ENSG00000198369


Homo sapiens

Features
Gene ID: ENSG00000198369
  
Biological name :SPRED2
  
Synonyms : Q7Z698 / SPRED2 / sprouty related EVH1 domain containing 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p14
Gene start: 65310851
Gene end: 65432637
  
Corresponding Affymetrix probe sets: 212458_at (Human Genome U133 Plus 2.0 Array)   212466_at (Human Genome U133 Plus 2.0 Array)   214026_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000406481
Ensembl peptide - ENSP00000393697
Ensembl peptide - ENSP00000407627
Ensembl peptide - ENSP00000414551
Ensembl peptide - ENSP00000348753
Ensembl peptide - ENSP00000390595
Ensembl peptide - ENSP00000393148
NCBI entrez gene - 200734     See in Manteia.
OMIM - 609292
RefSeq - XM_005264202
RefSeq - NM_001128210
RefSeq - NM_181784
RefSeq - XM_005264200
RefSeq - XM_005264201
RefSeq Peptide - NP_001121682
RefSeq Peptide - NP_861449
swissprot - C9JG63
swissprot - H7C065
swissprot - H7C2T4
swissprot - Q7Z698
swissprot - H7C3Y6
swissprot - C9J623
Ensembl - ENSG00000198369
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spred2aENSDARG00000052435Danio rerio
 spred2bENSDARG00000008372Danio rerio
 SPRED2ENSGALG00000008778Gallus gallus
 Q924S7ENSMUSG00000045671Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q7Z699 / SPRED1 / sprouty related EVH1 domain containing 1ENSG0000016606855
Q2MJR0 / SPRED3 / sprouty related EVH1 domain containing 3ENSG0000018876637
ENAH / Q8N8S7 / ENAH, actin regulatorENSG0000015438018
VASP / P50552 / vasodilator stimulated phosphoproteinENSG0000012575318
EVL / Q9UI08 / Enah/Vasp-likeENSG0000019640517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000697  WH1/EVH1 domain
 IPR007875  Sprouty
 IPR011993  PH-like domain superfamily
 IPR023337  c-Kit-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway TAS
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0010801 negative regulation of peptidyl-threonine phosphorylation IMP
 biological_processGO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator ISS
 biological_processGO:0090311 regulation of protein deacetylation ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005173 stem cell factor receptor binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030291 protein serine/threonine kinase inhibitor activity ISS


Pathways (from Reactome)
Pathway description
Regulation of RAS by GAPs
FGFRL1 modulation of FGFR1 signaling
Signaling by RAS mutants


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000127418 FGFRL1 / Q8N441 / fibroblast growth factor receptor like 1  / reaction / complex
 ENSG00000198369 Q7Z698 / SPRED2 / sprouty related EVH1 domain containing 2  / complex






 

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