Manteia - Molecule gene

ENSMUSG00000022883

Mus musculus

Features

Gene ID:	ENSMUSG00000022883

Biological name :	Robo1

Synonyms :	Robo1 / roundabout guidance receptor 1

Possible biological names infered from orthology :	Q9Y6N7

Species:	Mus musculus

Chr. number:	16
Strand:	1
Band:	C3.1
Gene start:	72663149
Gene end:	73046095

Corresponding Affymetrix probe sets:	10436519 (MoGene1.0st) 1427231_at (Mouse Genome 430 2.0 Array) 1457407_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000023600 NCBI entrez gene - 19876 See in Manteia. MGI - MGI:1274781 RefSeq - XM_017316894 RefSeq - NM_019413 RefSeq - XM_011246106 RefSeq - XM_017316893 RefSeq - XM_006522957 RefSeq - XM_006522958 RefSeq - XM_006522960 RefSeq - XM_006522961 RefSeq - XM_006522962 RefSeq - XM_006522963 RefSeq - XM_006522964 RefSeq - XM_006522965 RefSeq - XM_011246105 RefSeq Peptide - NP_062286 swissprot - G5E843 Ensembl - ENSMUSG00000022883

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
robo1	ENSDARG00000026784	Danio rerio
ROBO1	ENSGALG00000015511	Gallus gallus
ROBO1	ENSG00000169855	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Robo2 / roundabout guidance receptor 2 / Q9HCK4*	ENSMUSG00000052516	49
Robo3 / roundabout guidance receptor 3 / Q96MS0*	ENSMUSG00000032128	36
Robo4 / roundabout guidance receptor 4 / Q8WZ75*	ENSMUSG00000032125	18
Cdon / Q32MD9 / Cell adhesion molecule-related/down-regulated by oncos / Q4KMG0* / cell adhesion associated, oncogene regulated*	ENSMUSG00000038119	15
Boc / BOC cell adhesion associated, oncogene regulated / Q9BWV1*	ENSMUSG00000022687	14
Ncam2 / O35136 / Neural cell adhesion molecule 2 / O15394*	ENSMUSG00000022762	12
Ncam1 / neural cell adhesion molecule 1 isoform 3 / P13591* / neural cell adhesion molecule 1*	ENSMUSG00000039542	12

Protein motifs (from Interpro)

Interpro ID	Name
IPR003598	Immunoglobulin subtype 2
IPR003599	Immunoglobulin subtype
IPR003961	Fibronectin type III
IPR007110	Immunoglobulin-like domain
IPR013098	Immunoglobulin I-set
IPR013106	Immunoglobulin V-set domain
IPR013783	Immunoglobulin-like fold
IPR032986	Roundabout homologue 1
IPR036116	Fibronectin type III superfamily
IPR036179	Immunoglobulin-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002042	cell migration involved in sprouting angiogenesis	IEA
biological_process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IEA
biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	IEA
biological_process	GO:0007411	axon guidance	IEA
biological_process	GO:0007507	heart development	IEA
biological_process	GO:0021836	chemorepulsion involved in postnatal olfactory bulb interneuron migration	IEA
biological_process	GO:0030336	negative regulation of cell migration	IEA
biological_process	GO:0033600	negative regulation of mammary gland epithelial cell proliferation	IEA
biological_process	GO:0035025	positive regulation of Rho protein signal transduction	IEA
biological_process	GO:0035385	Roundabout signaling pathway	IEA
biological_process	GO:0043406	positive regulation of MAP kinase activity	IEA
biological_process	GO:0050772	positive regulation of axonogenesis	IEA
biological_process	GO:0050925	negative regulation of negative chemotaxis	IEA
biological_process	GO:0070100	negative regulation of chemokine-mediated signaling pathway	IEA
biological_process	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0009986	cell surface	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0030275	LRR domain binding	IEA
molecular_function	GO:0042802	identical protein binding	IEA

Pathways (from Reactome)

