ENSG00000138814


Homo sapiens

Features
Gene ID: ENSG00000138814
  
Biological name :PPP3CA
  
Synonyms : PPP3CA / protein phosphatase 3 catalytic subunit alpha / Q08209
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q24
Gene start: 101023409
Gene end: 101348278
  
Corresponding Affymetrix probe sets: 202425_x_at (Human Genome U133 Plus 2.0 Array)   202429_s_at (Human Genome U133 Plus 2.0 Array)   202457_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000378322
Ensembl peptide - ENSP00000378323
Ensembl peptide - ENSP00000434599
Ensembl peptide - ENSP00000431619
Ensembl peptide - ENSP00000426565
Ensembl peptide - ENSP00000422990
Ensembl peptide - ENSP00000422781
Ensembl peptide - ENSP00000320580
NCBI entrez gene - 5530     See in Manteia.
OMIM - 114105
RefSeq - XM_017008365
RefSeq - NM_000944
RefSeq - NM_001130691
RefSeq - NM_001130692
RefSeq Peptide - NP_001124164
RefSeq Peptide - NP_000935
RefSeq Peptide - NP_001124163
swissprot - E9PPC8
swissprot - E9PK68
swissprot - E7ETC2
swissprot - A0A0S2Z4B5
swissprot - A0A0S2Z4C6
swissprot - H0YAB4
swissprot - Q08209
Ensembl - ENSG00000138814
  
Related genetic diseases (OMIM): 617711 - Epileptic encephalopathy, infantile or early childhood, 1, 617711
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp3caENSDARG00000004988Danio rerio
 ppp3cbENSDARG00000025106Danio rerio
 PPP3CAENSGALG00000039498Gallus gallus
 P63328ENSMUSG00000028161Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P16298 / PPP3CB / protein phosphatase 3 catalytic subunit betaENSG0000010775882
P48454 / PPP3CC / protein phosphatase 3 catalytic subunit gammaENSG0000012091078


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR006186  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006606 protein import into nucleus IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway TAS
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0014883 transition between fast and slow fiber IEA
 biological_processGO:0014898 cardiac muscle hypertrophy in response to stress IEA
 biological_processGO:0016311 dephosphorylation TAS
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0033173 calcineurin-NFAT signaling cascade IMP
 biological_processGO:0033555 multicellular organismal response to stress IEA
 biological_processGO:0035562 negative regulation of chromatin binding IEA
 biological_processGO:0035690 cellular response to drug IDA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0042110 T cell activation TAS
 biological_processGO:0045807 positive regulation of endocytosis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0048741 skeletal muscle fiber development IEA
 biological_processGO:0050774 negative regulation of dendrite morphogenesis IEA
 biological_processGO:0050804 modulation of chemical synaptic transmission IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051592 response to calcium ion IDA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress IEA
 biological_processGO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA IEA
 biological_processGO:1905205 positive regulation of connective tissue replacement IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005955 calcineurin complex NAS
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity NAS
 molecular_functionGO:0004723 calcium-dependent protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0005509 calcium ion binding NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding NAS
 molecular_functionGO:0008144 drug binding IDA
 molecular_functionGO:0016018 cyclosporin A binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IDA
 molecular_functionGO:0033192 calmodulin-dependent protein phosphatase activity TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IPI


Pathways (from Reactome)
Pathway description
DARPP-32 events
Calcineurin activates NFAT
FCERI mediated Ca+2 mobilization
Ca2+ pathway
CLEC7A (Dectin-1) induces NFAT activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000131196 NFATC1 / O95644 / nuclear factor of activated T cells 1  / complex / reaction
 ENSG00000221823 P63098 / PPP3R1 / protein phosphatase 3 regulatory subunit B, alpha  / complex
 ENSG00000072736 NFATC3 / Q12968 / nuclear factor of activated T cells 3  / reaction / complex
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / complex / reaction
 ENSG00000101096 NFATC2 / Q13469 / nuclear factor of activated T cells 2  / complex / reaction






 

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