ENSG00000125753


Homo sapiens

Features
Gene ID: ENSG00000125753
  
Biological name :VASP
  
Synonyms : P50552 / vasodilator stimulated phosphoprotein / VASP
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.32
Gene start: 45506579
Gene end: 45526983
  
Corresponding Affymetrix probe sets: 202205_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000467061
Ensembl peptide - ENSP00000467005
Ensembl peptide - ENSP00000467773
Ensembl peptide - ENSP00000245932
Ensembl peptide - ENSP00000464742
Ensembl peptide - ENSP00000466319
NCBI entrez gene - 7408     See in Manteia.
OMIM - 601703
RefSeq - XM_017027200
RefSeq - NM_003370
RefSeq - XM_005259199
RefSeq - XM_005259200
RefSeq Peptide - NP_003361
swissprot - K7EQD0
swissprot - A0A024R0V4
swissprot - P50552
swissprot - K7EIG8
swissprot - K7EM16
swissprot - K7ENR7
swissprot - K7ENL7
Ensembl - ENSG00000125753
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vaspaENSDARG00000099690Danio rerio
 vaspbENSDARG00000017105Danio rerio
 VaspENSMUSG00000030403Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENAH / Q8N8S7 / ENAH, actin regulatorENSG0000015438051
EVL / Q9UI08 / Enah/Vasp-likeENSG0000019640548
Q7Z698 / SPRED2 / sprouty related EVH1 domain containing 2ENSG0000019836920
Q2MJR0 / SPRED3 / sprouty related EVH1 domain containing 3ENSG0000018876619
Q7Z699 / SPRED1 / sprouty related EVH1 domain containing 1ENSG0000016606817


Protein motifs (from Interpro)
Interpro ID Name
 IPR000697  WH1/EVH1 domain
 IPR011993  PH-like domain superfamily
 IPR014885  VASP tetramerisation
 IPR017354  Vasodilator-stimulated phosphoprotein/ENA/VASP-like
 IPR034367  Vasodilator-stimulated phosphoprotein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0008154 actin polymerization or depolymerization IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IDA
 biological_processGO:0034329 cell junction assembly TAS
 biological_processGO:0051289 protein homotetramerization IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0015629 actin cytoskeleton TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0031258 lamellipodium membrane IEA
 cellular_componentGO:0031527 filopodium membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005522 profilin binding IPI
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
Generation of second messenger molecules
Signaling by ROBO receptors
Cell-extracellular matrix interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000082074 FYB1 / O15117 / FYN binding protein 1  / complex / reaction
 ENSG00000162458 FBLIM1 / Q8WUP2 / filamin binding LIM protein 1  / complex / reaction
 ENSG00000043462 LCP2 / Q13094 / lymphocyte cytosolic protein 2  / reaction / complex
 ENSG00000145147 SLIT2 / O94813 / slit guidance ligand 2  / reaction / complex
 ENSG00000169855 ROBO1 / Q9Y6N7 / roundabout guidance receptor 1  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr