ENSMUSG00000021262


Mus musculus

Features
Gene ID: ENSMUSG00000021262
  
Biological name :Evl
  
Synonyms : Ena/VASP-like protein / Evl / P70429
  
Possible biological names infered from orthology : Enah/Vasp-like / Q9UI08
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: F1
Gene start: 108554720
Gene end: 108688516
  
Corresponding Affymetrix probe sets: 10398267 (MoGene1.0st)   1434920_a_at (Mouse Genome 430 2.0 Array)   1440885_at (Mouse Genome 430 2.0 Array)   1450106_a_at (Mouse Genome 430 2.0 Array)   1458889_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152364
Ensembl peptide - ENSMUSP00000105480
Ensembl peptide - ENSMUSP00000152440
Ensembl peptide - ENSMUSP00000133072
Ensembl peptide - ENSMUSP00000021689
Ensembl peptide - ENSMUSP00000076916
NCBI entrez gene - 14026     See in Manteia.
MGI - MGI:1194884
RefSeq - XM_006515471
RefSeq - NM_001163394
RefSeq - NM_001163395
RefSeq - NM_001163396
RefSeq - NM_007965
RefSeq - XM_006515470
RefSeq Peptide - NP_001156867
RefSeq Peptide - NP_001156866
RefSeq Peptide - NP_001156868
RefSeq Peptide - NP_031991
swissprot - A0A1Y7VJA2
swissprot - A0A1Y7VNI5
swissprot - E9PVP4
swissprot - P70429
swissprot - F8WJB9
Ensembl - ENSMUSG00000021262
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 evlaENSDARG00000035650Danio rerio
 EVLENSGALG00000011209Gallus gallus
 EVLENSG00000196405Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Enah / Q03173 / ENAH, actin regulator / Q8N8S7*ENSMUSG0000002299555
Vasp / P70460 / vasodilator-stimulated phosphoprotein / P50552*ENSMUSG0000003040343
Q924S7 / Spred2 / Sprouty-related, EVH1 domain-containing protein 2 / Q7Z698* / sprouty related EVH1 domain containing 2*ENSMUSG0000004567117
Q924S8 / Spred1 / Sprouty-related, EVH1 domain-containing protein 1 / Q7Z699* / sprouty related EVH1 domain containing 1*ENSMUSG0000002735117
Spred3 / sprouty related EVH1 domain containing 3 / Q2MJR0*ENSMUSG0000003723917


Protein motifs (from Interpro)
Interpro ID Name
 IPR000697  WH1/EVH1 domain
 IPR011993  PH-like domain superfamily
 IPR014885  VASP tetramerisation
 IPR017354  Vasodilator-stimulated phosphoprotein/ENA/VASP-like
 IPR034319  ENA/VASP-like protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007411 axon guidance NAS
 biological_processGO:0008154 actin polymerization or depolymerization IEA
 biological_processGO:0010633 negative regulation of epithelial cell migration IEA
 biological_processGO:0030048 actin filament-based movement NAS
 biological_processGO:0030168 platelet activation NAS
 biological_processGO:0030838 positive regulation of actin filament polymerization IDA
 biological_processGO:0045010 actin nucleation IEA
 biological_processGO:0051016 barbed-end actin filament capping NAS
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 biological_processGO:1900028 negative regulation of ruffle assembly IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005522 profilin binding IDA
 molecular_functionGO:0017124 SH3 domain binding IEA


Pathways (from Reactome)
Pathway description
Signaling by ROBO receptors
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Tll1b2b2476Clo/Tll1b2b2476Clo
Genetic Background: C57BL/6J-Tll1b2b2476Clo

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Epas1tm1b(EUCOMM)Hmgu/Epas1+
Genetic Background: C57BL/6N-Epas1tm1b(EUCOMM)Hmgu/H

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Enahtm1Fbg/Enahtm1Fbg,Evltm1Fbg/Evltm1Fbg,Vasptm1Ref/Vasptm1Ref
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Enahtm1Fbg/Enahtm1Fbg,Evltm1Fbg/Evltm1Fbg,Vasptm1Ref/Vasptm1Ref
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Serpine2tm1Dmn/Serpine2tm1Dmn,Tg(Thy1-Serpine2)2Dmn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003648 abnormal radial glial cell morphology "anomalous structure, number, or composition of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Enahtm1Fbg/Enahtm1Fbg,Evltm1Fbg/Evltm1Fbg,Vasptm1Ref/Vasptm1Ref
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0004056 abnormal myocardial compact layer morphology "malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tll1b2b2476Clo/Tll1b2b2476Clo
Genetic Background: C57BL/6J-Tll1b2b2476Clo

 MP:0004151 hypoferremia "less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Epas1tm1b(EUCOMM)Hmgu/Epas1+
Genetic Background: C57BL/6N-Epas1tm1b(EUCOMM)Hmgu/H

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Enahtm1Fbg/Enahtm1Fbg,Evltm1Fbg/Evltm1Fbg,Vasptm1Ref/Vasptm1Ref
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0008129 absent brain internal capsule "absence of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Enahtm1Fbg/Enahtm1Fbg,Evltm1Fbg/Evltm1Fbg,Vasptm1Ref/Vasptm1Ref
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
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Allelic Composition: Enahtm1Fbg/Enahtm1Fbg,Evltm1Fbg/Evltm1Fbg,Vasptm1Ref/Vasptm1Ref
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
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Allelic Composition: Enahtm1Fbg/Enahtm1Fbg,Evltm1Fbg/Evltm1Fbg,Vasptm1Ref/Vasptm1Ref
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0008457 abnormal cortical intermediate zone morphology "any structural anomaly of the region of the developing mammalian cortex that extends between the ventricular zone and the cortical plate (CP); normally, the IZ is a region of tangential migration of cells, and at midgestation, the lower part of the IZ develops into the subventricular zone" [PMID:10632599]
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Allelic Composition: Enahtm1Fbg/Enahtm1Fbg,Evltm1Fbg/Evltm1Fbg,Vasptm1Ref/Vasptm1Ref
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Epas1tm1b(EUCOMM)Hmgu/Epas1+
Genetic Background: C57BL/6N-Epas1tm1b(EUCOMM)Hmgu/H

 MP:0009026 abnormal brain pia mater morphology "any structural anomaly of the fibrous membrane forming the innermost of the three coverings that surrounds the brain within the cranial cavity that is firmly attached to the glial capsule" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Enahtm1Fbg/Enahtm1Fbg,Evltm1Fbg/Evltm1Fbg,Vasptm1Ref/Vasptm1Ref
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0009027 abnormal subarachnoid space morphology "any structural anomaly of the space between the arachnoid and dura mater that is traversed by fibrous trabeculae and contains cerebrospinal fluid" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Enahtm1Fbg/Enahtm1Fbg,Evltm1Fbg/Evltm1Fbg,Vasptm1Ref/Vasptm1Ref
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Tll1b2b2476Clo/Tll1b2b2476Clo
Genetic Background: C57BL/6J-Tll1b2b2476Clo

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
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Allelic Composition: Tll1b2b2476Clo/Tll1b2b2476Clo
Genetic Background: C57BL/6J-Tll1b2b2476Clo

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Enahtm1Fbg/Enahtm1Fbg,Evltm1Fbg/Evltm1Fbg,Vasptm1Ref/Vasptm1Ref
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0011112 partial lethality during fetal growth through weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Enahtm1Fbg/Enahtm1Fbg,Evltm1Fbg/Evltm1Fbg,Vasptm1Ref/Vasptm1Ref
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Enahtm1Fbg/Enahtm1Fbg,Evltm1Fbg/Evltm1Fbg,Vasptm1Ref/Vasptm1Ref
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0011667 double outlet right ventricle with atrioventricular septal defect "a form of DORV in which there is also a complete atrioventricular canal" [MGI:csmith]
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Allelic Composition: Tll1b2b2476Clo/Tll1b2b2476Clo
Genetic Background: C57BL/6J-Tll1b2b2476Clo

 MP:0011724 ectopic cortical neuron "appearance of a cerebral cortical neuron or group of cerebral cortical neurons in a region where it is not normally found" [MGI:csmith]
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Allelic Composition: Enahtm1Fbg/Enahtm1Fbg,Evltm1Fbg/Evltm1Fbg,Vasptm1Ref/Vasptm1Ref
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Epas1tm1b(EUCOMM)Hmgu/Epas1+
Genetic Background: C57BL/6N-Epas1tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021262 Evl / P70429 / Ena/VASP-like protein / Q9UI08* / Enah/Vasp-like*  / complex
 ENSMUSG00000031558 Slit2 / Q9R1B9 / slit guidance ligand 2 / O94813*  / complex
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / complex / reaction
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / complex / reaction
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / complex / reaction
 ENSMUSG00000024456 1 / Diaph1 / O08808 / O60610* / diaphanous related formin 1*  / reaction / complex
 ENSMUSG00000042292 Mkl1 / Q8K4J6 / MKL/myocardin-like protein 1 / Q969V6* / megakaryoblastic leukemia (translocation) 1*  / reaction
 ENSMUSG00000022883 Robo1 / roundabout guidance receptor 1 / Q9Y6N7*  / complex






 

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