Pathway description

Signaling by ROBO receptors

Regulation of commissural axon pathfinding by SLIT and ROBO

Role of ABL in ROBO-SLIT signaling

SLIT2:ROBO1 increases RHOA activity

Regulation of expression of SLITs and ROBOs

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000111	cleft palate	"congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2.1(CAG-PSTPIP1)Dtg}/Gt(ROSA)26Sor⁺ Genetic Background:* involves: BALB/cJ * C57BL/6
MP:0000276	right ventricle hypertrophy	"increased size of the right ventricle" [J:33629]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2.1(CAG-PSTPIP1)Dtg}/Gt(ROSA)26Sor⁺ Genetic Background:* involves: BALB/cJ * C57BL/6
MP:0000284	double outlet right ventricle	"both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2.1(CAG-PSTPIP1)Dtg}/Gt(ROSA)26Sor⁺ Genetic Background:* involves: BALB/cJ * C57BL/6
MP:0000474	abnormal foregut morphology	"malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802]	Show Allelic Composition: Hoxa2^tm2.1Fmr/Hoxa2^tm2.1Fmr,Hoxb2^tm2.2Fmr/Hoxb2^tm2.2Fmr Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Rilm/Robo2^tm1Rilm,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129 * 129X1/SvJ
MP:0000519	hydronephrosis	"dilation of the pelvis and calices of one or both kidneys" [J:56641]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2.1(CAG-PSTPIP1)Dtg}/Gt(ROSA)26Sor⁺ Genetic Background:* involves: BALB/cJ * C57BL/6
MP:0000536	hydroureter	"distention of the ureter with urine, due to blockage from any cause" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:Cml, J:13044]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2.1(CAG-PSTPIP1)Dtg}/Gt(ROSA)26Sor⁺ Genetic Background:* involves: BALB/cJ * C57BL/6
MP:0000653	abnormal sex gland morphology	"anomalous structure of any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2.1(CAG-PSTPIP1)Dtg}/Gt(ROSA)26Sor⁺ Genetic Background:* involves: BALB/cJ * C57BL/6
MP:0000780	abnormal corpus callosum morphology	"malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kmt2a^tm1Djab/Kmt2a^tm1Djab Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0000781	reduced size of corpus callosum	"smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Kmt2a^tm1Djab/Kmt2a^tm1Djab Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Mrt/Robo2^tm1Mrt Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
MP:0001175	abnormal lung morphology	"malformed organ of respiration" [J:35802]	Show Allelic Composition: Tulp3^tm1Jng/Tulp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0001176	abnormal lung development	"malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Tulp3^tm1Jng/Tulp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0001179	thicker alveolar septa		Show Allelic Composition: Tulp3^tm1Jng/Tulp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0001438	aphagia	"inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]	Show Allelic Composition: Tulp3^tm1Jng/Tulp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Mrt/Robo2^tm1Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0001953	respiratory failure	"cessation of or failure to commence breathing" [MGI:cls, J:60159]	Show Allelic Composition: Tulp3^tm1Jng/Tulp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Mrt/Robo2^tm1Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Rilm/Robo2^tm1Rilm,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129 * 129X1/SvJ
MP:0002027	lung adenocarcinoma	"malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]	Show Allelic Composition: Id2^tm1Ago/Id2^tm1Ago Genetic Background: B6.129-Id2^tm1Ago
MP:0002038	carcinoma	"malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]	Show Allelic Composition: Id2^tm1Ago/Id2^tm1Ago Genetic Background: B6.129-Id2^tm1Ago
MP:0002058	neonatal lethality	"death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Rilm/Robo2^tm1Rilm,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129 * 129X1/SvJ
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2.1(CAG-PSTPIP1)Dtg}/Gt(ROSA)26Sor⁺ Genetic Background:* involves: BALB/cJ * C57BL/6
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Rilm/Robo2^tm1Rilm,Shh^{tm1(EGFP/cre)Cjt}/Shh⁺ Genetic Background: involves: 129 Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Rilm/Robo2^tm1Rilm,Tbx4^tm1(cre)Tmj/Tbx4⁺ Genetic Background: involves: 129
MP:0002184	abnormal innervation	"the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Rilm/Robo2^tm1Rilm,Shh^{tm1(EGFP/cre)Cjt}/Shh⁺ Genetic Background: involves: 129
MP:0002199	abnormal brain commissure morphology	"absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kmt2a^tm1Djab/Kmt2a^tm1Djab Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0002264	abnormal bronchus morphology	"any structural anomaly of of the upper conducting airways of the lung; these airways arise from the terminus of the trachea " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tulp3^tm1Jng/Tulp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0002267	abnormal bronchiole morphology	"any structural anomaly of the conducting airway of the lungs found terminal to the bronchi. These structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching. " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Tulp3^tm1Jng/Tulp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0002270	abnormal alveoli morphology	"any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tulp3^tm1Jng/Tulp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0002279	abnormal diaphragm morphology	"structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Mrt/Robo2^tm1Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0002625	left ventricle hypertrophy	"increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2.1(CAG-PSTPIP1)Dtg}/Gt(ROSA)26Sor⁺ Genetic Background:* involves: BALB/cJ * C57BL/6
MP:0002639	micrognathia	"abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2.1(CAG-PSTPIP1)Dtg}/Gt(ROSA)26Sor⁺ Genetic Background:* involves: BALB/cJ * C57BL/6
MP:0002961	abnormal axon guidance	"defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Gdnf^tm1Rosl/Gdnf⁺,Slit2^tm1Matl/Slit2^tm1Matl Genetic Background: involves: 129S2/SvPas Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo3^tm1Matl/Robo3^tm1Matl Genetic Background: involves: 129/Sv * CD-1 Allelic Composition: Robo1^tm1.1Ljr/Robo1^tm1.1Ljr Genetic Background: B6.129-Robo1^tm1.1Ljr Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Mrt/Robo2^tm1Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Mrt/Robo2^tm1Mrt Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
MP:0003651	abnormal axon outgrowth	"defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]	Show Allelic Composition: Robo1^tm1.1Ljr/Robo1^tm1.1Ljr Genetic Background: B6.129-Robo1^tm1.1Ljr
MP:0003924	herniated diaphragm	"protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Rilm/Robo2^tm1Rilm,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129 * 129X1/SvJ
MP:0004274	abnormal embryonic/fetal subventricular zone morphology	"any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]	Show Allelic Composition: Xist^tm1Jae/Xist^tm2.1Jae Genetic Background: involves: 129S4/SvJae
MP:0004550	short trachea	"reduced length of the tube descending from the larynx and branching into the right and left main bronchi" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Mrt/Robo2^tm1Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0004787	abnormal dorsal aorta morphology	"any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Mrt/Robo2^tm1Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0005237	abnormal olfactory tract morphology	"structural anomaly of the nervelike, white band composed primarily of nerve fibers originating from the mitral cells and tufted cells of the olfactory bulb, but also containing the scattered cells of the anterior olfactory nucleus " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34460]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Mrt/Robo2^tm1Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl Genetic Background: involves: 129X1/SvJ
MP:0005488	bronchial epithelial hyperplasia	"increased numbers of cells lining the inner surfaces of the bronchi" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tulp3^tm1Jng/Tulp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0006009	abnormal neuronal migration	"defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Robo1^tm1.1Ljr/Robo1^tm1.1Ljr Genetic Background: B6.129-Robo1^tm1.1Ljr
MP:0008219	abnormal dorsal telencephalic commissure morphology	"any structural anomaly of the fiber tracts that connect the dorsal region of the two cerebral hemispheres and span the longitudinal fissure, including the corpus callosum and hippocampal commissure" [PMID:16715082]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Mrt/Robo2^tm1Mrt Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
MP:0008221	abnormal hippocampal commissure morphology	"any structural anomaly of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Robo1^tm1.1Ljr/Robo1^tm1.1Ljr Genetic Background: B6.129-Robo1^tm1.1Ljr
MP:0008222	decreased hippocampal commissure size	"reduced size of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Robo1^tm1.1Ljr/Robo1^tm1.1Ljr Genetic Background: B6.129-Robo1^tm1.1Ljr
MP:0008225	abnormal anterior commissure morphology	"any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Mrt/Robo2^tm1Mrt Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
MP:0008415	abnormal neurite morphology	"any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]	Show Allelic Composition: Xist^tm1Jae/Xist^tm2.1Jae Genetic Background: involves: 129S4/SvJae
