Manteia - Molecule gene

ENSMUSG00000033016

Mus musculus

Features

Gene ID:	ENSMUSG00000033016

Biological name :	Nfatc1

Synonyms :	Nfatc1 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1

Possible biological names infered from orthology :	nuclear factor of activated T cells 1 / O95644

Species:	Mus musculus

Chr. number:	18
Strand:	-1
Band:	E3
Gene start:	80606205
Gene end:	80713071

Corresponding Affymetrix probe sets:	10459944 (MoGene1.0st) 1417621_at (Mouse Genome 430 2.0 Array) 1425761_a_at (Mouse Genome 430 2.0 Array) 1428479_at (Mouse Genome 430 2.0 Array) 1447084_at (Mouse Genome 430 2.0 Array) 1447085_s_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000129001 Ensembl peptide - ENSMUSP00000046312 Ensembl peptide - ENSMUSP00000077196 Ensembl peptide - ENSMUSP00000126884 NCBI entrez gene - 18018 See in Manteia. MGI - MGI:102469 RefSeq - NM_001164112 RefSeq - NM_001164109 RefSeq - NM_001164110 RefSeq - NM_001164111 RefSeq - NM_016791 RefSeq - NM_198429 RefSeq Peptide - NP_001157584 RefSeq Peptide - NP_058071 RefSeq Peptide - NP_940821 RefSeq Peptide - NP_001157582 RefSeq Peptide - NP_001157583 RefSeq Peptide - NP_001157581 swissprot - B5B2N2 swissprot - Q9DBQ6 swissprot - B5B2N7 swissprot - Q6P7T9 Ensembl - ENSMUSG00000033016

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
nfatc1	ENSDARG00000036168	Danio rerio
NFATC1	ENSGALG00000042534	Gallus gallus
NFATC1	ENSG00000131196	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Nfatc2 / Q60591 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 / Q13469* / nuclear factor of activated T cells 2*	ENSMUSG00000027544	43
Nfatc3 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 / Q12968* / nuclear factor of activated T cells 3*	ENSMUSG00000031902	42
Nfatc4 / Q8K120 / Nuclear factor of activated T-cells, cytoplasmic 4 / Q14934* / nuclear factor of activated T cells 4*	ENSMUSG00000023411	33
Nfat5 / Q9WV30 / nuclear factor of activated T cells 5 / O94916*	ENSMUSG00000003847	24

Protein motifs (from Interpro)

Interpro ID	Name
IPR002909	IPT domain
IPR008366	Nuclear factor of activated T cells (NFAT)
IPR008967	p53-like transcription factor, DNA-binding
IPR011539	Rel homology domain (RHD), DNA-binding domain
IPR013783	Immunoglobulin-like fold
IPR014756	Immunoglobulin E-set
IPR015647	Nuclear factor of activated T-cells 1
IPR032397	Rel homology dimerisation domain
IPR037059	Rel homology domain (RHD), DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0033173	calcineurin-NFAT signaling cascade	IEA
biological_process	GO:0035556	intracellular signal transduction	IEA
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
cellular_component	GO:0000790	nuclear chromatin	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0016604	nuclear body	IEA
molecular_function	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IEA
molecular_function	GO:0001225	RNA polymerase II transcription coactivator binding	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA

Pathways (from Reactome)

Pathway description

Calcineurin activates NFAT

FCERI mediated Ca+2 mobilization

CLEC7A (Dectin-1) induces NFAT activation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000067	osteopetrosis	"excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Hdac3^tm1.2Eno/Hdac3^tm1.2Eno Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0000260	abnormal angiogenesis	"aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Vegfa^tm2Gne/Vegfa^tm2Gne,Tg(Tnnt2-cre)5Blh/0 Genetic Background: involves: 129/Sv * C57BL/6 * DBA Allelic Composition: Kdr^tm1Wag/Kdr^tm1Wag,Nfatc1^tm1.1(cre)Bz/Nfatc1⁺,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Grid2^ho-cpr/Grid2^ho-cpr Genetic Background: involves: C57BL/10J * DBA/2J
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Ntrk1^tm1.1Azmo/Ntrk1^tm1.1Azmo Genetic Background: involves: 129S2/SvPas Allelic Composition: Nfatc1^tm1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MP:0000281	abnormal ventricular septum morphology	"abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Fos^tm1Wag/Fos^tm1Wag,Trp53^tm1Tyj/Trp53⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Kdr^tm1Wag/Kdr^tm1Wag,Nfatc1^tm1.1(cre)Bz/Nfatc1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000285	abnormal cardiac valve morphology	"malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]	Show Allelic Composition: Tbx20^tm1Sev/Tbx20^tm1.1Sev,Nfatc1^tm1.1(cre)Bz/Nfatc1⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss
MP:0000286	abnormal mitral valve morphology	"malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Fos^tm1Wag/Fos^tm1Wag,Trp53^tm1Tyj/Trp53⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000301	reduced size of endocardial cushions	"smaller than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]	Show Allelic Composition: Nfatc1^tm1Glm/Nfatc1^tm1Glm,H2afv^{Tg(Wnt1-cre)11Rth}/0,Gt(ROSA)26Sor^tm1Sho/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * CBA Allelic Composition: Tbx20^tm1Sev/Tbx20^tm1.1Sev,Nfatc1^tm1.1(cre)Bz/Nfatc1⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss
MP:0000465	gastrointestinal hemorrhage	"bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Nfatc1^tm1Glm/Nfatc1^tm1Glm Genetic Background: involves: 129S2/SvPas
MP:0000717	abnormal lymphocyte number	"deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Vegfa^tm2Gne/Vegfa^tm2Gne,Tg(Tnnt2-cre)5Blh/0 Genetic Background: involves: 129/Sv * C57BL/6 * DBA
MP:0001544	abnormal cardiovascular system physiology	"anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Grid2^ho-cpr/Grid2^ho-cpr Genetic Background: involves: C57BL/10J * DBA/2J Allelic Composition: Tbx20^tm1Sev/Tbx20^tm1.1Sev,Nfatc1^tm1.1(cre)Bz/Nfatc1⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Fos^tm1Wag/Fos^tm1Wag,Trp53^tm1Tyj/Trp53⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001625	cardiac hypertrophy	"an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fos^tm1Wag/Fos^tm1Wag,Trp53^tm1Tyj/Trp53⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Fos^tm1Wag/Fos^tm1Wag,Trp53^tm1Tyj/Trp53⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Nfatc1^tm1Glm/Nfatc1^tm1Glm Genetic Background: involves: 129S2/SvPas
MP:0001790	abnormal immune system physiology	"deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0001806	decreased IgM	"less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Tg(Fcer2a-cre)5Mbu/0 Genetic Background: involves: C57BL/6 * CBA
MP:0001860	liver inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Nfatc1^tm3Glm/Nfatc1^tm3Glm,Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0001861	lung inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Nfatc1^tm3Glm/Nfatc1^tm3Glm,Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0001873	stomach inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Nfatc1^tm3Glm/Nfatc1^tm3Glm,Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0001914	hemorrhage	"loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Tbx20^tm1Sev/Tbx20^tm1.1Sev,Nfatc1^tm1.1(cre)Bz/Nfatc1⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss
MP:0002081	perinatal lethality	"death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ntrk1^tm1.1Azmo/Ntrk1^tm1.1Azmo Genetic Background: involves: 129S2/SvPas
MP:0002128	abnormal blood circulation	"failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Grid2^ho-cpr/Grid2^ho-cpr Genetic Background: involves: C57BL/10J * DBA/2J
MP:0002444	abnormal T cell physiology	"anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0002459	abnormal B cell physiology	"abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Tg(Fcer2a-cre)5Mbu/0 Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Nfatc2^tm1Rao/Nfatc2^tm1Rao,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c
MP:0002460	decreased circulating immunoglobulin concentration	"less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0002461	increased circulating immunoglobulin concentration	"greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0002490	abnormal circulating immunoglobulin concentration	"deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0002492	decreased IgE	"less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0002494	increased IgM	"greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Tg(Fcer2a-cre)5Mbu/0 Genetic Background: involves: C57BL/6 * CBA
MP:0002495	increased IgA	"greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0002624	abnormal tricuspid valve morphology	"malformation of the valve with three cusps located between the right atrium and the right ventricle of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Fos^tm1Wag/Fos^tm1Wag,Trp53^tm1Tyj/Trp53⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0002745	abnormal atrioventricular valve morphology	"malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Tbx20^tm1Sev/Tbx20^tm1.1Sev,Nfatc1^tm1.1(cre)Bz/Nfatc1⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss
MP:0002746	abnormal semilunar valve morphology	"malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728]	Show Allelic Composition: Fos^tm1Wag/Fos^tm1Wag,Trp53^tm1Tyj/Trp53⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Nfatc1^tm1Glm/Nfatc1^tm1Glm Genetic Background: involves: 129S2/SvPas Allelic Composition: Nfatc1^tm1Glm/Nfatc1^tm1Glm Genetic Background: B6.129S2-Nfatc1^tm1Glm Allelic Composition: Tbx20^tm1Sev/Tbx20^tm1.1Sev,Nfatc1^tm1.1(cre)Bz/Nfatc1⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss Allelic Composition: Nfatc1^tm1.1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺,Nfatc1^tm1.1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MP:0002747	abnormal aortic valve morphology	"malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Nfatc1^tm1.1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ Allelic Composition: Nfatc1^tm1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MP:0002764	short tibia	" reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Hdac3^tm1.2Eno/Hdac3^tm1.2Eno Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0003109	short femur	"reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Hdac3^tm1.2Eno/Hdac3^tm1.2Eno Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0003408	increased width of hypertrophic chondrocyte zone	"increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Hdac3^tm1.2Eno/Hdac3^tm1.2Eno Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Nfatc1^tm1Glm/Nfatc1^tm1Glm Genetic Background: involves: 129S2/SvPas
MP:0003865	lymph node inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lymph nodes" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Nfatc1^tm3Glm/Nfatc1^tm3Glm,Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0003945	abnormal lymphocyte physiology	"abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0004111	abnormal coronary artery morphology	"anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Kdr^tm1Wag/Kdr^tm1Wag,Nfatc1^tm1.1(cre)Bz/Nfatc1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Kdr^tm1Wag/Kdr^tm1Wag,Nfatc1^tm1.1(cre)Bz/Nfatc1⁺,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 Allelic Composition: Nfatc1^tm1.1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MP:0004595	abnormal mandibular condyloid process morphology	"any structural anomaly of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hdac3^tm1.2Eno/Hdac3^tm1.2Eno Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0004686	decreased length of long bones	"reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hdac3^tm1.2Eno/Hdac3^tm1.2Eno Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0004791	absent lower incisors	"missing the lower pair of long pointed teeth that are the most anterior and prominent in the jaw" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hdac3^tm1.2Eno/Hdac3^tm1.2Eno Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0004800	decreased susceptibility to experimental autoimmune encephalomyelitis	"reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c
MP:0004816	abnormal class switch recombination	"anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Tg(Fcer2a-cre)5Mbu/0 Genetic Background: involves: C57BL/6 * CBA
MP:0004985	decreased osteoclast cell number	"reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hdac3^tm1.2Eno/Hdac3^tm1.2Eno Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Nfatc1^tm3Glm/Nfatc1^tm3Glm,Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0005016	decreased lymphocyte number	"fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c
MP:0005090	increased double-negative T cells count	"greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0005093	impaired B cell proliferation	"absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Tg(Fcer2a-cre)5Mbu/0 Genetic Background: involves: C57BL/6 * CBA
MP:0005294	abnormal heart ventricle morphology	"structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nfatc1^tm1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MP:0005312	pericardial effusion	"escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nfatc1^tm1Glm/Nfatc1^tm1Glm Genetic Background: involves: 129S2/SvPas
