ENSDARG00000069360


Danio rerio

Features
Gene ID: ENSDARG00000069360
  
Biological name :ppp3r1b
  
Synonyms : ppp3r1b / protein phosphatase 3 (formerly 2B), regulatory s1ubunit B, alpha isoform, b
  
Possible biological names infered from orthology : P63098 / PPP3R1 / protein phosphatase 3 regulatory subunit B, alpha / protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) / Q63810
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 51557789
Gene end: 51591436
  
Corresponding Affymetrix probe sets: Dr.19079.1.S1_at (Zebrafish Array)   Dr.25627.1.A1_at (Zebrafish Array)   NM_001004553_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000091642
NCBI entrez gene - 447814     See in Manteia.
RefSeq - NM_001004553
RefSeq Peptide - NP_001004553
swissprot - Q66HZ0
ZFIN ID - ZDB-GENE-040912-18
Ensembl - ENSDARG00000069360
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P63098ENSG00000221823Homo sapiens
 Ppp3r1ENSMUSG00000033953Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ppp3r1a / protein phosphatase 3, regulatory subunit B, alpha a / Q96LZ3* / PPP3R2* / Q63811* / AC017083.3* / protein phosphatase 3 regulatory subunit B, beta* / protein phosphatase 3, regul...ENSDARG0000009265999
chp1 / calcineurin-like EF-hand protein 1 / P61022* / Q99653* / Calcineurin B homologous protein 1 *ENSDARG0000005285939
chp2 / calcineurin-like EF-hand protein 2 / O43745* / Q9D869* / Calcineurin B homologous protein 2 *ENSDARG0000002578836
tesca / tescalcin a / TESC* / Tescl* / Q9JKL5* / Q96BS2* / tescalcin*ENSDARG0000002834629
tescb / tescalcin b / TESC* / Tescl* / Q9JKL5* / Q96BS2* / tescalcin*ENSDARG0000003083928


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of BAD and translocation to mitochondria
Calcineurin activates NFAT
FCERI mediated Ca+2 mobilization
Ca2+ pathway
CLEC7A (Dectin-1) induces NFAT activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000004988 ppp3ca / protein phosphatase 3, catalytic subunit, alpha isozyme / P63328* / Q08209* / protein phosphatase 3 catalytic subunit alpha* / protein phosphatase 3, catalytic subunit, alpha isoform*  / complex
 ENSDARG00000025106 ppp3cb / protein phosphatase 3, catalytic subunit, beta isozyme / Q08209* / P63328* / PPP3CA* / protein phosphatase 3 catalytic subunit alpha* / protein phosphatase 3, catalytic subunit, al...  / complex
 ENSDARG00000057456 ppp3ccb / protein phosphatase 3, catalytic subunit, gamma isozyme, b / P48455* / PPP3CC* / P48454* / protein phosphatase 3 catalytic subunit gamma* / protein phosphatase 3, catalytic subuni...  / complex
 ENSDARG00000076297 nfatc3a / nuclear factor of activated T cells 3a / Q12968* / NFATC3* / nuclear factor of activated T cells 3* / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3*  / complex / reaction
 ENSDARG00000079972 nfatc2b / nuclear factor of activated T cells 2b / NFATC2* / Q13469* / nuclear factor of activated T cells 2*  / complex / reaction
 ENSDARG00000100927 nfatc2a / nuclear factor of activated T cells 2a / NFATC2* / Q13469* / Q60591* / nuclear factor of activated T cells 2* / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2*  / reaction / complex
 ENSDARG00000100825 calm2a / calm2b / calm3a / Q6PI52 / calmodulin 2a (phosphorylase kinase, delta)  / complex / reaction
 ENSDARG00000087993 bada / BCL2 associated agonist of cell death a / BAD* / Q92934* / BCL2 associated agonist of cell death*  / reaction
 ENSDARG00000054937 badb / BCL2 associated agonist of cell death b / BAD* / Q61337* / Q92934* / BCL2 associated agonist of cell death*  / reaction
 ENSDARG00000014962 ppp3cca / protein phosphatase 3, catalytic subunit, gamma isozyme, a / P48455* / PPP3CC* / P48454* / protein phosphatase 3 catalytic subunit gamma* / protein phosphatase 3, catalytic subuni...  / complex






 

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