ENSMUSG00000020716


Mus musculus

Features
Gene ID: ENSMUSG00000020716
  
Biological name :Nf1
  
Synonyms : Neurofibromin / Nf1 / Q04690
  
Possible biological names infered from orthology : neurofibromin 1 / P21359
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 79339693
Gene end: 79581612
  
Corresponding Affymetrix probe sets: 10379262 (MoGene1.0st)   1438067_at (Mouse Genome 430 2.0 Array)   1441523_at (Mouse Genome 430 2.0 Array)   1452525_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071289
Ensembl peptide - ENSMUSP00000103886
Ensembl peptide - ENSMUSP00000120982
Ensembl peptide - ENSMUSP00000151975
NCBI entrez gene - 18015     See in Manteia.
MGI - MGI:97306
RefSeq - XM_006532442
RefSeq - NM_010897
RefSeq - XM_006532438
RefSeq - XM_006532439
RefSeq - XM_006532440
RefSeq - XM_006532441
RefSeq - XM_006532436
RefSeq - XM_006532437
RefSeq Peptide - NP_035027
swissprot - Q04690
swissprot - Q5SYH9
swissprot - A0A1W2P863
Ensembl - ENSMUSG00000020716
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nf1aENSDARG00000012982Danio rerio
 nf1bENSDARG00000004184Danio rerio
 NF1ENSGALG00000005660Gallus gallus
 NF1ENSG00000196712Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001251  CRAL-TRIO lipid binding domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR023152  Ras GTPase-activating protein, conserved site
 IPR036865  CRAL-TRIO lipid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IMP
 biological_processGO:0001649 osteoblast differentiation IMP
 biological_processGO:0001656 metanephros development IMP
 biological_processGO:0001666 response to hypoxia IMP
 biological_processGO:0001889 liver development IMP
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IGI
 biological_processGO:0001952 regulation of cell-matrix adhesion IMP
 biological_processGO:0001953 negative regulation of cell-matrix adhesion IGI
 biological_processGO:0006469 negative regulation of protein kinase activity IMP
 biological_processGO:0007154 cell communication IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007265 Ras protein signal transduction IMP
 biological_processGO:0007406 negative regulation of neuroblast proliferation IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007422 peripheral nervous system development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007519 skeletal muscle tissue development IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IGI
 biological_processGO:0010468 regulation of gene expression IGI
 biological_processGO:0014044 Schwann cell development IMP
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0016525 negative regulation of angiogenesis IGI
 biological_processGO:0021510 spinal cord development IMP
 biological_processGO:0021764 amygdala development IGI
 biological_processGO:0021897 forebrain astrocyte development IMP
 biological_processGO:0021915 neural tube development IGI
 biological_processGO:0021987 cerebral cortex development IMP
 biological_processGO:0022011 myelination in peripheral nervous system IMP
 biological_processGO:0030036 actin cytoskeleton organization IMP
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0030199 collagen fibril organization IMP
 biological_processGO:0030325 adrenal gland development IMP
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0032228 regulation of synaptic transmission, GABAergic IGI
 biological_processGO:0034605 cellular response to heat IDA
 biological_processGO:0035021 negative regulation of Rac protein signal transduction IGI
 biological_processGO:0042060 wound healing IMP
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0042992 obsolete negative regulation of transcription factor import into nucleus IMP
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043087 regulation of GTPase activity ISO
 biological_processGO:0043407 negative regulation of MAP kinase activity IMP
 biological_processGO:0043408 regulation of MAPK cascade IGI
 biological_processGO:0043409 negative regulation of MAPK cascade IEA
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0043525 positive regulation of neuron apoptotic process IMP
 biological_processGO:0043535 regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045124 regulation of bone resorption IMP
 biological_processGO:0045671 negative regulation of osteoclast differentiation IGI
 biological_processGO:0045685 regulation of glial cell differentiation IMP
 biological_processGO:0045762 positive regulation of adenylate cyclase activity IMP
 biological_processGO:0045765 regulation of angiogenesis IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IMP
 biological_processGO:0046929 negative regulation of neurotransmitter secretion IMP
 biological_processGO:0048147 negative regulation of fibroblast proliferation IMP
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IMP
 biological_processGO:0048485 sympathetic nervous system development IMP
 biological_processGO:0048593 camera-type eye morphogenesis IMP
 biological_processGO:0048712 negative regulation of astrocyte differentiation IMP
 biological_processGO:0048715 negative regulation of oligodendrocyte differentiation IMP
 biological_processGO:0048745 smooth muscle tissue development IMP
 biological_processGO:0048820 hair follicle maturation IMP
 biological_processGO:0048844 artery morphogenesis IMP
 biological_processGO:0048853 forebrain morphogenesis IMP
 biological_processGO:0050890 cognition IEA
 biological_processGO:0061534 gamma-aminobutyric acid secretion, neurotransmission IGI
 biological_processGO:0061535 glutamate secretion, neurotransmission IGI
 biological_processGO:0098597 observational learning IGI
 biological_processGO:1900271 regulation of long-term synaptic potentiation IGI
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
 biological_processGO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IBA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005096 GTPase activator activity ISO
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding ISO
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0008429 phosphatidylethanolamine binding IEA
 molecular_functionGO:0031210 phosphatidylcholine binding IEA


