ENSMUSG00000022092


Mus musculus

Features
Gene ID: ENSMUSG00000022092
  
Biological name :Ppp3cc
  
Synonyms : P48455 / Ppp3cc / protein phosphatase 3, catalytic subunit, gamma isoform
  
Possible biological names infered from orthology : P48454 / protein phosphatase 3 catalytic subunit gamma
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D2
Gene start: 70217865
Gene end: 70289471
  
Corresponding Affymetrix probe sets: 10421293 (MoGene1.0st)   1420743_a_at (Mouse Genome 430 2.0 Array)   1430025_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077532
Ensembl peptide - ENSMUSP00000153725
NCBI entrez gene - 19057     See in Manteia.
MGI - MGI:107162
RefSeq - XM_017315925
RefSeq - NM_001304991
RefSeq - NM_001304992
RefSeq - NM_008915
RefSeq - XM_006518714
RefSeq - XM_006518715
RefSeq - XM_017315922
RefSeq - XM_017315923
RefSeq - XM_017315924
RefSeq Peptide - NP_001291921
RefSeq Peptide - NP_032941
RefSeq Peptide - NP_001291920
swissprot - P48455
swissprot - Q3V074
Ensembl - ENSMUSG00000022092
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp3ccaENSDARG00000014962Danio rerio
 ppp3ccbENSDARG00000057456Danio rerio
 P48454ENSG00000120910Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P48453 / Ppp3cb / protein phosphatase 3, catalytic subunit, beta isoform / P16298* / protein phosphatase 3 catalytic subunit beta*ENSMUSG0000002181676
P63328 / Ppp3ca / protein phosphatase 3, catalytic subunit, alpha isoform / Q08209* / protein phosphatase 3 catalytic subunit alpha*ENSMUSG0000002816175


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR006186  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0033173 calcineurin-NFAT signaling cascade IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0033192 calmodulin-dependent protein phosphatase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of BAD and translocation to mitochondria


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0009282 reduced hyperactivated sperm motility "loss or reduction of the hyperactivated type of sperm mobility, impairing the ability of sperm to reach the site of fertilization and to penetrate the oocyte vestments; a block in hyperactivated motility may also impair the ability of a sperm to fertilize an oocyte in vitro" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0009831 abnormal sperm midpiece morphology "any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]
Show

Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033953 Ppp3r1 / Q63810 / protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) / P63098* / protein phosphatase 3 regulatory subunit B, alpha*  / complex
 ENSMUSG00000024959 Bad / Q61337 / Bcl2-associated agonist of cell death / Q92934*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr