Manteia - Molecule gene

ENSMUSG00000031902

Mus musculus

Features

Gene ID:	ENSMUSG00000031902

Biological name :	Nfatc3

Synonyms :	Nfatc3 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3

Possible biological names infered from orthology :	nuclear factor of activated T cells 3 / Q12968

Species:	Mus musculus

Chr. number:	8
Strand:	1
Band:	D3
Gene start:	106058840
Gene end:	106130537

Corresponding Affymetrix probe sets:	10574962 (MoGene1.0st) 1419976_s_at (Mouse Genome 430 2.0 Array) 1452497_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000148551 Ensembl peptide - ENSMUSP00000148556 Ensembl peptide - ENSMUSP00000104931 NCBI entrez gene - 18021 See in Manteia. MGI - MGI:103296 RefSeq - XM_006530753 RefSeq - XM_006530754 RefSeq - NM_010901 RefSeq Peptide - NP_035031 swissprot - Q3UZ64 swissprot - B5B2U2 swissprot - B5B2U1 Ensembl - ENSMUSG00000031902

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
nfatc3a	ENSDARG00000076297	Danio rerio
NFATC3	ENSGALG00000003396	Gallus gallus
NFATC3	ENSG00000072736	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Nfatc1 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 / O95644* / nuclear factor of activated T cells 1*	ENSMUSG00000033016	36
Nfatc4 / Q8K120 / Nuclear factor of activated T-cells, cytoplasmic 4 / Q14934* / nuclear factor of activated T cells 4*	ENSMUSG00000023411	35
Nfatc2 / Q60591 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 / Q13469* / nuclear factor of activated T cells 2*	ENSMUSG00000027544	32
Nfat5 / Q9WV30 / nuclear factor of activated T cells 5 / O94916*	ENSMUSG00000003847	22

Protein motifs (from Interpro)

Interpro ID	Name
IPR002909	IPT domain
IPR008366	Nuclear factor of activated T cells (NFAT)
IPR008967	p53-like transcription factor, DNA-binding
IPR011539	Rel homology domain (RHD), DNA-binding domain
IPR013783	Immunoglobulin-like fold
IPR014756	Immunoglobulin E-set
IPR032397	Rel homology dimerisation domain
IPR037059	Rel homology domain (RHD), DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	IEA
molecular_function	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IEA
molecular_function	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA

Pathways (from Reactome)