MP:0005330	cardiomyopathy	"diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]	Show Allelic Composition: Nfatc1^tm1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MP:0005466	abnormal T helper 2 physiology	"anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0006047	aortic valve insufficiency	"the aortic valve does not close tightly enough to prevent leakage. " [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Tbx20^tm1Sev/Tbx20^tm1.1Sev,Nfatc1^tm1.1(cre)Bz/Nfatc1⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss
MP:0006049	semilunar valve insufficiency	"the semilunar valves do not close tightly enough to prevent leakage." [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nfatc1^tm1Glm/Nfatc1^tm1Glm Genetic Background: involves: 129S2/SvPas
MP:0006126	abnormal outflow tract development	"anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fos^tm1Wag/Fos^tm1Wag,Trp53^tm1Tyj/Trp53⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Nfatc1^tm1Glm/Nfatc1^tm1Glm,Tg(Tek-cre)1Ywa/0,Gt(ROSA)26Sor^tm1Sho/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * SJL Allelic Composition: Nfatc1^tm1Glm/Nfatc1^tm1Glm,H2afv^{Tg(Wnt1-cre)11Rth}/0,Gt(ROSA)26Sor^tm1Sho/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * CBA Allelic Composition: Nfatc1^tm1Glm/Nfatc1^tm1Glm Genetic Background: B6.129S2-Nfatc1^tm1Glm Allelic Composition: Nfatc1^tm1.1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MP:0008168	decreased B-1a cell number	"reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]	Show Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c
MP:0008193	abnormal marginal zone B cell physiology	"abnormal function of a CD23-negative, CD21-positive B cell of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c
MP:0008272	abnormal endochondral bone ossification	"anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]	Show Allelic Composition: Hdac3^tm1.2Eno/Hdac3^tm1.2Eno Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0008396	abnormal osteoclast differentiation	"atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hdac3^tm1.2Eno/Hdac3^tm1.2Eno Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Nfatc1^tm3Glm/Nfatc1^tm3Glm,Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0008495	decreased IgG1 level	"less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0008496	decreased IgG2a level	"less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Tg(Fcer2a-cre)5Mbu/0 Genetic Background: involves: C57BL/6 * CBA
MP:0008497	decreased IgG2b level	"less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0008498	decreased IgG3 level	"less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Tg(Fcer2a-cre)5Mbu/0 Genetic Background: involves: C57BL/6 * CBA
MP:0008500	increased IgG2a level	"greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0008559	abnormal interferon-gamma secretion	"anomaly in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0008660	increased interleukin-10 secretion	"increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]	Show Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Tg(Fcer2a-cre)5Mbu/0 Genetic Background: involves: C57BL/6 * CBA
MP:0008686	abnormal interleukin-2 secretion	"anomaly in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0008688	decreased interleukin-2 secretion	"reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]	Show Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Tg(Fcer2a-cre)5Mbu/0 Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Nfatc2^tm1Rao/Nfatc2^tm1Rao,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c
MP:0008700	decreased interleukin-4 secretion	"reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]	Show Allelic Composition: Vhl^tm1Lss/Vhl^tm1Lss,Tg(Pdx1-cre)89.1Dam/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0008782	increased B cell apoptosis	"increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c
MP:0009698	heart hemorrhage	"bleeding into the heart" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kdr^tm1Wag/Kdr^tm1Wag,Nfatc1^tm1.1(cre)Bz/Nfatc1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0010402	ventricular septal defect	"abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]	Show Allelic Composition: Nfatc1^tm1Glm/Nfatc1^tm1Glm Genetic Background: involves: 129S2/SvPas
