ENSDARG00000005645


Danio rerio

Features
Gene ID: ENSDARG00000005645
  
Biological name :robo3
  
Synonyms : robo3 / roundabout, axon guidance receptor, homolog 3 (Drosophila)
  
Possible biological names infered from orthology : Q96MS0 / roundabout guidance receptor 3
  
Species: Danio rerio
  
Chr. number: 10
Strand: -1
Band:
Gene start: 31298972
Gene end: 31563049
  
Corresponding Affymetrix probe sets: Dr.11720.2.S1_a_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000157596
Ensembl peptide - ENSDARP00000003540
Ensembl peptide - ENSDARP00000027377
NCBI entrez gene - 30770     See in Manteia.
RefSeq - NM_001328416
RefSeq - XM_005172636
RefSeq - XM_005172637
RefSeq - XM_005172638
RefSeq Peptide - NP_001315345
swissprot - F1QFK4
swissprot - A8DZ85
ZFIN ID - ZDB-GENE-000209-4
Ensembl - ENSDARG00000005645
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ROBO3ENSGALG00000045816Gallus gallus
 ROBO3ENSG00000154134Homo sapiens
 Robo3ENSMUSG00000032128Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
robo1 / roundabout, axon guidance receptor, homolog 1 (Drosophila) / Q9Y6N7* / roundabout guidance receptor 1*ENSDARG0000002678446
robo2 / roundabout, axon guidance receptor, homolog 2 (Drosophila)ENSDARG0000001489141
robo4 / roundabout, axon guidance receptor, homolog 4 (Drosophila) / Q8WZ75* / roundabout guidance receptor 4*ENSDARG0000000938719
boc / BOC cell adhesion associated, oncogene regulated / Q9BWV1*ENSDARG0000007433514
ncam1b / neural cell adhesion molecule 1b / NCAM1* / P13591* / neural cell adhesion molecule 1* / neural cell adhesion molecule 1 isoform 3 *ENSDARG0000000722013
cdon / cell adhesion associated, oncogene regulated / Q32MD9* / Q4KMG0* / Cell adhesion molecule-related/down-regulated by oncos *ENSDARG0000006132813
ncam1a / neural cell adhesion molecule 1a / NCAM1* / P13591* / neural cell adhesion molecule 1* / neural cell adhesion molecule 1 isoform 3 *ENSDARG0000005618112
ncam2 / neural cell adhesion molecule 2 / O15394* / O35136*ENSDARG0000001746612
ncam3 / neural cell adhesion molecule 3ENSDARG000000895869
zgc:77784 / ROBO3* / Q96MS0* / roundabout guidance receptor 3*ENSDARG000000426468
robo2 / roundabout, axon guidance receptor, homolog 2 (Drosophila)ENSDARG000000783667
BX908388.2ENSDARG000001137744


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR032987  Roundabout homologue 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0016199 axon midline choice point recognition IMP
 biological_processGO:0035385 Roundabout signaling pathway IEA
 biological_processGO:0048264 determination of ventral identity IMP
 biological_processGO:0048675 axon extension IMP
 biological_processGO:0071679 commissural neuron axon guidance IMP
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000059 postoptic commissure postoptic commissure increased width , abnormal
postoptic commissure decreased width , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism movement behavioral quality , abnormal
Show

 ZFA:0001117 post-vent region post-vent region movement quality , abnormal
Show

 ZFA:0001659 diencephalic nucleus diencephalic nucleus axon displaced to hindbrain lateral region, abnormal
Show

 ZFA:0001692 hindbrain commissure hindbrain commissure disorganized , abnormal
Show

 ZFA:0009149 Mauthner neuron Mauthner neuron axon mislocalised , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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