ENSGALG00000028203


Gallus gallus

Features
Gene ID: ENSGALG00000028203
  
Biological name :SPRED1
  
Synonyms : SPRED1 / sprouty related EVH1 domain containing 1
  
Possible biological names infered from orthology : Q7Z699 / Q924S8 / Sprouty-related, EVH1 domain-containing protein 1
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 30752050
Gene end: 30805661
  
Corresponding Affymetrix probe sets: GgaAffx.23028.1.S1_at (Chicken Array)   GgaAffx.23028.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000042267
NCBI entrez gene - 423292     See in Manteia.
RefSeq - XM_015287346
RefSeq - NM_001199709
RefSeq - XM_015287344
RefSeq - XM_015287345
RefSeq Peptide - NP_001186638
swissprot - R4GJF3
Ensembl - ENSGALG00000028203
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spred1ENSDARG00000041449Danio rerio
 Q7Z699ENSG00000166068Homo sapiens
 Q924S8ENSMUSG00000027351Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SPRED2 / sprouty related EVH1 domain containing 2 / Q7Z698* / Q924S7* / Sprouty-related, EVH1 domain-containing protein 2 *ENSGALG0000000877857
EVL / ena/VASP-like protein / P70429* / Q9UI08* / Enah/Vasp-like*ENSGALG0000001120917
ENAH / ENAH, actin regulator / Q03173* / Q8N8S7*ENSGALG0000000930317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000697  WH1/EVH1 domain
 IPR007875  Sprouty
 IPR011993  PH-like domain superfamily
 IPR023337  c-Kit-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0010801 negative regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0010923 negative regulation of phosphatase activity IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0043409 negative regulation of MAPK cascade IEA
 biological_processGO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0060979 vasculogenesis involved in coronary vascular morphogenesis IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:0090311 regulation of protein deacetylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005173 stem cell factor receptor binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019902 phosphatase binding IEA
 molecular_functionGO:0030291 protein serine/threonine kinase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Regulation of RAS by GAPs
FGFRL1 modulation of FGFR1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000028203 SPRED1 / sprouty related EVH1 domain containing 1 / Q7Z699* / Q924S8* / Sprouty-related, EVH1 domain-containing protein 1 *  / complex






 

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