ENSMUSG00000045671


Mus musculus

Features
Gene ID: ENSMUSG00000045671
  
Biological name :Spred2
  
Synonyms : Q924S7 / Spred2 / Sprouty-related, EVH1 domain-containing protein 2
  
Possible biological names infered from orthology : Q7Z698 / sprouty related EVH1 domain containing 2
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A3.1
Gene start: 19924375
Gene end: 20024026
  
Corresponding Affymetrix probe sets: 10374455 (MoGene1.0st)   10374464 (MoGene1.0st)   1423001_at (Mouse Genome 430 2.0 Array)   1434403_at (Mouse Genome 430 2.0 Array)   1436892_at (Mouse Genome 430 2.0 Array)   1441802_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000090987
Ensembl peptide - ENSMUSP00000090988
Ensembl peptide - ENSMUSP00000115103
NCBI entrez gene - 114716     See in Manteia.
MGI - MGI:2150019
RefSeq - XM_006514458
RefSeq - NM_033523
RefSeq - XM_006514456
RefSeq - XM_006514457
RefSeq Peptide - NP_277058
swissprot - Q924S7
swissprot - Q5SRF8
swissprot - Q5SRF9
Ensembl - ENSMUSG00000045671
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spred2aENSDARG00000052435Danio rerio
 spred2bENSDARG00000008372Danio rerio
 SPRED2ENSGALG00000008778Gallus gallus
 Q7Z698ENSG00000198369Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q924S8 / Spred1 / Sprouty-related, EVH1 domain-containing protein 1 / Q7Z699* / sprouty related EVH1 domain containing 1*ENSMUSG0000002735156
Spred3 / sprouty related EVH1 domain containing 3 / Q2MJR0*ENSMUSG0000003723939
Enah / Q03173 / ENAH, actin regulator / Q8N8S7*ENSMUSG0000002299520
Evl / P70429 / Ena/VASP-like protein / Q9UI08* / Enah/Vasp-like*ENSMUSG0000002126218
Vasp / P70460 / vasodilator-stimulated phosphoprotein / P50552*ENSMUSG0000003040317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000697  WH1/EVH1 domain
 IPR007875  Sprouty
 IPR011993  PH-like domain superfamily
 IPR023337  c-Kit-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0010801 negative regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator IDA
 biological_processGO:0090311 regulation of protein deacetylation IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 molecular_functionGO:0005173 stem cell factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030291 protein serine/threonine kinase inhibitor activity IDA


Pathways (from Reactome)
Pathway description
Regulation of RAS by GAPs
FGFRL1 modulation of FGFR1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Chgatm1Skmt/Chga+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Chgatm1Skmt/Chga+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chgatm1Skmt/Chga+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Npc1m1N/Npc1m1N,Npc2tm1Plob/Npc2tm1Plob
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chgatm1Skmt/Chga+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Chgatm1Skmt/Chga+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Chgatm1Skmt/Chga+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Chgatm1Skmt/Chga+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Npc1m1N/Npc1m1N,Npc2tm1Plob/Npc2tm1Plob
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

Allelic Composition: Spred2Gt(XB228)Byg/Spred2Gt(XB228)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000008090 Fgfrl1 / Q91V87 / Fibroblast growth factor receptor-like 1 / Q8N441*  / reaction / complex
 ENSMUSG00000045671 Q924S7 / Spred2 / Sprouty-related, EVH1 domain-containing protein 2 / Q7Z698* / sprouty related EVH1 domain containing 2*  / complex






 

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