ENSDARG00000004988


Danio rerio

Features
Gene ID: ENSDARG00000004988
  
Biological name :ppp3ca
  
Synonyms : ppp3ca / protein phosphatase 3, catalytic subunit, alpha isozyme
  
Possible biological names infered from orthology : P63328 / protein phosphatase 3 catalytic subunit alpha / protein phosphatase 3, catalytic subunit, alpha isoform / Q08209
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 28958471
Gene end: 29075815
  
Corresponding Affymetrix probe sets: Dr.22751.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000024334
Ensembl peptide - ENSDARP00000123171
NCBI entrez gene - 794574     See in Manteia.
RefSeq - NM_001198550
RefSeq Peptide - NP_001185479
swissprot - F1QD93
swissprot - E9QD09
ZFIN ID - ZDB-GENE-091113-24
Ensembl - ENSDARG00000004988
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PPP3CAENSGALG00000039498Gallus gallus
 PPP3CAENSG00000138814Homo sapiens
 P63328ENSMUSG00000028161Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ppp3cb / protein phosphatase 3, catalytic subunit, beta isozyme / Q08209* / P63328* / PPP3CA* / protein phosphatase 3 catalytic subunit alpha* / protein phosphatase 3, catalytic subunit, al...ENSDARG0000002510692
ppp3ccb / protein phosphatase 3, catalytic subunit, gamma isozyme, b / P48455* / PPP3CC* / P48454* / protein phosphatase 3 catalytic subunit gamma* / protein phosphatase 3, catalytic subuni...ENSDARG0000005745676
ppp3cca / protein phosphatase 3, catalytic subunit, gamma isozyme, a / P48455* / PPP3CC* / P48454* / protein phosphatase 3 catalytic subunit gamma* / protein phosphatase 3, catalytic subuni...ENSDARG0000001496275


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR006186  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Calcineurin activates NFAT
FCERI mediated Ca+2 mobilization
Ca2+ pathway
CLEC7A (Dectin-1) induces NFAT activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000076297 nfatc3a / nuclear factor of activated T cells 3a / Q12968* / NFATC3* / nuclear factor of activated T cells 3* / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3*  / reaction / complex
 ENSDARG00000069360 ppp3r1b / protein phosphatase 3 (formerly 2B), regulatory s1ubunit B, alpha isoform, b / PPP3R1* / P63098* / Q63810* / protein phosphatase 3 regulatory subunit B, alpha* / protein phosphata...  / complex
 ENSDARG00000100825 calm2a / calm2b / calm3a / Q6PI52 / calmodulin 2a (phosphorylase kinase, delta)  / complex / reaction
 ENSDARG00000100927 nfatc2a / nuclear factor of activated T cells 2a / NFATC2* / Q13469* / Q60591* / nuclear factor of activated T cells 2* / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2*  / reaction / complex
 ENSDARG00000079972 nfatc2b / nuclear factor of activated T cells 2b / NFATC2* / Q13469* / nuclear factor of activated T cells 2*  / reaction / complex






 

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