Pathway description

Calcineurin activates NFAT

FCERI mediated Ca+2 mobilization

CLEC7A (Dectin-1) induces NFAT activation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db Allelic Composition: Nfatc3^tm1Glm/Nfatc3^tm1Glm,Nfatc4^tm1Jmk/Nfatc4^tm1Jmk Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0000267	abnormal cardiac development	"aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]	Show Allelic Composition: Nfatc3^tm1Glm/Nfatc3^tm1Glm,Nfatc4^tm1Jmk/Nfatc4^tm1Jmk Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0000291	enlarged pericardium	"extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0000295	poorly developed ventricular trabeculae	"retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0000706	small thymus	"reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0000715	decreased thymocyte number	"fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Sell^tm3Tft/Sell^tm3Tft Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000717	abnormal lymphocyte number	"deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0000747	muscle weakness	"loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0000759	abnormal skeletal muscle morphology	"anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0000968	abnormal sensory neuron innervation	"defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db Allelic Composition: Nfatc2^tm1Glm/Nfatc2^tm1Glm,Nfatc3^tm1Glm/Nfatc3^tm1Glm,Nfatc4^tm1Grc/Nfatc4^tm1Grc Genetic Background: involves: 129S2/SvPas
MP:0001065	abnormal trigeminal nerve morphology	"malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]	Show Allelic Composition: Nfatc2^tm1Glm/Nfatc2^tm1Glm,Nfatc3^tm1Glm/Nfatc3^tm1Glm,Nfatc4^tm1Grc/Nfatc4^tm1Grc Genetic Background: involves: 129S2/SvPas
MP:0001303	abnormal lens morphology	"malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Nab2^{tm1b(EUCOMM)Hmgu}/Nab2^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Nab2^{tm1b(EUCOMM)Hmgu}/Ics
MP:0001364	decreased anxiety-related response	"when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0001488	increased startle reflex	"reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nab2^{tm1b(EUCOMM)Hmgu}/Nab2^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Nab2^{tm1b(EUCOMM)Hmgu}/Ics
MP:0001544	abnormal cardiovascular system physiology	"anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nfatc4^tm1Jmk/Nfatc4^tm1Jmk,Tg(Myh6-Ppp3ca)37Eno/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Nfatc3^tm1Glm/Nfatc3^tm1Glm,Nfatc4^tm1Jmk/Nfatc4^tm1Jmk Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0001614	abnormal vasculature	"anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0001625	cardiac hypertrophy	"an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db Allelic Composition: Nfatc2^tm1Glm/Nfatc2^tm1Glm,Nfatc3^tm1Glm/Nfatc3^tm1Glm,Nfatc4^tm1Grc/Nfatc4^tm1Grc Genetic Background: involves: 129S2/SvPas
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0001788	periorbital edema	"accumulation of an excessive amount of fluid in the area around the orbit " [MGI:tc, J:60896]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Sell^tm3Tft/Sell^tm3Tft Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001846	increased inflammatory response	"greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0001862	interstitial pneumonia	"disorder of the lower respiratory tract, primarily affecting the alveolar wall, but may also involve the small airways and blood vessels of the lung parencyma; this is usually inflammatory in nature" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nfatc3^tm1Grc/Nfatc3^tm1Grc,Tg(Lck-cre)I57Jxm/0 Genetic Background: involves: ICR
MP:0002145	abnormal T lymphocyte development	"atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sell^tm3Tft/Sell^tm3Tft Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Nfatc2^tm1Rao/Nfatc2^tm1Rao,Nfatc3^tm1Grc/Nfatc3^tm1Grc,Tg(Lck-cre)I57Jxm/0 Genetic Background: involves: ICR
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nfatc3^tm1.1Grc/Nfatc3^tm1.1Grc Genetic Background: involves: C57BL/6
MP:0002339	abnormal lymph node morphology	"anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0002407	abnormal double-negative T cell	"anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Nfatc2^tm1Rao/Nfatc2^tm1Rao,Nfatc3^tm1Grc/Nfatc3^tm1Grc,Tg(Lck-cre)I57Jxm/0 Genetic Background: involves: ICR
MP:0002557	abnormal social/conspecific interaction	"deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0002926	aganglionic megacolon	"extreme dilation of the colon due to defects in innervation from the ganglia, or absence of the ganglia of the myenteric plexus" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0003229	abnormal vitelline vasculature	"malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0003313	abnormal locomotor activation	"altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nfatc2^tm1Glm/Nfatc2^tm1Glm,Nfatc3^tm1Glm/Nfatc3^tm1Glm,Nfatc4^tm1Grc/Nfatc4^tm1Grc Genetic Background: involves: 129S2/SvPas
MP:0003884	decreased macrophage count	"fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]	Show Allelic Composition: Nab2^{tm1b(EUCOMM)Hmgu}/Nab2^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Nab2^{tm1b(EUCOMM)Hmgu}/Ics
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nfatc3^tm1Glm/Nfatc3^tm1Glm,Nfatc4^tm1Jmk/Nfatc4^tm1Jmk Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0004056	abnormal myocardial compact layer morphology	"malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Nfatc3^tm1Glm/Nfatc3^tm1Glm,Nfatc4^tm1Jmk/Nfatc4^tm1Jmk Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0004067	abnormal ventricular trabeculae morphology	"aberrant structure of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Nfatc3^tm1Glm/Nfatc3^tm1Glm,Nfatc4^tm1Jmk/Nfatc4^tm1Jmk Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0004144	hypotonia	"decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Nfatc2^tm1Glm/Nfatc2^tm1Glm,Nfatc3^tm1Glm/Nfatc3^tm1Glm,Nfatc4^tm1Grc/Nfatc4^tm1Grc Genetic Background: involves: 129S2/SvPas
