ENSMUSG00000021057


Mus musculus

Features
Gene ID: ENSMUSG00000021057
  
Biological name :Akap5
  
Synonyms : Akap5 / A-kinase anchor protein 5 / D3YVF0
  
Possible biological names infered from orthology : A-kinase anchoring protein 5 / P24588
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C3
Gene start: 76324891
Gene end: 76334153
  
Corresponding Affymetrix probe sets: 10396640 (MoGene1.0st)   1431717_at (Mouse Genome 430 2.0 Array)   1436142_at (Mouse Genome 430 2.0 Array)   1447301_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000093270
Ensembl peptide - ENSMUSP00000114495
Ensembl peptide - ENSMUSP00000134127
NCBI entrez gene - 238276     See in Manteia.
MGI - MGI:2685104
RefSeq - XM_006515842
RefSeq - NM_001101471
RefSeq Peptide - NP_001094941
swissprot - D3YVF0
swissprot - H3BIV5
Ensembl - ENSMUSG00000021057
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AKAP5ENSGALG00000011721Gallus gallus
 AKAP5ENSG00000179841Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001573  Protein kinase A anchoring, WSK motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006605 protein targeting IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISO
 biological_processGO:0010738 regulation of protein kinase A signaling ISO
 biological_processGO:0036394 amylase secretion IMP
 cellular_componentGO:0005856 cytoskeleton IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0008179 adenylate cyclase binding ISO
 molecular_functionGO:0017124 SH3 domain binding ISO
 molecular_functionGO:0030346 protein phosphatase 2B binding ISO
 molecular_functionGO:0034237 protein kinase A regulatory subunit binding ISO
 molecular_functionGO:0035254 glutamate receptor binding ISO
 molecular_functionGO:0097110 scaffold protein binding ISO


Pathways (from Reactome)
Pathway description
Trafficking of AMPA receptors
ROBO receptors bind AKAP5


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Grin1tm1Nak/Grin1tm1Nak
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Grin1tm1Nak/Grin1tm1Nak
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Grin1tm1Nak/Grin1tm1Nak
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Scn5atm1Clhh/Scn5a+
Genetic Background: involves: 129 * 129S/SvEv * C57BL/6J

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Grin1tm1Nak/Grin1tm1Nak
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2

Allelic Composition: Akap5tm2Jsco/Akap5tm2Jsco
Genetic Background: involves: 129 * C57BL/6

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Akap5tm2Jsco/Akap5tm2Jsco
Genetic Background: involves: 129 * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Mir122tm1.1Apts/Mir122tm1.1Apts
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Akap5tm1Jsco/Akap5tm1Jsco,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S * C57BL/6 * DBA

Allelic Composition: Akap5tm1Gsm/Akap5tm1Gsm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Akap5tm1.1Jsco/Akap5tm1.1Jsco
Genetic Background: involves: 129S * C57BL/6

 MP:0002885 abnormal AMPA-mediated synaptic currents "change in the measured amplitude or duration of response to stimulation of AMPA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grin1tm1Nak/Grin1tm1Nak
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2

Allelic Composition: Akap5tm2Jsco/Akap5tm2Jsco
Genetic Background: involves: 129 * C57BL/6

 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
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Allelic Composition: Grin1tm1Nak/Grin1tm1Nak
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Mir122tm1.1Apts/Mir122tm1.1Apts
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Akap5tm1.1Jsco/Akap5tm1.1Jsco
Genetic Background: involves: 129S * C57BL/6

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Akap5tm2Jsco/Akap5tm2Jsco
Genetic Background: involves: 129 * C57BL/6

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Akap5tm2Jsco/Akap5tm2Jsco
Genetic Background: involves: 129 * C57BL/6

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Akap5tm1Jsco/Akap5tm1Jsco,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S * C57BL/6 * DBA

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mir122tm1.1Apts/Mir122tm1.1Apts
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Akap5tm1.1Jsco/Akap5tm1.1Jsco
Genetic Background: involves: 129S * C57BL/6

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Akap5tm2Jsco/Akap5tm2Jsco
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Akap5tm3Jsco/Akap5tm3Jsco
Genetic Background: involves: 129 * C57BL/6

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Akap5tm1.1Jsco/Akap5tm1.1Jsco
Genetic Background: involves: 129S * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mir122tm1.1Apts/Mir122tm1.1Apts
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Akap5tm1.1Jsco/Akap5tm1.1Jsco
Genetic Background: involves: 129S * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Akap5tm1Jsco/Akap5tm1Jsco,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S * C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005469 P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000005034 P68181 / Prkacb / protein kinase, cAMP dependent, catalytic, beta / P22694* / protein kinase cAMP-activated catalytic subunit beta*  / reaction / complex
 ENSMUSG00000032128 Robo3 / roundabout guidance receptor 3 / Q96MS0*  / complex / reaction
 ENSMUSG00000050965 Prkca / protein kinase C, alpha / P17252*  / reaction / complex
 ENSMUSG00000021816 P48453 / Ppp3cb / protein phosphatase 3, catalytic subunit, beta isoform / P16298* / protein phosphatase 3 catalytic subunit beta*  / complex / reaction






 

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