ENSG00000221823


Homo sapiens

Features
Gene ID: ENSG00000221823
  
Biological name :PPP3R1
  
Synonyms : P63098 / PPP3R1 / protein phosphatase 3 regulatory subunit B, alpha
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p14
Gene start: 68178857
Gene end: 68256237
  
Corresponding Affymetrix probe sets: 204506_at (Human Genome U133 Plus 2.0 Array)   204507_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000234310
Ensembl peptide - ENSP00000387216
Ensembl peptide - ENSP00000387148
NCBI entrez gene - 5534     See in Manteia.
OMIM - 601302
RefSeq - NM_000945
RefSeq Peptide - NP_000936
swissprot - D3YTA9
swissprot - F6U1T9
swissprot - P63098
Ensembl - ENSG00000221823
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp3r1bENSDARG00000069360Danio rerio
 Ppp3r1ENSMUSG00000033953Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AC017083.3ENSG0000027339886
PPP3R2 / Q96LZ3 / protein phosphatase 3 regulatory subunit B, betaENSG0000018838685
CHP1 / Q99653 / calcineurin like EF-hand protein 1ENSG0000018744641
CHP2 / O43745 / calcineurin like EF-hand protein 2ENSG0000016686935
TESC / Q96BS2 / tescalcinENSG0000008899232


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IEA
 biological_processGO:0001837 epithelial to mesenchymal transition IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway TAS
 biological_processGO:0007507 heart development IEA
 biological_processGO:0014044 Schwann cell development IEA
 biological_processGO:0022011 myelination in peripheral nervous system IEA
 biological_processGO:0033173 calcineurin-NFAT signaling cascade IEA
 biological_processGO:0034504 protein localization to nucleus IEA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0060487 lung epithelial cell differentiation IEA
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005955 calcineurin complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0042383 sarcolemma IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004723 calcium-dependent protein serine/threonine phosphatase activity NAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding NAS
 molecular_functionGO:0016018 cyclosporin A binding IDA
 molecular_functionGO:0019902 phosphatase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of BAD and translocation to mitochondria
DARPP-32 events
Calcineurin activates NFAT
FCERI mediated Ca+2 mobilization
Ca2+ pathway
CLEC7A (Dectin-1) induces NFAT activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000131196 NFATC1 / O95644 / nuclear factor of activated T cells 1  / complex / reaction
 ENSG00000138814 PPP3CA / Q08209 / protein phosphatase 3 catalytic subunit alpha  / complex
 ENSG00000002330 BAD / Q92934 / BCL2 associated agonist of cell death  / reaction
 ENSG00000120910 P48454 / PPP3CC / protein phosphatase 3 catalytic subunit gamma  / complex
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / complex / reaction
 ENSG00000101096 NFATC2 / Q13469 / nuclear factor of activated T cells 2  / complex / reaction
 ENSG00000107758 P16298 / PPP3CB / protein phosphatase 3 catalytic subunit beta  / complex
 ENSG00000072736 NFATC3 / Q12968 / nuclear factor of activated T cells 3  / complex / reaction






 

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