ENSMUSG00000027544


Mus musculus

Features
Gene ID: ENSMUSG00000027544
  
Biological name :Nfatc2
  
Synonyms : Nfatc2 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 / Q60591
  
Possible biological names infered from orthology : nuclear factor of activated T cells 2 / Q13469
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H3
Gene start: 168476410
Gene end: 168601657
  
Corresponding Affymetrix probe sets: 10489961 (MoGene1.0st)   1425901_at (Mouse Genome 430 2.0 Array)   1425990_a_at (Mouse Genome 430 2.0 Array)   1426031_a_at (Mouse Genome 430 2.0 Array)   1426032_at (Mouse Genome 430 2.0 Array)   1439205_at (Mouse Genome 430 2.0 Array)   1440426_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130875
Ensembl peptide - ENSMUSP00000074198
Ensembl peptide - ENSMUSP00000104812
Ensembl peptide - ENSMUSP00000118329
Ensembl peptide - ENSMUSP00000029057
NCBI entrez gene - 18019     See in Manteia.
MGI - MGI:102463
RefSeq - NM_001291172
RefSeq - NM_001037177
RefSeq - NM_001037178
RefSeq - NM_001136073
RefSeq - NM_001291168
RefSeq - NM_001291169
RefSeq - NM_001291170
RefSeq - NM_001291171
RefSeq - NM_001291173
RefSeq - NM_001291174
RefSeq - NM_001291175
RefSeq - NM_001291176
RefSeq - NM_001291177
RefSeq - NM_001291178
RefSeq - NM_001291179
RefSeq - NM_010899
RefSeq Peptide - NP_001278108
RefSeq Peptide - NP_001278104
RefSeq Peptide - NP_001278105
RefSeq Peptide - NP_001278106
RefSeq Peptide - NP_001278107
RefSeq Peptide - NP_035029
RefSeq Peptide - NP_001032254
RefSeq Peptide - NP_001032255
RefSeq Peptide - NP_001129545
RefSeq Peptide - NP_001278097
RefSeq Peptide - NP_001278098
RefSeq Peptide - NP_001278099
RefSeq Peptide - NP_001278100
RefSeq Peptide - NP_001278101
RefSeq Peptide - NP_001278102
RefSeq Peptide - NP_001278103
swissprot - Q60591
swissprot - Q8C443
swissprot - B5B2R5
swissprot - B5B2P7
swissprot - A2AQC8
Ensembl - ENSMUSG00000027544
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfatc2aENSDARG00000100927Danio rerio
 nfatc2bENSDARG00000079972Danio rerio
 NFATC2ENSGALG00000007963Gallus gallus
 NFATC2ENSG00000101096Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nfatc1 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 / O95644* / nuclear factor of activated T cells 1*ENSMUSG0000003301643
Nfatc3 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 / Q12968* / nuclear factor of activated T cells 3*ENSMUSG0000003190238
Nfatc4 / Q8K120 / Nuclear factor of activated T-cells, cytoplasmic 4 / Q14934* / nuclear factor of activated T cells 4*ENSMUSG0000002341132
Nfat5 / Q9WV30 / nuclear factor of activated T cells 5 / O94916*ENSMUSG0000000384722


Protein motifs (from Interpro)
Interpro ID Name
 IPR002909  IPT domain
 IPR008366  Nuclear factor of activated T cells (NFAT)
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR032397  Rel homology dimerisation domain
 IPR037059  Rel homology domain (RHD), DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001816 cytokine production IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0014904 myotube cell development IMP
 biological_processGO:0016477 cell migration ISS
 biological_processGO:0030890 positive regulation of B cell proliferation ISO
 biological_processGO:0033173 calcineurin-NFAT signaling cascade IGI
 biological_processGO:0042493 response to drug ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0050853 B cell receptor signaling pathway ISO
 biological_processGO:1901741 positive regulation of myoblast fusion IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IPI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0044798 nuclear transcription factor complex IDA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0019902 phosphatase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA


Pathways (from Reactome)
Pathway description
Calcineurin activates NFAT
FCERI mediated Ca+2 mobilization
CLEC7A (Dectin-1) induces NFAT activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd

 MP:0000708 thymus hyperplasia "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn2atm1Cjs/Cdkn2a+,Tgfb2tm1Doe/Tgfb2tm1Doe
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0001824 abnormal thymic involution "premature or late decline in thymic function normally associated with advancing age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gfra2tm1Msa/Gfra2tm1Msa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

 MP:0001862 interstitial pneumonia "disorder of the lower respiratory tract, primarily affecting the alveolar wall, but may also involve the small airways and blood vessels of the lung parencyma; this is usually inflammatory in nature" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfatc2tm1Rao/Nfatc2tm1Rao,Nfatc3tm1Grc/Nfatc3tm1Grc,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: ICR

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd

 MP:0002344 abnormal lymph node B cell domain "anomaly in the lymph node cortex in which B lymphocytes reside" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002407 abnormal double-negative T cell "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nfatc2tm1Rao/Nfatc2tm1Rao,Nfatc3tm1Grc/Nfatc3tm1Grc,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: ICR

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il4tm1Rao/Il4tm1Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gfra2tm1Msa/Gfra2tm1Msa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gfra2tm1Msa/Gfra2tm1Msa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004144 hypotonia "decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0004469 abnormal zygomatic arch morphology "any structural anomaly of the bony arch in vertebrates that extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

 MP:0005251 blepharitis "inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfatc2tm1Rao/Nfatc2tm1Rao,Nfatc3tm1Grc/Nfatc3tm1Grc,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: ICR

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Il4tm1Rao/Il4tm1Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Il4tm1Rao/Il4tm1Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Il4tm1Rao/Il4tm1Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008702 increased interleukin-5 secretion "increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd

 MP:0009677 abnormal spinal cord dorsal column morphology "any structural anomaly of the wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN-10:0940780577 "Goldberg, S, Clinical Neuroanatomy Made Ridiculously Simple, 3rd edition"]
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Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / reaction / complex
 ENSMUSG00000021816 P48453 / Ppp3cb / protein phosphatase 3, catalytic subunit, beta isoform / P16298* / protein phosphatase 3 catalytic subunit beta*  / complex / reaction
 ENSMUSG00000028161 P63328 / Ppp3ca / protein phosphatase 3, catalytic subunit, alpha isoform / Q08209* / protein phosphatase 3 catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000033953 Ppp3r1 / Q63810 / protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) / P63098* / protein phosphatase 3 regulatory subunit B, alpha*  / complex / reaction






 

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