ENSMUSG00000028161


Mus musculus

Features
Gene ID: ENSMUSG00000028161
  
Biological name :Ppp3ca
  
Synonyms : P63328 / Ppp3ca / protein phosphatase 3, catalytic subunit, alpha isoform
  
Possible biological names infered from orthology : protein phosphatase 3 catalytic subunit alpha / Q08209
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G3
Gene start: 136670124
Gene end: 136937727
  
Corresponding Affymetrix probe sets: 10496338 (MoGene1.0st)   1426401_at (Mouse Genome 430 2.0 Array)   1438478_a_at (Mouse Genome 430 2.0 Array)   1452056_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053101
Ensembl peptide - ENSMUSP00000071040
NCBI entrez gene - 19055     See in Manteia.
MGI - MGI:107164
RefSeq - XM_017319493
RefSeq - NM_001293622
RefSeq - NM_008913
RefSeq - XM_017319492
RefSeq Peptide - NP_032939
RefSeq Peptide - NP_001280551
swissprot - P63328
swissprot - B2RRX2
Ensembl - ENSMUSG00000028161
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp3caENSDARG00000004988Danio rerio
 ppp3cbENSDARG00000025106Danio rerio
 PPP3CAENSGALG00000039498Gallus gallus
 PPP3CAENSG00000138814Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P48453 / Ppp3cb / protein phosphatase 3, catalytic subunit, beta isoform / P16298* / protein phosphatase 3 catalytic subunit beta*ENSMUSG0000002181682
P48455 / Ppp3cc / protein phosphatase 3, catalytic subunit, gamma isoform / P48454* / protein phosphatase 3 catalytic subunit gamma*ENSMUSG0000002209274


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR006186  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IMP
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0006470 protein dephosphorylation IDA
 biological_processGO:0006606 protein import into nucleus IDA
 biological_processGO:0006816 calcium ion transport IMP
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IGI
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010629 negative regulation of gene expression IDA
 biological_processGO:0014883 transition between fast and slow fiber IDA
 biological_processGO:0014898 cardiac muscle hypertrophy in response to stress IGI
 biological_processGO:0016311 dephosphorylation IDA
 biological_processGO:0019722 calcium-mediated signaling IGI
 biological_processGO:0033173 calcineurin-NFAT signaling cascade ISO
 biological_processGO:0033555 multicellular organismal response to stress IDA
 biological_processGO:0035562 negative regulation of chromatin binding IMP
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0045807 positive regulation of endocytosis IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0048741 skeletal muscle fiber development IMP
 biological_processGO:0050774 negative regulation of dendrite morphogenesis IMP
 biological_processGO:0050804 modulation of chemical synaptic transmission IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0051592 response to calcium ion ISS
 biological_processGO:0060079 excitatory postsynaptic potential IGI
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress IDA
 biological_processGO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA IDA
 biological_processGO:1905205 positive regulation of connective tissue replacement IGI
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005955 calcineurin complex ISO
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0043197 dendritic spine IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IDA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0004723 calcium-dependent protein serine/threonine phosphatase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding ISO
 molecular_functionGO:0008144 drug binding ISO
 molecular_functionGO:0016018 cyclosporin A binding ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0033192 calmodulin-dependent protein phosphatase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Calcineurin activates NFAT
FCERI mediated Ca+2 mobilization
Ca2+ pathway
CLEC7A (Dectin-1) induces NFAT activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nat2tm1Esim/Nat2+
Genetic Background: A.129P2-Nat2tm1Esim

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Nat2tm1Esim/Nat2+
Genetic Background: A.129P2-Nat2tm1Esim

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nat2tm1Esim/Nat2+
Genetic Background: A.129P2-Nat2tm1Esim

 MP:0002761 abnormal hippocampal mossy fiber morphology "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]
Show

Allelic Composition: Msx2tm1Rem/Msx2tm1Rem,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002987 abnormal urine osmolarity "changes in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
Show

Allelic Composition: Nat2tm1Esim/Nat2+
Genetic Background: A.129P2-Nat2tm1Esim

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
Show

Allelic Composition: Nat2tm1Esim/Nat2+
Genetic Background: A.129P2-Nat2tm1Esim

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Nat2tm1Esim/Nat2+
Genetic Background: A.129P2-Nat2tm1Esim

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nat2tm1Esim/Nat2+
Genetic Background: A.129P2-Nat2tm1Esim

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nat2tm1Esim/Nat2+
Genetic Background: A.129P2-Nat2tm1Esim

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009401 increased skeletal muscle fiber diameter "increased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nat2tm1Esim/Nat2+
Genetic Background: A.129P2-Nat2tm1Esim

 MP:0009406 decreased skeletal muscle fiber number "decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nat2tm1Esim/Nat2+
Genetic Background: A.129P2-Nat2tm1Esim

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nat2tm1Esim/Nat2+
Genetic Background: A.129P2-Nat2tm1Esim

 MP:0011471 decreased urine creatinine level "a reduced amount of creatinine in the urine compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Nat2tm1Esim/Nat2+
Genetic Background: A.129P2-Nat2tm1Esim

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / complex / reaction
 ENSMUSG00000033016 Nfatc1 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 / O95644* / nuclear factor of activated T cells 1*  / complex / reaction
 ENSMUSG00000027544 Nfatc2 / Q60591 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 / Q13469* / nuclear factor of activated T cells 2*  / complex / reaction
 ENSMUSG00000031902 Nfatc3 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 / Q12968* / nuclear factor of activated T cells 3*  / reaction / complex
 ENSMUSG00000033953 Ppp3r1 / Q63810 / protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) / P63098* / protein phosphatase 3 regulatory subunit B, alpha*  / complex






 

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