ENSG00000120910


Homo sapiens

Features
Gene ID: ENSG00000120910
  
Biological name :PPP3CC
  
Synonyms : P48454 / PPP3CC / protein phosphatase 3 catalytic subunit gamma
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p21.3
Gene start: 22440819
Gene end: 22541142
  
Corresponding Affymetrix probe sets: 207000_s_at (Human Genome U133 Plus 2.0 Array)   213950_s_at (Human Genome U133 Plus 2.0 Array)   32540_at (Human Genome U133 Plus 2.0 Array)   32541_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000430555
Ensembl peptide - ENSP00000429379
Ensembl peptide - ENSP00000430783
Ensembl peptide - ENSP00000240139
Ensembl peptide - ENSP00000289963
Ensembl peptide - ENSP00000380878
Ensembl peptide - ENSP00000428358
Ensembl peptide - ENSP00000428390
NCBI entrez gene - 5533     See in Manteia.
OMIM - 114107
RefSeq - XM_017013611
RefSeq - NM_001243974
RefSeq - NM_001243975
RefSeq - NM_005605
RefSeq - XM_017013610
RefSeq Peptide - NP_005596
RefSeq Peptide - NP_001230903
RefSeq Peptide - NP_001230904
swissprot - H0YB04
swissprot - H0YC26
swissprot - G3V111
swissprot - H0YB02
swissprot - P48454
swissprot - E5RJH4
Ensembl - ENSG00000120910
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp3ccaENSDARG00000014962Danio rerio
 ppp3ccbENSDARG00000057456Danio rerio
 P48455ENSMUSG00000022092Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P16298 / PPP3CB / protein phosphatase 3 catalytic subunit betaENSG0000010775879
PPP3CA / Q08209 / protein phosphatase 3 catalytic subunit alphaENSG0000013881478


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR006186  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0033173 calcineurin-NFAT signaling cascade IDA
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0033192 calmodulin-dependent protein phosphatase activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of BAD and translocation to mitochondria
DARPP-32 events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000002330 BAD / Q92934 / BCL2 associated agonist of cell death  / reaction
 ENSG00000221823 P63098 / PPP3R1 / protein phosphatase 3 regulatory subunit B, alpha  / complex
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr