ENSMUSG00000032128


Mus musculus

Features
Gene ID: ENSMUSG00000032128
  
Biological name :Robo3
  
Synonyms : Robo3 / roundabout guidance receptor 3
  
Possible biological names infered from orthology : Q96MS0
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A4
Gene start: 37415669
Gene end: 37433246
  
Corresponding Affymetrix probe sets: 10592303 (MoGene1.0st)   1421565_at (Mouse Genome 430 2.0 Array)   1436634_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034643
Ensembl peptide - ENSMUSP00000150639
Ensembl peptide - ENSMUSP00000110690
NCBI entrez gene - 19649     See in Manteia.
MGI - MGI:1343102
RefSeq - XM_011242427
RefSeq - XM_006510107
RefSeq - XM_011242424
RefSeq - XM_011242425
RefSeq - XM_011242426
RefSeq - NM_001164767
RefSeq Peptide - NP_001158239
swissprot - D3Z4M6
swissprot - A0A1L1SU85
swissprot - E9QPQ1
Ensembl - ENSMUSG00000032128
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 robo3ENSDARG00000005645Danio rerio
 zgc:77784ENSDARG00000042646Danio rerio
 ROBO3ENSGALG00000045816Gallus gallus
 ROBO3ENSG00000154134Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Robo2 / roundabout guidance receptor 2 / Q9HCK4*ENSMUSG0000005251643
Robo1 / roundabout guidance receptor 1 / Q9Y6N7*ENSMUSG0000002288341
Robo4 / roundabout guidance receptor 4 / Q8WZ75*ENSMUSG0000003212517
Cdon / Q32MD9 / Cell adhesion molecule-related/down-regulated by oncos / Q4KMG0* / cell adhesion associated, oncogene regulated*ENSMUSG0000003811915
Boc / BOC cell adhesion associated, oncogene regulated / Q9BWV1*ENSMUSG0000002268715
Ncam2 / O35136 / Neural cell adhesion molecule 2 / O15394*ENSMUSG0000002276212
Ncam1 / neural cell adhesion molecule 1 isoform 3 / P13591* / neural cell adhesion molecule 1*ENSMUSG0000003954212


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR032987  Roundabout homologue 3
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0035385 Roundabout signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0030424 axon IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Regulation of commissural axon pathfinding by SLIT and ROBO
ROBO receptors bind AKAP5


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000846 abnormal medulla oblongata "anomaly in the most caudal region of the brainstem that lies directly rostral to the spinal cord; includes regions responsible for autonomic functions such as digestion, breathing and control of heart rate" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Dbx1tm1Tmj/Dbx1tm1Tmj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000848 abnormal pons "malformed band of nerve fibers in the brain connecting the medulla oblongata and the mesencephalon; this region conveys information about movement from the cerebral hemisphere to the cerebellum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:1776, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Mapk8tm1Jcbr/Mapk8tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Robo3tm1Matl/Robo3tm1Matl,Tg(Mnx1-EGFP)#Tmj/0
Genetic Background: involves: C57BL/6 * DBA

 MP:0000925 abnormal floor plate morphology "malformation or absence of a transient group of neuroepithelial cells located at the ventral midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slit1tm1.1Matl/Slit1tm1.1Matl,Slit2tm1Matl/Slit2tm1Matl,Slit3tm1.1Dor/Slit3+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Robo3tm1Matl/Robo3tm1Matl
Genetic Background: Not Specified

Allelic Composition: Robo3m1J/Robo3m1J
Genetic Background: C57BL/6J-Robo3m1J/GrsrJ

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Robo3tm1.1Ache/Robo3tm1.1Ache
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Robo3tm1Matl/Robo3tm1Matl
Genetic Background: Not Specified

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Robo3m1J/Robo3m1J
Genetic Background: C57BL/6J-Robo3m1J/GrsrJ

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Pdx1tm1Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Pdx1tm1Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Robo3tm1.1Ache/Robo3tm1.1Ache
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Robo3tm1Matl/Robo3tm1Matl
Genetic Background: Not Specified

Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Robo3tm1.1Ache/Robo3tm1.1Ache
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Slit1tm1.1Matl/Slit1tm1.1Matl,Slit2tm1Matl/Slit2tm1Matl,Slit3tm1.1Dor/Slit3+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

Allelic Composition: Robo3tm1Matl/Robo3tm1Matl,Slit1tm1.1Matl/Slit1tm1.1Matl
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Robo3tm1Matl/Robo3tm1Matl,Slit2tm1Matl/Slit2tm1Matl
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Robo3tm1Matl/Robo3tm1Matl,Slit1tm1.1Matl/Slit1tm1.1Matl,Slit2tm1Matl/Slit2tm1Matl
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo3tm1Matl/Robo3tm1Matl
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Robo2tm1Mrt/Robo2tm1Mrt,Robo3tm1Matl/Robo3tm1Matl
Genetic Background: involves: 129/Sv * CD-1

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lhx2tm1Dra/Lhx2tm1Dra,Lhx9tm1Dodd/Lhx9+
Genetic Background: Not Specified

Allelic Composition: Lhx2tm1Dra/Lhx2+,Lhx9tm1Dodd/Lhx9tm1Dodd,Robo3tm1Matl/Robo3+
Genetic Background: Not Specified

 MP:0004738 abnormal brainstem auditory evoked potential "anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0009619 abnormal optokinetic reflex "any anomaly in the nystagmus or deviation of the eyes in response to stimulation of the visual system by movement; normally, this reflex functions to stabilize a moving image on the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010745 abnormal pre-Botzinger complex morphology "any structural anomaly of the group of interneurons within the medulla oblongata s ventral respiratory group that are important for the generation of ventilatory (inspiratory) rhythmogenesis" [PMID:18826652]
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Allelic Composition: Dbx1tm2(cre)Apie/Dbx1+,Robo3tm1.1Ache/Robo3tm1.1Ache
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010746 abnormal pre-Botzinger complex physiology "any functional anomaly of the group of interneurons within the medulla oblongata s ventral respiratory group that are important for the generation of ventilatory (inspiratory) rhythmogenesis" [PMID:18826652]
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Allelic Composition: Pdx1tm1Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dbx1tm2(cre)Apie/Dbx1+,Robo3tm1.1Ache/Robo3tm1.1Ache
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0011042 abnormal horizontal vestibuloocular reflex "any anomaly in the nystagmus or deviation of the eyes in response to stimulation along the horizontal axis of the vestibular system" [MGI:smb]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Pdx1tm1Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dbx1tm2(cre)Apie/Dbx1+,Robo3tm1.1Ache/Robo3tm1.1Ache
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Slit1tm1.1Matl/Slit1tm1.1Matl,Slit2tm1Matl/Slit2tm1Matl,Slit3tm1.1Dor/Slit3+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020902 Ntn1 / O09118 / Netrin-1 / O95631*  / reaction / complex
 ENSMUSG00000021057 Akap5 / D3YVF0 / A-kinase anchor protein 5 / P24588* / A-kinase anchoring protein 5*  / complex / reaction
 ENSMUSG00000050965 Prkca / protein kinase C, alpha / P17252*  / complex / reaction
 ENSMUSG00000060534 Dcc / P70211 / Netrin receptor DCC / P43146* / DCC netrin 1 receptor*  / reaction / complex
 ENSMUSG00000022454 Nell2 / Q61220 / Mus musculus NEL-like 2 (Nell2), transcript variant 1, mRNA. / Q99435* / neural EGFL like 2*  / reaction / complex
 ENSMUSG00000052516 Robo2 / roundabout guidance receptor 2 / Q9HCK4*  / complex






 

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