MP:0008528	polycystic kidney	"the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2.1(CAG-PSTPIP1)Dtg}/Gt(ROSA)26Sor⁺ Genetic Background:* involves: BALB/cJ * C57BL/6
MP:0009503	abnormal mammary gland duct morphology	"any structural anomaly of the canals that lead from the lobes of the mammary gland to the tip of the nipple and are responsible for carrying milk toward the nipple in a lactating female" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl Genetic Background: involves: 129X1/SvJ
MP:0009546	absent gastric milk in neonates	"failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Mrt/Robo2^tm1Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0009678	abnormal spinal cord lateral column morphology	"any structural anomaly of the region of white matter of the spinal cord that is located between the dorsal and ventral spinal roots" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Gdnf^tm1Rosl/Gdnf⁺,Slit2^tm1Matl/Slit2^tm1Matl Genetic Background: involves: 129S2/SvPas
MP:0009695	abnormal spinal cord ventral commissure morphology	"any structural anomaly of the band of nerve fibers which cross the midline of the spinal cord ventral to the central canal and posterior grey commissure" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Mrt/Robo2^tm1Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0010173	increased mammary gland epithelium proliferation	"increase in the expansion rate of the cells of the mammary gland epithelium by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl Genetic Background: involves: 129X1/SvJ
MP:0010402	ventricular septal defect	"abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2.1(CAG-PSTPIP1)Dtg}/Gt(ROSA)26Sor⁺ Genetic Background:* involves: BALB/cJ * C57BL/6
MP:0010807	abnormal stomach position or orientation	"the stomach is displaced from the normal left-sided position and/or orientation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Mrt/Robo2^tm1Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0010880	small esophagus	"reduced size of the part of the digestive canal through which food passes from the pharynx to the stomach" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Mrt/Robo2^tm1Mrt Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Rilm/Robo2^tm1Rilm,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129 * 129X1/SvJ
MP:0010881	esophagus hypoplasia	"underdevelopment or decreased size of the esophagus, usually due a reduced number of cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Mrt/Robo2^tm1Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0010900	abnormal pulmonary interalveolar septum morphology	"any structural anomaly of the tissue intervening between two adjacent pulmonary alveoli, which consists of the basement membranes of alveolar-lining epithelium (mostly type I pneumocytes) and capillary endothelium; thicker alveolar septal regions may also contain elastic fibers, collagen, interstitial cells, smooth muscle cells, mast cells, lymphocytes and monocytes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tulp3^tm1Jng/Tulp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Mrt/Robo2^tm1Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Tulp3^tm1Jng/Tulp3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Robo1^tm1.1Ljr/Robo1^tm1.1Ljr Genetic Background: B6.129-Robo1^tm1.1Ljr
MP:0011805	decreased cell migration	"reduced or slower movement of cells from one site to another, often occuring during developmental or chemotactic processes" [GO:0016477, MGI:csmith]	Show Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl,Robo2^tm1Mrt/Robo2^tm1Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0012431	increased lymphoma incidence	"greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]	Show Allelic Composition: Id2^tm1Ago/Id2^tm1Ago Genetic Background: B6.129-Id2^tm1Ago

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000021262	Evl / P70429 / Ena/VASP-like protein / Q9UI08* / Enah/Vasp-like*	/ complex
ENSMUSG00000026842	Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*	/ reaction / complex
ENSMUSG00000045382	Cxcr4 / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA. / P61073* / C-X-C motif chemokine receptor 4*	/ reaction / complex
ENSMUSG00000026596	Abl2 / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) / P42684* / ABL proto-oncogene 2, non-receptor tyrosine kinase*	/ complex / reaction
ENSMUSG00000031558	Slit2 / Q9R1B9 / slit guidance ligand 2 / O94813*	/ complex / reaction
ENSMUSG00000061353	Cxcl12 / P40224 / Stromal cell-derived factor 1 / P48061* / C-X-C motif chemokine ligand 12*	/ reaction / complex
ENSMUSG00000025437	Usp33 / Q8R5K2 / ubiquitin specific peptidase 33 / Q8TEY7*	/ reaction
ENSMUSG00000030403	Vasp / P70460 / vasodilator-stimulated phosphoprotein / P50552*	/ complex
ENSMUSG00000022995	Enah / Q03173 / ENAH, actin regulator / Q8N8S7*	/ complex

1 s.

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