ENSMUSG00000021816


Mus musculus

Features
Gene ID: ENSMUSG00000021816
  
Biological name :Ppp3cb
  
Synonyms : P48453 / Ppp3cb / protein phosphatase 3, catalytic subunit, beta isoform
  
Possible biological names infered from orthology : P16298 / protein phosphatase 3 catalytic subunit beta
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: A3
Gene start: 20499364
Gene end: 20546573
  
Corresponding Affymetrix probe sets: 10417895 (MoGene1.0st)   1427468_at (Mouse Genome 430 2.0 Array)   1428473_at (Mouse Genome 430 2.0 Array)   1428474_at (Mouse Genome 430 2.0 Array)   1433835_at (Mouse Genome 430 2.0 Array)   1446149_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125722
Ensembl peptide - ENSMUSP00000022355
Ensembl peptide - ENSMUSP00000125582
Ensembl peptide - ENSMUSP00000125630
NCBI entrez gene - 19056     See in Manteia.
MGI - MGI:107163
RefSeq - XM_017315921
RefSeq - NM_001310426
RefSeq - NM_001310427
RefSeq - NM_008914
RefSeq - XM_006518707
RefSeq - XM_006518708
RefSeq - XM_006518711
RefSeq Peptide - NP_032940
RefSeq Peptide - NP_001297356
RefSeq Peptide - NP_001297355
swissprot - E0CZ78
swissprot - P48453
swissprot - G3X8U7
swissprot - E9Q6P2
Ensembl - ENSMUSG00000021816
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PPP3CBENSGALG00000005243Gallus gallus
 P16298ENSG00000107758Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P63328 / Ppp3ca / protein phosphatase 3, catalytic subunit, alpha isoform / Q08209* / protein phosphatase 3 catalytic subunit alpha*ENSMUSG0000002816181
P48455 / Ppp3cc / protein phosphatase 3, catalytic subunit, gamma isoform / P48454* / protein phosphatase 3 catalytic subunit gamma*ENSMUSG0000002209274


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR006186  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001915 negative regulation of T cell mediated cytotoxicity IMP
 biological_processGO:0001946 lymphangiogenesis IGI
 biological_processGO:0006468 protein phosphorylation IMP
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0017156 calcium ion regulated exocytosis IDA
 biological_processGO:0030217 T cell differentiation IMP
 biological_processGO:0031987 locomotion involved in locomotory behavior IMP
 biological_processGO:0033173 calcineurin-NFAT signaling cascade IEA
 biological_processGO:0034097 response to cytokine IMP
 biological_processGO:0035176 social behavior IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
 biological_processGO:0043029 T cell homeostasis IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050796 regulation of insulin secretion ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005955 calcineurin complex IEA
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0030315 T-tubule IDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IDA
 molecular_functionGO:0004723 calcium-dependent protein serine/threonine phosphatase activity TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding ISO
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030346 protein phosphatase 2B binding IEA
 molecular_functionGO:0033192 calmodulin-dependent protein phosphatase activity IMP
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Calcineurin activates NFAT
FCERI mediated Ca+2 mobilization
Ca2+ pathway
CLEC7A (Dectin-1) induces NFAT activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Atp2a2tm1Ges/Atp2a2+,Tg(Myh6/tetO-Tnnc1*L48Q)2Jmol/0,Tg(Myh6-tTA)55Rbns/0
Genetic Background: involves: 129X1/SvJ * FVB

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppp3cbM1Btlr/Ppp3cbM1Btlr
Genetic Background: C57BL/6J-Ppp3cbM1Btlr

Allelic Composition: Ppp3cbM1Btlr/Ppp3cb+
Genetic Background: C57BL/6J-Ppp3cbM1Btlr

Allelic Composition: Ppp3cbm2Btlr/Ppp3cbm2Btlr
Genetic Background: C57BL/6J-Ppp3cbm2Btlr

Allelic Composition: Ppp3cbm2Btlr/Ppp3cb+
Genetic Background: C57BL/6J-Ppp3cbm2Btlr

 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp2a2tm1Ges/Atp2a2+,Tg(Myh6/tetO-Tnnc1*L48Q)2Jmol/0,Tg(Myh6-tTA)55Rbns/0
Genetic Background: involves: 129X1/SvJ * FVB

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ppp3cbM1Btlr/Ppp3cbM1Btlr
Genetic Background: C57BL/6J-Ppp3cbM1Btlr

Allelic Composition: Ppp3cbM1Btlr/Ppp3cb+
Genetic Background: C57BL/6J-Ppp3cbM1Btlr

Allelic Composition: Ppp3cbm2Btlr/Ppp3cbm2Btlr
Genetic Background: C57BL/6J-Ppp3cbm2Btlr

Allelic Composition: Ppp3cbm2Btlr/Ppp3cb+
Genetic Background: C57BL/6J-Ppp3cbm2Btlr

