ENSMUSG00000003847


Mus musculus

Features
Gene ID: ENSMUSG00000003847
  
Biological name :Nfat5
  
Synonyms : Nfat5 / nuclear factor of activated T cells 5 / Q9WV30
  
Possible biological names infered from orthology : O94916
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: D3
Gene start: 107293470
Gene end: 107379517
  
Corresponding Affymetrix probe sets: 10575160 (MoGene1.0st)   1426029_a_at (Mouse Genome 430 2.0 Array)   1438999_a_at (Mouse Genome 430 2.0 Array)   1439328_at (Mouse Genome 430 2.0 Array)   1439805_at (Mouse Genome 430 2.0 Array)   1448966_a_at (Mouse Genome 430 2.0 Array)   1451921_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119370
Ensembl peptide - ENSMUSP00000118130
Ensembl peptide - ENSMUSP00000122871
Ensembl peptide - ENSMUSP00000127784
Ensembl peptide - ENSMUSP00000075311
Ensembl peptide - ENSMUSP00000076653
Ensembl peptide - ENSMUSP00000115036
Ensembl peptide - ENSMUSP00000116094
Ensembl peptide - ENSMUSP00000116631
Ensembl peptide - ENSMUSP00000117554
NCBI entrez gene - 54446     See in Manteia.
MGI - MGI:1859333
RefSeq - XM_017312905
RefSeq - NM_018823
RefSeq - NM_133957
RefSeq - XM_006531191
RefSeq - XM_006531192
RefSeq - XM_006531193
RefSeq - XM_006531194
RefSeq - XM_006531195
RefSeq - XM_006531196
RefSeq - XM_006531197
RefSeq - XM_017312904
RefSeq - NM_001286260
RefSeq Peptide - NP_001273189
RefSeq Peptide - NP_061293
RefSeq Peptide - NP_598718
swissprot - D6RH40
swissprot - Q80TR0
swissprot - D6RH97
swissprot - A0A1U6URG8
swissprot - Q9WV30
swissprot - F6VCW7
swissprot - F6ZRF0
Ensembl - ENSMUSG00000003847
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfat5aENSDARG00000020872Danio rerio
 nfat5bENSDARG00000102556Danio rerio
 NFAT5ENSGALG00000039300Gallus gallus
 NFAT5ENSG00000102908Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nfatc3 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 / Q12968* / nuclear factor of activated T cells 3*ENSMUSG0000003190215
Nfatc1 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 / O95644* / nuclear factor of activated T cells 1*ENSMUSG0000003301614
Nfatc2 / Q60591 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 / Q13469* / nuclear factor of activated T cells 2*ENSMUSG0000002754413
Nfatc4 / Q8K120 / Nuclear factor of activated T-cells, cytoplasmic 4 / Q14934* / nuclear factor of activated T cells 4*ENSMUSG0000002341111


Protein motifs (from Interpro)
Interpro ID Name
 IPR002909  IPT domain
 IPR008366  Nuclear factor of activated T cells (NFAT)
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015646  Nuclear factor of activated T-cells 5
 IPR032397  Rel homology dimerisation domain
 IPR037059  Rel homology domain (RHD), DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production IDA
 biological_processGO:0006351 transcription, DNA-templated ISS
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006970 response to osmotic stress IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0070884 regulation of calcineurin-NFAT signaling cascade IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy/Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy,Smn1tm1Msd/Smn1+,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy/Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy,Smn1tm1Msd/Smn1+,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy/Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy,Smn1tm1Msd/Smn1+,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001784 abnormal fluid regulation "anomalous control of intracellular and/or extracellular fluid " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy/Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy,Smn1tm1Msd/Smn1+,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dgcr8Gt(XG058)Byg/Dgcr8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy/Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy,Smn1tm1Msd/Smn1+,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rad21tm2.1Kktk/Rad21tm2.1Kktk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy/Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy,Smn1tm1Msd/Smn1+,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB

 MP:0004056 abnormal myocardial compact layer morphology "malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy/Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy,Smn1tm1Msd/Smn1+,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB

 MP:0004194 abnormal kidney pelvis morphology "any structural anomaly of the funnel shaped proximal portion of the ureter that is formed by convergence of the major calices" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dgcr8Gt(XG058)Byg/Dgcr8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004970 kidney atrophy "wasting of the kidney due to injury or disease, resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy/Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy,Smn1tm1Msd/Smn1+,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Nfat5tm1Skc/Nfat5tm1Skc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Nek7tm1b(EUCOMM)Hmgu/Nek7tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nek7tm1b(EUCOMM)Hmgu/J

 MP:0011304 kidney papillary atrophy "acquired diminution of the size of the apex (tip) of a renal pyramid associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011332 abnormal kidney outer medulla morphology "any structural anomaly of the outer medullary region of the adult kidney containing the short Loops of Henle and collecting ducts" [MGI:csmith, PMID:20614633]
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Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011378 abnormal kidney outer medulla inner stripe morphology "any structural anomaly of the deep, centrally located portion of the renal outer medulla that is traversed by thin descending and thick ascending portions of the loops of Henle" [GO:0072057]
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Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011405 tubulointerstitial nephritis "diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease" [MGI:anna]
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Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0012007 abnormal chloride level "any change in the amount of chloride, the major extracellular anion in mammals; it plays roles in tissue fluid homeostasis and also helps maintain proper blood volume, blood pressure, and body fluid pH" [MGI:csmith]
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Allelic Composition: Dgcr8Gt(XG058)Byg/Dgcr8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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