Pathways (from Reactome)
Pathway description
Regulation of RAS by GAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000061 fragile skeleton "easily damaged or broken bones" [J:14208]
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Allelic Composition: Gt(ROSA)26Sortm1(Cdkn1c)Jfpa/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Gt(ROSA)26Sortm1(Cdkn1c)Jfpa/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
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Allelic Composition: Nf1tm1Par/Nf1tm1Fcr,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(Cdkn1c)Jfpa/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lrrc17tm1Nik/Lrrc17+,Nf1tm1Par/Nf1tm1Par,Srpk2tm1Nik/Srpk2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0000255 vasculature congestion "obstruction of the normal flux of blood within the blood vessel network" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Rnf7Gt(XE423)Byg/Rnf7Gt(XE423)Byg
Genetic Background: involves: 129 * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0000277 abnormal heart shape "malformation of the form or the patterning of the heart" [J:18048]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0000434 megacephaly "an abnormally large size of the head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000528 delayed kidney development "late onset of the induction and/or differentiation of the kidney" [J:18048]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0000575 dark foot pads "darker color of the foot pads due to excess pigment" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Ext1tm1Yama/Ext1+,Slit2tm1Matl/Slit2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 * SJL

 MP:0000597 delayed hepatic development "late onset of the induction and/or differentiation of the liver" [J:18048]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000633 abnormal pituitary gland morphology "anomalous structure of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000639 abnormal adrenal gland morphology "malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Nf1tm1Par/Nf1tm1Par,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000642 enlarged adrenal glands "increased size of the endocrine gland" [J:40203]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Nf1tm1Par/Nf1tm1Par,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Par,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Nf1tm1Fcr/Nf1tm1Par,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Par,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cpt1cGt(XL823)Byg/Cpt1c+,Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0000733 abnormal muscle development "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0000736 delayed muscle development "late onset of the induction and/or differentiation of skeletal muscle" [J:18048]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (C3H/HeJ x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (CAST/EiJ x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ext1tm1Yama/Ext1+,Slit2tm1Matl/Slit2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 * SJL

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000841 abnormal hindbrain morphology "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0000863 abnormal secondary somatosensory cortex morphology "any malformation or absence of the area of the upper bank of the lateral sulcus that is involved in somatic sensation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1b+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129S1.Cg-Cdkn1btm1Ako Ptentm2.1Ppp Tg(TPO-cre)1Shk

 MP:0000952 abnormal CNS glia "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000959 abnormal somatic sensory system morphology 
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv

Allelic Composition: Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sortm1Fia,Hprttm1(CMV-cre)Brd/Hprt+,Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv * 129S/SvEvBrd

Allelic Composition: Nf1tm1Fcr/Nf1tm1Par,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv

Allelic Composition: Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sor+,Nf1tm1Fcr/Nf1tm1Par,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001008 abnormal sympathetic ganglia morphology "malformed or absent groups of neuronal cell bodies of the autonomic nervous system" [J:18048]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Nf1tm1Par/Nf1tm1Par,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001009 paravertebral ganglia hyperplasia "increase in cell number of the group of neuronal cell bodies of the autonomic nervous system that are located at intervals along the sympathetic trunks" [J:18048]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001010 prevertebral ganglia hyperplasia "increase in cell number of the group of neuronal cell bodies of the autonomic nervous system that are located on the superior part of the abdominal aorta " [J:18048]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Myo5atm1a(KOMP)Wtsi/Myo5atm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Myo5atm1a(KOMP)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sor+,Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Nf1tm1Par/Nf1tm1Par,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001267 enlarged chest "wider diameter, or distended chest cavity" [J:18048]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001272 increased metastatic potential 
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Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Cpt1cGt(XL823)Byg/Cpt1c+,Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1b+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129S1.Cg-Cdkn1btm1Ako Ptentm2.1Ppp Tg(TPO-cre)1Shk