MP:0004486	decreased response of heart to induced stress	"decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0004787	abnormal dorsal aorta morphology	"any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]	Show Allelic Composition: Nfatc3^tm1Glm/Nfatc3^tm1Glm,Nfatc4^tm1Jmk/Nfatc4^tm1Jmk Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0004937	dilated heart	"stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc3^tm1Glm/Nfatc3^tm1Glm,Nfatc4^tm1Jmk/Nfatc4^tm1Jmk Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0005014	increased B cell number	"greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0005015	increased T cell number	"greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0005090	increased double-negative T cells count	"greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db Allelic Composition: Nfatc3^tm1Grc/Nfatc3^tm1Grc,Tg(Lck-cre)I57Jxm/0 Genetic Background: involves: ICR
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0005251	blepharitis	"inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0005294	abnormal heart ventricle morphology	"structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nfatc3^tm1Glm/Nfatc3^tm1Glm,Nfatc4^tm1Jmk/Nfatc4^tm1Jmk Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0005329	abnormal cardiac muscle morphology	"anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Nfatc3^tm1Glm/Nfatc3^tm1Glm,Nfatc4^tm1Jmk/Nfatc4^tm1Jmk Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0006035	abnormal mitochondrial morphology	"anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nfatc3^tm1Glm/Nfatc3^tm1Glm,Nfatc4^tm1Jmk/Nfatc4^tm1Jmk Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0006261	annular pancreas	"an abnormal ring or collar of pancreatic tissue that encircles the duodenum" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:69854]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0006413	increased T cell apoptosis	"increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc3^tm1Grc/Nfatc3^tm1Grc,Tg(Lck-cre)I57Jxm/0 Genetic Background: involves: ICR Allelic Composition: Nfatc2^tm1Rao/Nfatc2^tm1Rao,Nfatc3^tm1Grc/Nfatc3^tm1Grc,Tg(Lck-cre)I57Jxm/0 Genetic Background: involves: ICR
MP:0008075	decreased CD4-positive T cell number	"reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc3^tm1Grc/Nfatc3^tm1Grc,Tg(Lck-cre)I57Jxm/0 Genetic Background: involves: ICR
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc3^tm1Grc/Nfatc3^tm1Grc,Tg(Lck-cre)I57Jxm/0 Genetic Background: involves: ICR
MP:0008101	lymph node hypoplasia	"underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc3^tm1Grc/Nfatc3^tm1Grc,Tg(Lck-cre)I57Jxm/0 Genetic Background: involves: ICR Allelic Composition: Nfatc3^tm1.1Grc/Nfatc3^tm1.1Grc Genetic Background: involves: C57BL/6
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc3^tm1.1Grc/Nfatc3^tm1.1Grc Genetic Background: involves: C57BL/6
MP:0008803	abnormal placental labyrinth vasculature morphology	"any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0009406	decreased skeletal muscle fiber number	"decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0009424	decreased extensor digitorum longus weight	"reduction in the weight of the penniform muscle of the lateral front part of the leg responsible for extension of the toes and dorsiflexion of the ankle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0009426	decreased soleus weight	"reduction in the weight of the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0009677	abnormal spinal cord dorsal column morphology	"any structural anomaly of the wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN-10:0940780577 "Goldberg, S, Clinical Neuroanatomy Made Ridiculously Simple, 3rd edition"]	Show Allelic Composition: Nfatc2^tm1Glm/Nfatc2^tm1Glm,Nfatc3^tm1Glm/Nfatc3^tm1Glm,Nfatc4^tm1Grc/Nfatc4^tm1Grc Genetic Background: involves: 129S2/SvPas
MP:0010053	decreased grip strength	"reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Nfatc2^tm1Glm/Nfatc2^tm1Glm,Nfatc3^tm1Glm/Nfatc3^tm1Glm,Nfatc4^tm1Grc/Nfatc4^tm1Grc Genetic Background: involves: 129S2/SvPas
MP:0010954	abnormal cellular respiration	"anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]	Show Allelic Composition: Nfatc3^tm1Glm/Nfatc3^tm1Glm,Nfatc4^tm1Jmk/Nfatc4^tm1Jmk Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Nfatc3^tm1Glm/Nfatc3^tm1Glm,Nfatc4^tm1Jmk/Nfatc4^tm1Jmk Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Nfatc3^tm1Glm/Nfatc3^tm1Glm,Nfatc4^tm1Jmk/Nfatc4^tm1Jmk,Tg(Myh6-NFATC4)#Eno/? Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Nab2^{tm1b(EUCOMM)Hmgu}/Nab2^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Nab2^{tm1b(EUCOMM)Hmgu}/Ics
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db Allelic Composition: Nfatc3^tm1.1Grc/Nfatc3^tm1.1Grc Genetic Background: involves: C57BL/6
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db
MP:0012253	abnormal intersomitic vessel morphology	"any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]	Show Allelic Composition: Mitf^mi-bws/Mitf^mi-bws Genetic Background: BKS.Cg-m+/+Lepr^db

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000001175	Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*	/ complex / reaction
ENSMUSG00000021816	P48453 / Ppp3cb / protein phosphatase 3, catalytic subunit, beta isoform / P16298* / protein phosphatase 3 catalytic subunit beta*	/ complex / reaction
ENSMUSG00000028161	P63328 / Ppp3ca / protein phosphatase 3, catalytic subunit, alpha isoform / Q08209* / protein phosphatase 3 catalytic subunit alpha*	/ reaction / complex
ENSMUSG00000033953	Ppp3r1 / Q63810 / protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) / P63098* / protein phosphatase 3 regulatory subunit B, alpha*	/ complex / reaction

1 s.

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