
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac

 MP:0011305 dilated kidney calyx "an expansion in the lumen volume or area of any of the branches of the renal pelvis that surround each renal papilla and collect urine" [MGI:anna]
Show

Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0011480 impaired ureteric peristalsis "any anomaly in the wavelike sequence of involuntary muscular contraction and relaxation that passes along the ureter, thus propelling urine from the kidney pelvis to the urinary bladder" [MGI:anna]
Show

Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0011491 ureteropelvic junction obstruction "a partial or total blockage of the flow of urine through the junction of the renal pelvis and the proximal ureter" [MGI:anna]
Show

Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / complex / reaction
 ENSMUSG00000021816 P48453 / Ppp3cb / protein phosphatase 3, catalytic subunit, beta isoform / P16298* / protein phosphatase 3 catalytic subunit beta*  / complex
 ENSMUSG00000033016 Nfatc1 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 / O95644* / nuclear factor of activated T cells 1*  / complex / reaction
 ENSMUSG00000027544 Nfatc2 / Q60591 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 / Q13469* / nuclear factor of activated T cells 2*  / complex / reaction
 ENSMUSG00000028161 P63328 / Ppp3ca / protein phosphatase 3, catalytic subunit, alpha isoform / Q08209* / protein phosphatase 3 catalytic subunit alpha*  / complex
 ENSMUSG00000022092 P48455 / Ppp3cc / protein phosphatase 3, catalytic subunit, gamma isoform / P48454* / protein phosphatase 3 catalytic subunit gamma*  / complex
 ENSMUSG00000031902 Nfatc3 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 / Q12968* / nuclear factor of activated T cells 3*  / complex / reaction
 ENSMUSG00000024959 Bad / Q61337 / Bcl2-associated agonist of cell death / Q92934*  / reaction






 

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