Allelic Composition: Nf1tm1Fcr/Nf1+,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Tyj/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Trp53tm1Elee/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Elee/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (C3H/HeJ x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (CAST/EiJ x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

 MP:0001396 unidirectional circling "circling behavior in one direction only, either clockwise or counterclockwise" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Tyj/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Trp53tm1Elee/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Elee/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Casrtm1Ces/Casr+
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Casrtm1Ces/Casr+
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Nf1tm1Tyj/Nf1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Grin1tm1Stl/Grin1+,Nf1tm1Tyj/Nf1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Tyj/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Trp53tm1Elee/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Elee/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001511 disheveled coat "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001656 focal hepatic necrosis "a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001690 failure of somite differentiation "disorganized or absent somite tissue or somite pattern in development" [J:25248]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Nf1tm1Par/Nf1tm1Par,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002018 malignant tumors "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Nf1tm1Par/Nf1tm1Par,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Nf1tm1Tyj/Nf1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002030 neurofibrosarcoma "malignant neoplasm of fibrous tissue of the nervous system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Nf1tm1Tyj/?,Nstr1C57BL/6J/Nstr1C57BL/6J,Trp53tm1Tyj/?
Genetic Background: involves: 129S2/SvPas * A/J * C57BL/6J

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Nf1tm1Tyj/Nf1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: Cdkn2atm1Rdp/Cdkn2a+,Nf1tm1Tyj/Nf1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Nf1tm1Par/Nf1tm1Par
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002031 adrenal tumor "tumors of the adrenal gland, including phaeochomocytomas" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Nf1tm1Par/Nf1tm1Par
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002033 malignant triton tumors " malignant tumor with neurogenic and myogenic differentiation; usually arises in tissues of neural crest origin" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0002035 leiomyosarcoma "malignant tumor derived from smooth (nonstriated) muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0002036 rhabdomyosarcoma "malignant tumor derived from skeletal (striated) muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Nf1tm1Par/Nf1tm1Par
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002037 fibrohistocytoma "slowly growing skin nodule derived from cellular fibrous tissue; often surrounds capillaries" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0002039 neuroblastoma "malignant neoplasm characterized by immature nerve cells of embryonic type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1+,Tg(Th-MYCN)41Waw/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002050 pheochromocytoma "a benign neoplasm derived from adrenal medullary cells; usually associated with hypertension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Nf1tm1Par/Nf1tm1Par,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Tyj/?,Trp53tm1Tyj/?,Mastr129S4/SvJae/?
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J

Allelic Composition: Nf1tm1Tyj/?,Nstr1A/J/?,Trp53tm1Tyj/?
Genetic Background: involves: 129S2/SvPas * A/J * C57BL/6J

Allelic Composition: Nf1tm1Tyj/?,Nstr2A/J/?,Trp53tm1Tyj/?
Genetic Background: involves: 129S2/SvPas * A/J * C57BL/6J

Allelic Composition: Nf1tm1Fcr/Nf1+,Tg(Cnp-EGFR)10Nrat/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Egfrwa2/Egfr+,Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * C57BL/6JEi * C3H/HeSnJ

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Tyj/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Trp53tm1Elee/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Elee/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Nf1tm1Par/Nf1tm1Tyj,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Nf1tm1Tyj/Nf1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Nf1tm1Fcr/Nf1tm1Fcr,Trp53tm1Elee/Trp53tm1Elee,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * FVB/N

Allelic Composition: Lrrc17tm1Nik/Lrrc17+,Nf1tm1Par/Nf1tm1Par,Srpk2tm1Nik/Srpk2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Nf1tm1Par/Nf1+,Trp53tm1Tyj/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Tyj/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Trp53tm1Elee/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Elee/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (C3H/HeJ x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (CAST/EiJ x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

Allelic Composition: Nf1tm1Fcr/Nf1+,Tsc1tm1Djk/Tsc1tm1Djk,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: F7tm1Pec/F7tm1Pec,Tfpitm1Gjb/Tfpitm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1tm2Tyj
Genetic Background: chimera involves: 129S2/SvPas

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Tyj/Nf1tm2Tyj
Genetic Background: chimera involves: 129S2/SvPas

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Nf1tm1Par/Nf1+,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Nf1tm1Par/Nf1tm1Fcr,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,TcrbLn3Jae/Tcrb+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1+,Pak1tm1Cher/Pak1tm1Cher
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002725 abnormal vein morphology "malformation of the blood vessels that carry blood towards the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002740 heart hypoplasia "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002752 abnormal somatic nervous system morphology "malformation or absence of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Tg(Cnp-EGFR)10Nrat/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0002802 abnormal discrimination learning "defects in the ability to exhibit a differential response to different stimuli that is achieved by the reinforcement of the desired response for each particular stimulus" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Casrtm1Ces/Casr+
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0002877 abnormal melanocyte morphology "malformation of the cells that produce pigment " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002884 abnormal branchial arches "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myo5atm1a(KOMP)Wtsi/Myo5atm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Myo5atm1a(KOMP)Wtsi/Wtsi

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0002999 abnormal bone healing "defects in the restoration of integrity to bone after trauma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(Cdkn1c)Jfpa/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0003491 abnormal voluntary movement "anomalies in coordinated movements executed with a purpose and can be improved by learning and/or experience" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Nf1tm1Fcr/Nf1+,Tg(Cnp-EGFR)10Nrat/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003808 enlarged endocardial cushions "larger than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [mac:Megan A. Cassell, Mouse Genome Informatics Curator]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003816 abnormal pituitary gland development "malformation or incomplete differentiation of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:51160]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003834 abnormal adrenergic chromaffin cell morphology "malformation of the cells responsible for epinephrine and norepinephrine secretion" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Nf1tm1Par/Nf1tm1Par,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Rnf7Gt(XE423)Byg/Rnf7Gt(XE423)Byg
Genetic Background: involves: 129 * C57BL/6

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004087 abnormal muscle fiber morphology "malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0004232 decreased muscle weight "less than average muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0004309 absent otic vesicle "absence of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004556 enlarged allantois "increased size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0004573 absent limb buds "missing the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(Cdkn1c)Jfpa/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004987 abnormal osteoblast cell number "deviation from the average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(Cdkn1c)Jfpa/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0005120 decreased circulating growth hormone level "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sor+,Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005172 lack of eye pigmentation "visual organs are devoid of coloring pigment in relation to control animals, usually resulting in a red or pink color" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005361 small pituitary gland "reduced size of the pituitary gland, the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nf1tm1Par/Nf1tm1Fcr,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0005571 decreased lactate dehydrogenase level "less than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo5atm1a(KOMP)Wtsi/Myo5atm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Myo5atm1a(KOMP)Wtsi/Wtsi

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Efna2tm1Jgf/Efna2+,Efna5tm1Ddmo/Efna5+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Myo5atm1a(KOMP)Wtsi/Myo5atm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Myo5atm1a(KOMP)Wtsi/Wtsi

 MP:0005645 abnormal hypothalamus physiology "anomalous function of the ventral and medial region of the diencephalon forming the walls of the ventral half of the third ventricle, which is normally involved in the functions of the autonomic (visceral motor) nervous system and, through its vascular link with the anterior lobe of the pituitary gland, in endocrine mechanisms" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005646 abnormal pituitary gland physiology "anmalous function of this unpaired compound gland suspended from the base of the hypothalamus by a short extension of the infundibulum, the infundibular or pituitary stalk" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Rnf7Gt(XE423)Byg/Rnf7Gt(XE423)Byg
Genetic Background: involves: 129 * C57BL/6

 MP:0006107 abnormal atrioventricular canal morphology "malformation or anomaly in development of the common canal connecting the primordial atrium and ventricle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93610]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008067 retinal ganglion cell degeneration "degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Par/Nf1tm1Fcr,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008250 abnormal myeloid leukocyte morphology "any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008272 abnormal endochondral bone ossification "anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
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Allelic Composition: Gt(ROSA)26Sortm1(Cdkn1c)Jfpa/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008288 abnormal adrenal cortex morphology "any structural anomaly of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Nf1tm1Par/Nf1tm1Par,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008301 adrenal medulla hyperplasia "overdevelopment or increased size of the inner portion of the adrenal gland that consists mainly of chromaffin cells, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv

Allelic Composition: Nf1tm1Fcr/Nf1tm1Par,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0008302 thin adrenal cortex "reduced thickness of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Nf1tm1Par/Nf1tm1Par,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008321 small adenohypophysis "reduced size of the anterior part of the pituitary that secretes a variety of hormones" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sor+,Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Par,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0008764 increased mast cell degranulation "increase in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,TcrbLn3Jae/Tcrb+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Par/Nf1tm1Fcr,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Nf1tm1Par/Nf1tm1Par
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009277 brain tumor "presence of abnormal rapidly proliferating cells in the brain, usually in the form of a distinct mass" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Par/Nf1+,Trp53tm1Tyj/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Tyj/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Trp53tm1Elee/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Elee/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (C3H/HeJ x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (CAST/EiJ x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (CBA/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0009321 histiocytic sarcoma 
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Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0009406 decreased skeletal muscle fiber number "decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0009419 skeletal muscle fibrosis "formation of fibrous tissue within skeletal muscle as a result of repair or a reactive process" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0009460 skeletal muscle hypoplasia "underdevelopment or decreased size of the skeletal muscle, usually due an increased number of cells" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009770 abnormal optic chiasm morphology "an anomaly in the flattened quadrangular body that is the point of crossing of the fibers of the optic nerves" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Par/Nf1tm1Fcr,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009845 abnormal neural crest cell morphology "any structural anomaly of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and disperse to many peripheral locations to form various tissues of the adult" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lefty1tm1Sla/Lefty1tm1Sla
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Nf1tm1Par/Nf1tm1Tyj,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Nf1tm1Par/Nf1tm1Tyj,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA

 MP:0010050 hypermyelination "anomaly in the process by which myelin sheaths are formed and maintained around neurons resulting in increased myelin formation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Par/Nf1tm1Fcr,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0010160 increased oligodendrocyte number "greater number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MESH:A08.637.600, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0010264 increased hepatoma incidence "greater than the expected number of malignant tumors composed of neoplastic liver cells in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010277 increased astrocytoma incidence "greater than the expected number of tumors that arise from astrocytes, large neuroglia cells of nervous tissue, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Tyj/?,Trp53tm1Tyj/?,Mastr129S4/SvJae/?
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J

Allelic Composition: Nf1tm1Par/Nf1+,Trp53tm1Tyj/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Tyj/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Trp53tm1Elee/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Elee/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (C3H/HeJ x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (CAST/EiJ x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

 MP:0010278 increased glioma incidence "greater than the expected number of tumors that arise from glial cells, non-neuronal cells of the nervous tissue, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Fcr,Trp53tm1Elee/Trp53tm1Elee,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * FVB/N

Allelic Composition: Nf1tm1Par/Nf1tm1Fcr,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Nf1tm1Fcr/Nf1+,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Fcr,Trp53tm1Elee/Trp53tm1Elee,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * FVB/N

 MP:0010310 increased Schwannoma incidence "greater than the expected number of benign, encapsulated nerve sheath tumors composed of Schwann cells, in a specific population in a given time period; usually associated with a peripheral or cranial nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010314 increased neurofibroma incidence "greater than the expected number of benign, encapsulated nerve sheath tumors composed of Schwann cells, in a specific population in a given time period; proliferation is disordered and includes portions of nerve fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Par/Nf1tm1Tyj,Tg(Postn-cre)1Sjc/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Allelic Composition: Nf1tm1Tyj/Nf1tm2Tyj
Genetic Background: chimera involves: 129S2/SvPas

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010334 pleural effusion "accumulation of excess fluid in the pleural cavity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010361 increased gangliosarcoma incidence "greater than the expected number of a highly aggressive malignant neoplasm arising from mature ganglionic neurons, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Nf1tm1Par/Nf1tm1Par,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0010362 increased ganglioneuroma incidence "greater than the expected number of a benign neoplasm composed of mature ganglionic neurons in a given population in a given time period; cells may be scattered singly or in clumps within a relatively abundant and dense stroma of neurofibrils and collagenous fibers" [MPATH:375]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Nf1tm1Par/Nf1tm1Par,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0010363 increased fibrosarcoma incidence "greater than the expected number of a highly aggressive malignant neoplasm arising from fibrous connective tissue, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0010614 abnormal mitral valve cusp morphology "any structural anomaly of the two fibrous components and associated flaps of the mitral valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010727 increased glioblastoma incidence "greater than the expected number of a fast-growing type of central nervous system tumor that forms from glial tissue of the brain and spinal cord and has cells that look very different from normal cells; glioblastoma usually occurs in adults and affects the brain more often than the spinal cord" [NCI:CDRID45698 "http://www.cancer.gov/dictionary/?CdrID=45698"]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (C3H/HeJ x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (CAST/EiJ x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

 MP:0010924 abnormal osteoid morphology "any structural anomaly of newly formed organic bone matrix secreted by osteoblasts, that exists prior to calcification; it is comprised mainly of type I collagen fibers, chondroitin sulfate and osteocalcin" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gt(ROSA)26Sortm1(Cdkn1c)Jfpa/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010929 increased osteoid thickness "increase in the width of the layer of newly formed organic bone matrix secreted by osteoblasts" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gt(ROSA)26Sortm1(Cdkn1c)Jfpa/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010964 increased compact bone volume 
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Allelic Composition: Gt(ROSA)26Sortm1(Cdkn1c)Jfpa/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Nf1tm1Tyj/Nf1tm2Tyj
Genetic Background: chimera involves: 129S2/SvPas

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Par,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ext1tm1Yama/Ext1+,Slit2tm1Matl/Slit2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sor+,Nf1tm1Fcr/Nf1tm1Par,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Allelic Composition: Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv

 MP:0011180 abnormal hematopoietic cell number "any anomaly in the expected number of cells of the hematopoietic lineage" [CL:0000988, MGI:csmith]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011205 excessive folding of visceral yolk sac "the appearance of wrinkles or folds on the surface of the visceral yolk sac" [MGI:csmith, PMID:17881493]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0011276 increased tail pigmentation "visually detectable excess of pigment present on the tail surface" [MGI:csmith]
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Allelic Composition: Ext1tm1Yama/Ext1+,Slit2tm1Matl/Slit2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 * SJL

 MP:0011278 increased ear pigmentation "visually detectable excess of pigment present in the outer ear" [MGI:csmith]
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Allelic Composition: Ext1tm1Yama/Ext1+,Slit2tm1Matl/Slit2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 * SJL

 MP:0011364 abnormal metanephros morphology "any structural anomaly of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord; the metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine" [GO:0001656]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011746 spleen fibrosis "invasion of fibrous connective tissue into the spleen, often resulting from inflammation or injury" [MGI:csmith]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Par,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011808 abnormal myoblast differentiation "anomaly in the process in which a relatively unspecialized cell acquires specialized features of a myoblast, a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers" [GO:0045445]
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Allelic Composition: Nf1tm1Par/Nf1tm1Par,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0012087 absent midbrain "absence of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0012136 absent forebrain "absence of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0012261 increased hindbrain apoptosis "increase in the number of cells of the hindbrain undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0012415 decreased sarcoma incidence "less than the expected number of a connective tissue neoplasm associated with the proliferation of embryonically-derived mesodermal cells, occurring in a specific population in a given time period" [DOID:1115]
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Allelic Composition: Cpt1cGt(XL823)Byg/Cpt1c+,Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,Nf1tm1Tyj/Nf1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Nf1tm1Tyj/Nf1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Nf1tm1Tyj/Nf1+,Suz12Gt(Betageo)1Khe/Suz12+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0012761 increased cranial neural crest cell apoptosis "increased number of cranial neural crest cells (NCCs) undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0013693 abnormal hemopoiesis "any anomaly in the process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure; the site of hemopoiesis is variable during development, but occurs primarily in bone marrow in mammals" [GO:0030097]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0014049 increased T cell acute lymphoblastic leukemia incidence "an aggressive (fast-growing) type of leukemia (blood cancer) in which too many T-cell lymphoblasts (immature white blood cells) are found in the bone marrow and blood" [NCIT:C3183]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0020549 increased optic chiasm size "increased size of the optic chiasm" [MGI:smb]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027351 Q924S8 / Spred1 / Sprouty-related, EVH1 domain-containing protein 1 / Q7Z699* / sprouty related EVH1 domain containing 1*  / complex / reaction






 

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