ENSG00000072736


Homo sapiens

Features
Gene ID: ENSG00000072736
  
Biological name :NFATC3
  
Synonyms : NFATC3 / nuclear factor of activated T cells 3 / Q12968
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q22.1
Gene start: 68084751
Gene end: 68229259
  
Corresponding Affymetrix probe sets: 207416_s_at (Human Genome U133 Plus 2.0 Array)   210555_s_at (Human Genome U133 Plus 2.0 Array)   210556_at (Human Genome U133 Plus 2.0 Array)   225137_at (Human Genome U133 Plus 2.0 Array)   225139_at (Human Genome U133 Plus 2.0 Array)   225141_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000456307
Ensembl peptide - ENSP00000460533
Ensembl peptide - ENSP00000457441
Ensembl peptide - ENSP00000456379
Ensembl peptide - ENSP00000264008
Ensembl peptide - ENSP00000300659
Ensembl peptide - ENSP00000331324
Ensembl peptide - ENSP00000445670
Ensembl peptide - ENSP00000454451
Ensembl peptide - ENSP00000455113
Ensembl peptide - ENSP00000456120
NCBI entrez gene - 4775     See in Manteia.
OMIM - 602698
RefSeq - NM_173163
RefSeq - NM_173165
RefSeq - NM_004555
RefSeq Peptide - NP_004546
RefSeq Peptide - NP_775186
RefSeq Peptide - NP_775188
swissprot - I3L3K7
swissprot - B5B2S1
swissprot - Q12968
swissprot - B5B2S0
swissprot - F8VPH9
swissprot - H3BR83
swissprot - H3BRM3
swissprot - H3BRS1
swissprot - H3BU30
Ensembl - ENSG00000072736
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfatc3aENSDARG00000076297Danio rerio
 NFATC3ENSGALG00000003396Gallus gallus
 Nfatc3ENSMUSG00000031902Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NFATC4 / Q14934 / nuclear factor of activated T cells 4ENSG0000010096836
NFATC1 / O95644 / nuclear factor of activated T cells 1ENSG0000013119635
NFATC2 / Q13469 / nuclear factor of activated T cells 2ENSG0000010109632
NFAT5 / O94916 / nuclear factor of activated T cells 5ENSG0000010290824


Protein motifs (from Interpro)
Interpro ID Name
 IPR002909  IPT domain
 IPR008366  Nuclear factor of activated T cells (NFAT)
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR032397  Rel homology dimerisation domain
 IPR037059  Rel homology domain (RHD), DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IGI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Calcineurin activates NFAT
FCERI mediated Ca+2 mobilization
CLEC7A (Dectin-1) induces NFAT activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000221823 P63098 / PPP3R1 / protein phosphatase 3 regulatory subunit B, alpha  / complex / reaction
 ENSG00000107758 P16298 / PPP3CB / protein phosphatase 3 catalytic subunit beta  / reaction / complex
 ENSG00000138814 PPP3CA / Q08209 / protein phosphatase 3 catalytic subunit alpha  / complex / reaction
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / complex / reaction






 

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