ENSG00000100968


Homo sapiens

Features
Gene ID: ENSG00000100968
  
Biological name :NFATC4
  
Synonyms : NFATC4 / nuclear factor of activated T cells 4 / Q14934
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q12
Gene start: 24365673
Gene end: 24379604
  
Corresponding Affymetrix probe sets: 205897_at (Human Genome U133 Plus 2.0 Array)   213345_at (Human Genome U133 Plus 2.0 Array)   236270_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450810
Ensembl peptide - ENSP00000396788
Ensembl peptide - ENSP00000439350
Ensembl peptide - ENSP00000450469
Ensembl peptide - ENSP00000450590
Ensembl peptide - ENSP00000450644
Ensembl peptide - ENSP00000450686
Ensembl peptide - ENSP00000450733
Ensembl peptide - ENSP00000451151
Ensembl peptide - ENSP00000451183
Ensembl peptide - ENSP00000451224
Ensembl peptide - ENSP00000451284
Ensembl peptide - ENSP00000451395
Ensembl peptide - ENSP00000451454
Ensembl peptide - ENSP00000451496
Ensembl peptide - ENSP00000451502
Ensembl peptide - ENSP00000451590
Ensembl peptide - ENSP00000451801
Ensembl peptide - ENSP00000451853
Ensembl peptide - ENSP00000451992
Ensembl peptide - ENSP00000452039
Ensembl peptide - ENSP00000452270
Ensembl peptide - ENSP00000452349
Ensembl peptide - ENSP00000452352
Ensembl peptide - ENSP00000250373
Ensembl peptide - ENSP00000388668
Ensembl peptide - ENSP00000388910
NCBI entrez gene - 4776     See in Manteia.
OMIM - 602699
RefSeq - NM_001198966
RefSeq - NM_001198967
RefSeq - XM_011536798
RefSeq - XM_011536799
RefSeq - NM_004554
RefSeq - NM_001320043
RefSeq - NM_001288802
RefSeq - NM_001136022
RefSeq - NM_001198965
RefSeq - XM_011536797
RefSeq Peptide - NP_001306972
RefSeq Peptide - NP_004545
RefSeq Peptide - NP_001185894
RefSeq Peptide - NP_001185895
RefSeq Peptide - NP_001185896
RefSeq Peptide - NP_001275731
RefSeq Peptide - NP_001129494
swissprot - G3V5H0
swissprot - G3V4U6
swissprot - G3V4K1
swissprot - Q14934
Ensembl - ENSG00000100968
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfatc4ENSDARG00000054162Danio rerio
 Nfatc4ENSMUSG00000023411Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NFATC3 / Q12968 / nuclear factor of activated T cells 3ENSG0000007273641
NFATC1 / O95644 / nuclear factor of activated T cells 1ENSG0000013119633
NFATC2 / Q13469 / nuclear factor of activated T cells 2ENSG0000010109631
NFAT5 / O94916 / nuclear factor of activated T cells 5ENSG0000010290818


Protein motifs (from Interpro)
Interpro ID Name
 IPR002909  IPT domain
 IPR008366  Nuclear factor of activated T cells (NFAT)
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR032397  Rel homology dimerisation domain
 IPR037059  Rel homology domain (RHD), DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0033173 calcineurin-NFAT signaling cascade IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0035562 negative regulation of chromatin binding IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045333 cellular respiration IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048167 regulation of synaptic plasticity IEA
 biological_processGO:0050774 negative regulation of dendrite morphogenesis IEA
 biological_processGO:0051145 smooth muscle cell differentiation IEA
 biological_processGO:0055001 muscle cell development IEA
 biological_processGO:0071285 cellular response to lithium ion IEA
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II IGI
 biological_processGO:1904637 cellular response to ionomycin IEA
 biological_processGO:2000297 negative regulation of synapse maturation IEA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IGI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0042975 peroxisome proliferator activated receptor binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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