ENSDARG00000026784


Danio rerio

Features
Gene ID: ENSDARG00000026784
  
Biological name :robo1
  
Synonyms : robo1 / roundabout, axon guidance receptor, homolog 1 (Drosophila)
  
Possible biological names infered from orthology : Q9Y6N7 / roundabout guidance receptor 1
  
Species: Danio rerio
  
Chr. number: 15
Strand: -1
Band:
Gene start: 39277099
Gene end: 39820491
  
Corresponding Affymetrix probe sets: Dr.11719.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000123319
Ensembl peptide - ENSDARP00000087907
Ensembl peptide - ENSDARP00000123614
swissprot - A2CEN2
swissprot - A2CEN3
swissprot - F1R2D2
ZFIN ID - ZDB-GENE-000209-3
Ensembl - ENSDARG00000026784
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000042104Gallus gallus
 ROBO1ENSGALG00000015511Gallus gallus
 ROBO1ENSG00000169855Homo sapiens
 Robo1ENSMUSG00000022883Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
robo3 / roundabout, axon guidance receptor, homolog 3 (Drosophila) / Q96MS0* / roundabout guidance receptor 3*ENSDARG0000000564539
robo2 / roundabout, axon guidance receptor, homolog 2 (Drosophila)ENSDARG0000001489139
robo4 / roundabout, axon guidance receptor, homolog 4 (Drosophila) / Q8WZ75* / roundabout guidance receptor 4*ENSDARG0000000938721
cdon / cell adhesion associated, oncogene regulated / Q32MD9* / Q4KMG0* / Cell adhesion molecule-related/down-regulated by oncos *ENSDARG0000006132812
boc / BOC cell adhesion associated, oncogene regulated / Q9BWV1*ENSDARG0000007433512
ncam1a / neural cell adhesion molecule 1a / NCAM1* / P13591* / neural cell adhesion molecule 1* / neural cell adhesion molecule 1 isoform 3 *ENSDARG0000005618111
ncam1b / neural cell adhesion molecule 1b / NCAM1* / P13591* / neural cell adhesion molecule 1* / neural cell adhesion molecule 1 isoform 3 *ENSDARG0000000722011
ncam2 / neural cell adhesion molecule 2 / O15394* / O35136*ENSDARG0000001746610
ncam3 / neural cell adhesion molecule 3ENSDARG000000895868
zgc:77784 / ROBO3* / Q96MS0* / roundabout guidance receptor 3*ENSDARG000000426466
robo2 / roundabout, axon guidance receptor, homolog 2 (Drosophila)ENSDARG000000783666
BX908388.2ENSDARG000001137744


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR032986  Roundabout homologue 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003262 endocardial progenitor cell migration to the midline involved in heart field formation IGI
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007507 heart development IEA
 biological_processGO:0035385 Roundabout signaling pathway IEA


Pathways (from Reactome)
Pathway description
Signaling by ROBO receptors
Role of ABL in ROBO-SLIT signaling
SLIT2:ROBO1 increases RHOA activity
Regulation of expression of SLITs and ROBOs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000059 postoptic commissure postoptic commissure increased width , abnormal
Show

 ZFA:0001319 myocardium myocardium mislocalised , abnormal
Show

 ZFA:0001320 endocardium endocardium mislocalised , abnormal
endocardium cell malformed , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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