MP:0010418	perimembraneous ventricular septal defect	"abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]	Show Allelic Composition: Nfatc1^tm1.1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MP:0010453	abnormal coronary vein morphology	"any structural anomaly of any of the veins that return blood from the heart muscles to the right atrium through the coronary sinus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc1^tm1.1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MP:0010482	abnormal aortic sinus morphology	"any structural anomaly of the spaces betwen the superior aspect of each of the three cusps of the aortic valve and the dilated portion of the wall of the ascending aorta, immediately above each cusp; the three sinuses include the posterior (non-coronary sinus), and the right and left aortic sinuses (from which the left and right coronary arteries arise)" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc1^tm1.1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MP:0010484	bicuspid aortic valve	"the presence of two cusps in the aortic valve instead of three" [http://emedicine.medscape.com]	Show Allelic Composition: Nfatc1^tm1.1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ Allelic Composition: Nfatc1^tm1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MP:0010593	thick aortic valve cusps	"an increase in the ratio of the aortic valve cusp thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc1^tm1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MP:0010594	thick aortic valve	"an increase in the ratio of the aortic valve wall thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc1^tm1.1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MP:0010595	abnormal aortic valve cusp morphology	"any structural anomaly of the three fibrous triangular components and associated flap of the aortic valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc1^tm1.1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MP:0010597	absent aortic valve cusps	"absence of the three fibrous triangular components and associated flaps of the aortic valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc1^tm1Glm/Nfatc1^tm1Glm Genetic Background: involves: 129S2/SvPas
MP:0010601	thick pulmonary valve	"an increase in the ratio of the pulmonary valve wall thickness to the pulmonary artery wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc1^tm1.1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ Allelic Composition: Nfatc1^tm1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MP:0010602	abnormal pulmonary valve cusp morphology	"any structural anomaly of the three fibrous triangular components and associated flap of the pulmonary valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc1^tm1.1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MP:0010604	absent pulmonary valve cusps	"absence of the three fibrous triangular components and associated flaps of the pulmonary valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc1^tm1Glm/Nfatc1^tm1Glm Genetic Background: involves: 129S2/SvPas
MP:0010656	thick myocardium	"increased thickness of the heart muscle layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc1^tm1.1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MP:0010875	increased bone volume	"increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hivep3^tm3Glm/Hivep3^tm3Glm,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Fos^tm1Wag/Fos^tm1Wag,Trp53^tm1Tyj/Trp53⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Nfatc1^tm1Glm/Nfatc1^tm1Glm Genetic Background: involves: 129S2/SvPas Allelic Composition: Kdr^tm1Wag/Kdr^tm1Wag,Nfatc1^tm1.1(cre)Bz/Nfatc1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Tbx20^tm1Sev/Tbx20^tm1.1Sev,Nfatc1^tm1.1(cre)Bz/Nfatc1⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss
MP:0011109	partial lethality throughout fetal growth and development	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Nfatc1^tm1.1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MP:0011648	thick heart valve cusps	"an increase in the heart cusp wall thickness" [MGI:csmith]	Show Allelic Composition: Nfatc1^tm1.1(cre)Bz/Nfatc1⁺,Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MP:0013241	embryo tissue necrosis	"morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]	Show Allelic Composition: Fos^tm1Wag/Fos^tm1Wag,Trp53^tm1Tyj/Trp53⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0030083	long upper incisors	"increased length or overgrowth of the upper set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]	Show Allelic Composition: Hdac3^tm1.2Eno/Hdac3^tm1.2Eno Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0030089	short lower incisors	"reduced length of the lower set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]	Show Allelic Composition: Hdac3^tm1.2Eno/Hdac3^tm1.2Eno Genetic Background: involves: 129S/SvEv * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000001175	Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*	/ reaction / complex
ENSMUSG00000021816	P48453 / Ppp3cb / protein phosphatase 3, catalytic subunit, beta isoform / P16298* / protein phosphatase 3 catalytic subunit beta*	/ reaction / complex
ENSMUSG00000028161	P63328 / Ppp3ca / protein phosphatase 3, catalytic subunit, alpha isoform / Q08209* / protein phosphatase 3 catalytic subunit alpha*	/ complex / reaction
ENSMUSG00000033953	Ppp3r1 / Q63810 / protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) / P63098* / protein phosphatase 3 regulatory subunit B, alpha*	/ complex / reaction

0 s.

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