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac

 MP:0009405 increased skeletal muscle fiber number "increased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac

 MP:0010579 increased heart left ventricle size "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp2a2tm1Ges/Atp2a2+,Tg(Myh6/tetO-Tnnc1*L48Q)2Jmol/0,Tg(Myh6-tTA)55Rbns/0
Genetic Background: involves: 129X1/SvJ * FVB

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp2a2tm1Ges/Atp2a2+,Tg(Myh6/tetO-Tnnc1*L48Q)2Jmol/0,Tg(Myh6-tTA)55Rbns/0
Genetic Background: involves: 129X1/SvJ * FVB

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
Show

Allelic Composition: Ppp3cbM1Btlr/Ppp3cbM1Btlr
Genetic Background: C57BL/6J-Ppp3cbM1Btlr

Allelic Composition: Ppp3cbM1Btlr/Ppp3cb+
Genetic Background: C57BL/6J-Ppp3cbM1Btlr

Allelic Composition: Ppp3cbm2Btlr/Ppp3cbm2Btlr
Genetic Background: C57BL/6J-Ppp3cbm2Btlr

 MP:0010839 decreased CD8-positive, alpha-beta memory T cell number "decreased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000909, GO_REF:0000031, GOC:tfm, PMID:20146720]
Show

Allelic Composition: Map3k8M4Btlr/Map3k8+
Genetic Background: C57BL/6J-Map3k8M4Btlr

Allelic Composition: Ppp3cbM3Btlr/Ppp3cb+
Genetic Background: C57BL/6J-Ppp3cbM3Btlr

Allelic Composition: Ppp3cbM4Btlr/Ppp3cbM4Btlr
Genetic Background: C57BL/6J-Ppp3cbM4Btlr

Allelic Composition: Ppp3cbM4Btlr/Ppp3cb+
Genetic Background: C57BL/6J-Ppp3cbM4Btlr

 MP:0010841 increased central memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000904, GO_REF:0000031, GOC:add, GOC:pam]
Show

Allelic Composition: Map3k8M4Btlr/Map3k8+
Genetic Background: C57BL/6J-Map3k8M4Btlr

Allelic Composition: Ppp3cbM3Btlr/Ppp3cb+
Genetic Background: C57BL/6J-Ppp3cbM3Btlr

 MP:0010847 increased central memory CD8 positive, alpha-beta T cell number "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000907, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720]
Show

Allelic Composition: Map3k8M4Btlr/Map3k8+
Genetic Background: C57BL/6J-Map3k8M4Btlr

Allelic Composition: Ppp3cbM4Btlr/Ppp3cbM4Btlr
Genetic Background: C57BL/6J-Ppp3cbM4Btlr

Allelic Composition: Ppp3cbM4Btlr/Ppp3cb+
Genetic Background: C57BL/6J-Ppp3cbM4Btlr

 MP:0011822 increased CD8-positive, alpha-beta memory T cell proliferation "increase in the ability of the a CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high, to undergo expansion by cell division" [CL:0000909]
Show

Allelic Composition: Ppp3cbM1Btlr/Ppp3cbM1Btlr
Genetic Background: C57BL/6J-Ppp3cbM1Btlr

Allelic Composition: Ppp3cbM1Btlr/Ppp3cb+
Genetic Background: C57BL/6J-Ppp3cbM1Btlr

Allelic Composition: Ppp3cbm2Btlr/Ppp3cbm2Btlr
Genetic Background: C57BL/6J-Ppp3cbm2Btlr

Allelic Composition: Ppp3cbm2Btlr/Ppp3cb+
Genetic Background: C57BL/6J-Ppp3cbm2Btlr

 MP:0013435 decreased CD8-positive, naive alpha-beta T cell number "reduction in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran]
Show

Allelic Composition: Map3k8M4Btlr/Map3k8+
Genetic Background: C57BL/6J-Map3k8M4Btlr

 MP:0020001 decreased response to antigen "decreased or weak immune response after exposure to an antigen" [GOC:NV]
Show

Allelic Composition: Ppp3cbm2Btlr/Ppp3cbm2Btlr
Genetic Background: C57BL/6J-Ppp3cbm2Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / complex / reaction
 ENSMUSG00000027544 Nfatc2 / Q60591 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 / Q13469* / nuclear factor of activated T cells 2*  / complex / reaction
 ENSMUSG00000033016 Nfatc1 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 / O95644* / nuclear factor of activated T cells 1*  / complex / reaction
 ENSMUSG00000033953 Ppp3r1 / Q63810 / protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) / P63098* / protein phosphatase 3 regulatory subunit B, alpha*  / complex
 ENSMUSG00000031902 Nfatc3 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 / Q12968* / nuclear factor of activated T cells 3*  / reaction / complex
 ENSMUSG00000021057 Akap5 / D3YVF0 / A-kinase anchor protein 5 / P24588* / A-kinase anchoring protein 5*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr