ENSG00000179841


Homo sapiens

Features
Gene ID: ENSG00000179841
  
Biological name :AKAP5
  
Synonyms : AKAP5 / A-kinase anchoring protein 5 / P24588
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q23.3
Gene start: 64465499
Gene end: 64474503
  
Corresponding Affymetrix probe sets: 207800_at (Human Genome U133 Plus 2.0 Array)   230846_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000378207
Ensembl peptide - ENSP00000315615
NCBI entrez gene - 9495     See in Manteia.
OMIM - 604688
RefSeq - NM_004857
RefSeq Peptide - NP_004848
swissprot - P24588
Ensembl - ENSG00000179841
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AKAP5ENSGALG00000011721Gallus gallus
 Akap5ENSMUSG00000021057Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001573  Protein kinase A anchoring, WSK motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006605 protein targeting IEA
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IMP
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0010738 regulation of protein kinase A signaling IMP
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IMP
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane NAS
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0008179 adenylate cyclase binding IPI
 molecular_functionGO:0017124 SH3 domain binding IPI
 molecular_functionGO:0030346 protein phosphatase 2B binding IDA
 molecular_functionGO:0034237 protein kinase A regulatory subunit binding IPI
 molecular_functionGO:0035254 glutamate receptor binding IDA
 molecular_functionGO:0051018 protein kinase A binding TAS
 molecular_functionGO:0097110 scaffold protein binding IPI


Pathways (from Reactome)
Pathway description
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Trafficking of AMPA receptors
ROBO receptors bind AKAP5


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000114302 P13861 / PRKAR2A / protein kinase cAMP-dependent type II regulatory subunit alpha  / complex / reaction
 ENSG00000005249 P31323 / PRKAR2B / protein kinase cAMP-dependent type II regulatory subunit beta  / complex
 ENSG00000140575 IQGAP1 / P46940 / IQ motif containing GTPase activating protein 1  / complex
 ENSG00000072062 P17612 / PRKACA / protein kinase cAMP-activated catalytic subunit alpha  / reaction / complex
 ENSG00000154229 PRKCA / P17252 / protein kinase C alpha  / complex / reaction
 ENSG00000185008 ROBO2 / Q9HCK4 / roundabout guidance receptor 2  / complex / reaction
 ENSG00000107758 P16298 / PPP3CB / protein phosphatase 3 catalytic subunit beta  / reaction / complex
 ENSG00000188191 P31321 / PRKAR1B / protein kinase cAMP-dependent type I regulatory subunit beta  / complex
 ENSG00000108946 P10644 / PRKAR1A / protein kinase cAMP-dependent type I regulatory subunit alpha  / complex
 ENSG00000142875 P22694 / PRKACB / protein kinase cAMP-activated catalytic subunit beta  / reaction / complex
 ENSG00000165059 P22612 / PRKACG / protein kinase cAMP-activated catalytic subunit gamma  / complex / reaction
 ENSG00000154134 ROBO3 / Q96MS0 / roundabout guidance receptor 3  / complex / reaction






 

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