ENSG00000101096


Homo sapiens

Features
Gene ID: ENSG00000101096
  
Biological name :NFATC2
  
Synonyms : NFATC2 / nuclear factor of activated T cells 2 / Q13469
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q13.2
Gene start: 51386957
Gene end: 51562831
  
Corresponding Affymetrix probe sets: 224542_s_at (Human Genome U133 Plus 2.0 Array)   226991_at (Human Genome U133 Plus 2.0 Array)   228442_at (Human Genome U133 Plus 2.0 Array)   231801_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000360619
Ensembl peptide - ENSP00000379330
Ensembl peptide - ENSP00000396471
Ensembl peptide - ENSP00000477142
Ensembl peptide - ENSP00000477342
Ensembl peptide - ENSP00000477370
NCBI entrez gene - 4773     See in Manteia.
OMIM - 600490
RefSeq - NM_173091
RefSeq - XM_017027851
RefSeq - NM_001136021
RefSeq - NM_001258292
RefSeq - NM_001258294
RefSeq - NM_001258295
RefSeq - NM_001258296
RefSeq - NM_001258297
RefSeq - NM_012340
RefSeq - XM_011528824
RefSeq - XM_011528825
RefSeq - XM_011528826
RefSeq - XM_017027850
RefSeq Peptide - NP_001245225
RefSeq Peptide - NP_036472
RefSeq Peptide - NP_775114
RefSeq Peptide - NP_001245226
RefSeq Peptide - NP_001129493
RefSeq Peptide - NP_001245221
RefSeq Peptide - NP_001245223
RefSeq Peptide - NP_001245224
swissprot - Q13469
Ensembl - ENSG00000101096
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfatc2aENSDARG00000100927Danio rerio
 nfatc2bENSDARG00000079972Danio rerio
 NFATC2ENSGALG00000007963Gallus gallus
 Nfatc2ENSMUSG00000027544Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NFATC1 / O95644 / nuclear factor of activated T cells 1ENSG0000013119645
NFATC3 / Q12968 / nuclear factor of activated T cells 3ENSG0000007273638
NFATC4 / Q14934 / nuclear factor of activated T cells 4ENSG0000010096833
NFAT5 / O94916 / nuclear factor of activated T cells 5ENSG0000010290824


Protein motifs (from Interpro)
Interpro ID Name
 IPR002909  IPT domain
 IPR008366  Nuclear factor of activated T cells (NFAT)
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR032397  Rel homology dimerisation domain
 IPR037059  Rel homology domain (RHD), DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001816 cytokine production IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014904 myotube cell development IEA
 biological_processGO:0016477 cell migration IDA
 biological_processGO:0030890 positive regulation of B cell proliferation IMP
 biological_processGO:0033173 calcineurin-NFAT signaling cascade IEA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0042493 response to drug IMP
 biological_processGO:0045589 regulation of regulatory T cell differentiation TAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050853 B cell receptor signaling pathway IMP
 biological_processGO:1901741 positive regulation of myoblast fusion IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0044798 nuclear transcription factor complex IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019902 phosphatase binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
Calcineurin activates NFAT
FCERI mediated Ca+2 mobilization
CLEC7A (Dectin-1) induces NFAT activation
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000221823 P63098 / PPP3R1 / protein phosphatase 3 regulatory subunit B, alpha  / complex / reaction
 ENSG00000067955 CBFB / Q13951 / core-binding factor beta subunit  / complex / reaction
 ENSG00000159216 RUNX1 / Q01196 / runt related transcription factor 1  / complex / reaction
 ENSG00000138814 PPP3CA / Q08209 / protein phosphatase 3 catalytic subunit alpha  / complex / reaction
 ENSG00000107758 P16298 / PPP3CB / protein phosphatase 3 catalytic subunit beta  / complex / reaction
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / reaction / complex
 ENSG00000049768 FOXP3 / Q9BZS1 / forkhead box P3  / complex / reaction






 

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