ENSG00000107758


Homo sapiens

Features
Gene ID: ENSG00000107758
  
Biological name :PPP3CB
  
Synonyms : P16298 / PPP3CB / protein phosphatase 3 catalytic subunit beta
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q22.2
Gene start: 73436428
Gene end: 73496024
  
Corresponding Affymetrix probe sets: 202432_at (Human Genome U133 Plus 2.0 Array)   209817_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000378305
Ensembl peptide - ENSP00000343147
Ensembl peptide - ENSP00000353881
Ensembl peptide - ENSP00000378306
Ensembl peptide - ENSP00000398022
NCBI entrez gene - 5532     See in Manteia.
OMIM - 114106
RefSeq - XM_017016379
RefSeq - NM_001142353
RefSeq - NM_001142354
RefSeq - NM_001289968
RefSeq - NM_001289969
RefSeq - NM_021132
RefSeq - XM_005269944
RefSeq Peptide - NP_001276897
RefSeq Peptide - NP_001276898
RefSeq Peptide - NP_066955
RefSeq Peptide - NP_001135825
RefSeq Peptide - NP_001135826
swissprot - Q5F2G0
swissprot - P16298
swissprot - Q5F2F8
Ensembl - ENSG00000107758
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PPP3CBENSGALG00000005243Gallus gallus
 P48453ENSMUSG00000021816Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PPP3CA / Q08209 / protein phosphatase 3 catalytic subunit alphaENSG0000013881482
P48454 / PPP3CC / protein phosphatase 3 catalytic subunit gammaENSG0000012091078


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR006186  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001915 negative regulation of T cell mediated cytotoxicity IEA
 biological_processGO:0001946 lymphangiogenesis IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway TAS
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007612 learning TAS
 biological_processGO:0007613 memory TAS
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0016311 dephosphorylation TAS
 biological_processGO:0017156 calcium ion regulated exocytosis IEA
 biological_processGO:0030217 T cell differentiation IEA
 biological_processGO:0031987 locomotion involved in locomotory behavior IEA
 biological_processGO:0033173 calcineurin-NFAT signaling cascade IDA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0035176 social behavior IEP
 biological_processGO:0035690 cellular response to drug IDA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0042098 T cell proliferation NAS
 biological_processGO:0042110 T cell activation TAS
 biological_processGO:0043029 T cell homeostasis IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated NAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048167 regulation of synaptic plasticity TAS
 biological_processGO:0048675 axon extension TAS
 biological_processGO:0050796 regulation of insulin secretion ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005955 calcineurin complex IDA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0030315 T-tubule IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding NAS
 molecular_functionGO:0008144 drug binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IDA
 molecular_functionGO:0030346 protein phosphatase 2B binding IDA
 molecular_functionGO:0033192 calmodulin-dependent protein phosphatase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046983 protein dimerization activity IPI


Pathways (from Reactome)
Pathway description
DARPP-32 events
Calcineurin activates NFAT
FCERI mediated Ca+2 mobilization
Ca2+ pathway
CLEC7A (Dectin-1) induces NFAT activation
ROBO receptors bind AKAP5


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000131196 NFATC1 / O95644 / nuclear factor of activated T cells 1  / reaction / complex
 ENSG00000221823 P63098 / PPP3R1 / protein phosphatase 3 regulatory subunit B, alpha  / complex
 ENSG00000072736 NFATC3 / Q12968 / nuclear factor of activated T cells 3  / complex / reaction
 ENSG00000185008 ROBO2 / Q9HCK4 / roundabout guidance receptor 2  / reaction / complex
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / complex / reaction
 ENSG00000101096 NFATC2 / Q13469 / nuclear factor of activated T cells 2  / complex / reaction
 ENSG00000179841 AKAP5 / P24588 / A-kinase anchoring protein 5  / complex / reaction






 

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