ENSG00000131196


Homo sapiens

Features
Gene ID: ENSG00000131196
  
Biological name :NFATC1
  
Synonyms : NFATC1 / nuclear factor of activated T cells 1 / O95644
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: 1
Band: q23
Gene start: 79395856
Gene end: 79529325
  
Corresponding Affymetrix probe sets: 208196_x_at (Human Genome U133 Plus 2.0 Array)   209664_x_at (Human Genome U133 Plus 2.0 Array)   210162_s_at (Human Genome U133 Plus 2.0 Array)   211105_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468111
Ensembl peptide - ENSP00000467181
Ensembl peptide - ENSP00000467615
Ensembl peptide - ENSP00000253506
Ensembl peptide - ENSP00000316553
Ensembl peptide - ENSP00000327850
Ensembl peptide - ENSP00000380892
Ensembl peptide - ENSP00000389377
Ensembl peptide - ENSP00000439992
Ensembl peptide - ENSP00000442435
Ensembl peptide - ENSP00000466194
Ensembl peptide - ENSP00000466489
NCBI entrez gene - 4772     See in Manteia.
OMIM - 600489
RefSeq - XM_017025783
RefSeq - NM_001278669
RefSeq - NM_001278670
RefSeq - NM_001278672
RefSeq - NM_001278673
RefSeq - NM_001278675
RefSeq - NM_006162
RefSeq - NM_172387
RefSeq - NM_172388
RefSeq - NM_172389
RefSeq - NM_172390
RefSeq Peptide - NP_765978
RefSeq Peptide - NP_006153
RefSeq Peptide - NP_765975
RefSeq Peptide - NP_765976
RefSeq Peptide - NP_765977
RefSeq Peptide - NP_001265598
RefSeq Peptide - NP_001265599
RefSeq Peptide - NP_001265601
RefSeq Peptide - NP_001265602
RefSeq Peptide - NP_001265604
swissprot - F5H4S8
swissprot - K7ER53
swissprot - O95644
swissprot - K7EQ04
Ensembl - ENSG00000131196
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfatc1ENSDARG00000036168Danio rerio
 NFATC1ENSGALG00000042534Gallus gallus
 Nfatc1ENSMUSG00000033016Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NFATC2 / Q13469 / nuclear factor of activated T cells 2ENSG0000010109644
NFATC3 / Q12968 / nuclear factor of activated T cells 3ENSG0000007273640
NFATC4 / Q14934 / nuclear factor of activated T cells 4ENSG0000010096834
NFAT5 / O94916 / nuclear factor of activated T cells 5ENSG0000010290824


Protein motifs (from Interpro)
Interpro ID Name
 IPR002909  IPT domain
 IPR008366  Nuclear factor of activated T cells (NFAT)
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015647  Nuclear factor of activated T-cells 1
 IPR032397  Rel homology dimerisation domain
 IPR037059  Rel homology domain (RHD), DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway TAS
 biological_processGO:0030178 negative regulation of Wnt signaling pathway ISS
 biological_processGO:0033173 calcineurin-NFAT signaling cascade IDA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016604 nuclear body IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding ISS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding ISS
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding ISS
 molecular_functionGO:0001225 RNA polymerase II transcription coactivator binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005528 FK506 binding TAS
 molecular_functionGO:0048273 mitogen-activated protein kinase p38 binding ISS


Pathways (from Reactome)
Pathway description
Calcineurin activates NFAT
FCERI mediated Ca+2 mobilization
Ca2+ pathway
CLEC7A (Dectin-1) induces NFAT activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / reaction / complex
 ENSG00000138814 PPP3CA / Q08209 / protein phosphatase 3 catalytic subunit alpha  / reaction / complex
 ENSG00000221823 P63098 / PPP3R1 / protein phosphatase 3 regulatory subunit B, alpha  / reaction / complex
 ENSG00000107758 P16298 / PPP3CB / protein phosphatase 3 catalytic subunit beta  / reaction / complex






 

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© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr