ENSG00000102908


Homo sapiens

Features
Gene ID: ENSG00000102908
  
Biological name :NFAT5
  
Synonyms : NFAT5 / nuclear factor of activated T cells 5 / O94916
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q22.1
Gene start: 69565094
Gene end: 69704666
  
Corresponding Affymetrix probe sets: 208003_s_at (Human Genome U133 Plus 2.0 Array)   215092_s_at (Human Genome U133 Plus 2.0 Array)   224984_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000463214
Ensembl peptide - ENSP00000462061
Ensembl peptide - ENSP00000486610
Ensembl peptide - ENSP00000338806
Ensembl peptide - ENSP00000346420
Ensembl peptide - ENSP00000377343
Ensembl peptide - ENSP00000413126
Ensembl peptide - ENSP00000455115
Ensembl peptide - ENSP00000455628
Ensembl peptide - ENSP00000457593
NCBI entrez gene - 10725     See in Manteia.
OMIM - 604708
RefSeq - XM_017022873
RefSeq - NM_138714
RefSeq - NM_173214
RefSeq - NM_173215
RefSeq - XM_006721125
RefSeq - XM_011522817
RefSeq - XM_011522818
RefSeq - XM_011522819
RefSeq - XM_011522820
RefSeq - XM_011522822
RefSeq - XM_017022870
RefSeq - XM_017022871
RefSeq - XM_017022872
RefSeq - NM_001113178
RefSeq - NM_006599
RefSeq - NM_138713
RefSeq Peptide - NP_006590
RefSeq Peptide - NP_619727
RefSeq Peptide - NP_619728
RefSeq Peptide - NP_775321
RefSeq Peptide - NP_775322
RefSeq Peptide - NP_001106649
swissprot - A0A024R734
swissprot - H3BP21
swissprot - J3KRL6
swissprot - J3QKS5
swissprot - F6X8W2
swissprot - O94916
Ensembl - ENSG00000102908
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfat5aENSDARG00000020872Danio rerio
 nfat5bENSDARG00000102556Danio rerio
 NFAT5ENSGALG00000039300Gallus gallus
 Nfat5ENSMUSG00000003847Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NFATC3 / Q12968 / nuclear factor of activated T cells 3ENSG0000007273617
NFATC2 / Q13469 / nuclear factor of activated T cells 2ENSG0000010109614
NFATC1 / O95644 / nuclear factor of activated T cells 1ENSG0000013119614
NFATC4 / Q14934 / nuclear factor of activated T cells 4ENSG0000010096811


Protein motifs (from Interpro)
Interpro ID Name
 IPR002909  IPT domain
 IPR008366  Nuclear factor of activated T cells (NFAT)
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015646  Nuclear factor of activated T-cells 5
 IPR032397  Rel homology dimerisation domain
 IPR037059  Rel homology domain (RHD), DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007588 excretion TAS
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0070884 regulation of calcineurin-NFAT signaling cascade IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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