ENSGALG00000015511


Gallus gallus

Features
Gene ID: ENSGALG00000015511
  
Biological name :ROBO1
  
Synonyms : ROBO1 / roundabout guidance receptor 1
  
Possible biological names infered from orthology : Q9Y6N7
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 96489993
Gene end: 96603886
  
Corresponding Affymetrix probe sets: Gga.11034.1.S1_at (Chicken Array)   Gga.18589.1.A1_at (Chicken Array)   Gga.18589.1.S1_at (Chicken Array)   Gga.908.1.S1_at (Chicken Array)   GgaAffx.24698.1.S1_at (Chicken Array)   GgaAffx.24698.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000043510
Ensembl peptide - ENSGALP00000043746
Ensembl peptide - ENSGALP00000024963
NCBI entrez gene - 395292     See in Manteia.
RefSeq - XM_416673
RefSeq - XM_015298492
RefSeq - XM_015298510
RefSeq - XM_015298516
RefSeq - XM_004938345
RefSeq - XM_015298481
RefSeq - XM_015298487
swissprot - A0A1D5NTT9
swissprot - F1NR30
swissprot - A0A1D5NT57
Ensembl - ENSGALG00000015511
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 robo1ENSDARG00000026784Danio rerio
 ROBO1ENSG00000169855Homo sapiens
 Robo1ENSMUSG00000022883Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ROBO2 / roundabout guidance receptor 2 / Q9HCK4*ENSGALG0000001551944
ROBO3 / roundabout guidance receptor 3 / Q96MS0*ENSGALG0000004581632
ROBO4* / Q8WZ75* / roundabout guidance receptor 4*ENSGALG0000004308817
NCAM1 / Gallus gallus neural cell adhesion molecule 1 (NCAM1), transcript variant 2, mRNA. / P13591* / neural cell adhesion molecule 1* / neural cell adhesion molecule 1 isoform 3 *ENSGALG0000000783914
BOC / BOC cell adhesion associated, oncogene regulated / Q9BWV1*ENSGALG0000001515213
CDON / cell adhesion associated, oncogene regulated / Q32MD9* / Q4KMG0* / Cell adhesion molecule-related/down-regulated by oncos *ENSGALG0000003541912
NCAM2 / neural cell adhesion molecule 2 / O15394* / O35136*ENSGALG0000001573710
ENSGALG000000288631
ENSGALG000000421041


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR032986  Roundabout homologue 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0021836 chemorepulsion involved in postnatal olfactory bulb interneuron migration IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0033600 negative regulation of mammary gland epithelial cell proliferation IEA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IEA
 biological_processGO:0035385 Roundabout signaling pathway IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0050772 positive regulation of axonogenesis IEA
 biological_processGO:0050925 negative regulation of negative chemotaxis IEA
 biological_processGO:0070100 negative regulation of chemokine-mediated signaling pathway IEA
 biological_processGO:1900748 positive regulation of vascular endothelial growth factor signaling pathway IEA
 cellular_componentGO:0005623 cell IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0030275 LRR domain binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Signaling by ROBO receptors
Regulation of commissural axon pathfinding by SLIT and ROBO
Role of ABL in ROBO-SLIT signaling
SLIT2:ROBO1 increases RHOA activity
Regulation of expression of SLITs and ROBOs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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