ENSGALG00000039498


Gallus gallus

Features
Gene ID: ENSGALG00000039498
  
Biological name :PPP3CA
  
Synonyms : PPP3CA / protein phosphatase 3 catalytic subunit alpha
  
Possible biological names infered from orthology : P63328 / protein phosphatase 3, catalytic subunit, alpha isoform / Q08209
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 60690568
Gene end: 60796629
  
Corresponding Affymetrix probe sets: Gga.1322.1.S1_at (Chicken Array)   Gga.1322.1.S1_a_at (Chicken Array)   Gga.1322.2.A1_at (Chicken Array)   Gga.1322.2.S1_x_at (Chicken Array)   Gga.3869.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000047388
NCBI entrez gene - 395113     See in Manteia.
RefSeq - XM_015285619
RefSeq - XM_015285620
RefSeq - XM_015285621
RefSeq - XM_015285622
RefSeq - XM_015285623
RefSeq - XM_015285618
swissprot - A0A1D5P3Y2
Ensembl - ENSGALG00000039498
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp3caENSDARG00000004988Danio rerio
 ppp3cbENSDARG00000025106Danio rerio
 PPP3CAENSG00000138814Homo sapiens
 P63328ENSMUSG00000028161Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PPP3CB / Gallus gallus protein phosphatase 3 catalytic subunit beta (PPP3CB), mRNA. / P48453* / P16298* / protein phosphatase 3 catalytic subunit beta* / protein phosphatase 3, catalytic su...ENSGALG0000000524382


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR006186  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006606 protein import into nucleus IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0014883 transition between fast and slow fiber IEA
 biological_processGO:0014898 cardiac muscle hypertrophy in response to stress IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0033173 calcineurin-NFAT signaling cascade IEA
 biological_processGO:0033555 multicellular organismal response to stress IEA
 biological_processGO:0035562 negative regulation of chromatin binding IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0045807 positive regulation of endocytosis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048741 skeletal muscle fiber development IEA
 biological_processGO:0050774 negative regulation of dendrite morphogenesis IEA
 biological_processGO:0050804 modulation of chemical synaptic transmission IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress IEA
 biological_processGO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA IEA
 biological_processGO:1905205 positive regulation of connective tissue replacement IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005955 calcineurin complex IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0043197 dendritic spine IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0016018 cyclosporin A binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0033192 calmodulin-dependent protein phosphatase activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
FCERI mediated Ca+2 mobilization
Ca2+ pathway
CLEC7A (Dectin-1) induces NFAT activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007963 NFATC2 / nuclear factor of activated T cells 2 / Q13469* / Q60591* / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2*  / complex
 ENSGALG00000010023 CALM2 / P62149 / Calmodulin / Calm3* / CALM1* / P0DP23* / P0DP26* / P0DP27* / P0DP28* / calmodulin 1*  / complex
 ENSGALG00000042534 NFATC1 / nuclear factor of activated T cells 1 / O95644* / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1*  / complex






 

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