ENSMUSG00000027351


Mus musculus

Features
Gene ID: ENSMUSG00000027351
  
Biological name :Spred1
  
Synonyms : Q924S8 / Spred1 / Sprouty-related, EVH1 domain-containing protein 1
  
Possible biological names infered from orthology : Q7Z699 / sprouty related EVH1 domain containing 1
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 117121374
Gene end: 117182279
  
Corresponding Affymetrix probe sets: 10474671 (MoGene1.0st)   1423160_at (Mouse Genome 430 2.0 Array)   1423161_s_at (Mouse Genome 430 2.0 Array)   1423162_s_at (Mouse Genome 430 2.0 Array)   1428777_at (Mouse Genome 430 2.0 Array)   1443652_x_at (Mouse Genome 430 2.0 Array)   1445228_at (Mouse Genome 430 2.0 Array)   1452911_at (Mouse Genome 430 2.0 Array)   1460116_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028829
Ensembl peptide - ENSMUSP00000106526
NCBI entrez gene - 114715     See in Manteia.
MGI - MGI:2150016
RefSeq - NM_001277256
RefSeq - NM_033524
RefSeq Peptide - NP_001264185
RefSeq Peptide - NP_277059
swissprot - Q924S8
Ensembl - ENSMUSG00000027351
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spred1ENSDARG00000041449Danio rerio
 SPRED1ENSGALG00000028203Gallus gallus
 Q7Z699ENSG00000166068Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q924S7 / Spred2 / Sprouty-related, EVH1 domain-containing protein 2 / Q7Z698* / sprouty related EVH1 domain containing 2*ENSMUSG0000004567151
Spred3 / sprouty related EVH1 domain containing 3 / Q2MJR0*ENSMUSG0000003723934
Enah / Q03173 / ENAH, actin regulator / Q8N8S7*ENSMUSG0000002299518
Vasp / P70460 / vasodilator-stimulated phosphoprotein / P50552*ENSMUSG0000003040316
Evl / P70429 / Ena/VASP-like protein / Q9UI08* / Enah/Vasp-like*ENSMUSG0000002126216


Protein motifs (from Interpro)
Interpro ID Name
 IPR000697  WH1/EVH1 domain
 IPR007875  Sprouty
 IPR011993  PH-like domain superfamily
 IPR023337  c-Kit-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity IMP
 biological_processGO:0006469 negative regulation of protein kinase activity ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0010801 negative regulation of peptidyl-threonine phosphorylation IDA
 biological_processGO:0010923 negative regulation of phosphatase activity ISS
 biological_processGO:0016525 negative regulation of angiogenesis ISO
 biological_processGO:0043409 negative regulation of MAPK cascade ISO
 biological_processGO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator IDA
 biological_processGO:0060979 vasculogenesis involved in coronary vascular morphogenesis ISO
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IDA
 biological_processGO:0090311 regulation of protein deacetylation IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 molecular_functionGO:0005173 stem cell factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019902 phosphatase binding ISS
 molecular_functionGO:0030291 protein serine/threonine kinase inhibitor activity IDA


Pathways (from Reactome)
Pathway description
Regulation of RAS by GAPs
FGFRL1 modulation of FGFR1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000324 increased mast cell number "greater than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adartm2Knk/Adar+
Genetic Background: chimera involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Plce1tm1Tkat/Plce1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Plce1tm1Tkat/Plce1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
Show

Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ

 MP:0001952 increased airway responsiveness "more easily provoked into bronchoconstriction in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Plce1tm1Tkat/Plce1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002465 abnormal eosinophil physiology "abnormal function of the leukocyte that stains with eosin and is involved in clearance of parasitic infections and in allergic reactions " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Plce1tm1Tkat/Plce1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
Show

Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ

 MP:0002802 abnormal discrimination learning "defects in the ability to exhibit a differential response to different stimuli that is achieved by the reinforcement of the desired response for each particular stimulus" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plce1tm1Tkat/Plce1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Plce1tm1Tkat/Plce1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Thrbtm1Df/Thrbtm1Df
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ

 MP:0008764 increased mast cell degranulation "increase in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adartm2Knk/Adar+
Genetic Background: chimera involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0030066 short face "an abnormally decreased height (length) of the face" [MGI:anna]
Show

Allelic Composition: Plce1tm1Tkat/Plce1+
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027351 Q924S8 / Spred1 / Sprouty-related, EVH1 domain-containing protein 1 / Q7Z699* / sprouty related EVH1 domain containing 1*  / complex
 ENSMUSG00000008090 Fgfrl1 / Q91V87 / Fibroblast growth factor receptor-like 1 / Q8N441*  / reaction / complex
 ENSMUSG00000020716 Nf1 / Q04690 / Neurofibromin / P21359* / neurofibromin 1*  / complex / reaction






 

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