ENSG00000043462


Homo sapiens

Features
Gene ID: ENSG00000043462
  
Biological name :LCP2
  
Synonyms : LCP2 / lymphocyte cytosolic protein 2 / Q13094
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q35.1
Gene start: 170246237
Gene end: 170298227
  
Corresponding Affymetrix probe sets: 205269_at (Human Genome U133 Plus 2.0 Array)   205270_s_at (Human Genome U133 Plus 2.0 Array)   244251_at (Human Genome U133 Plus 2.0 Array)   244556_at (Human Genome U133 Plus 2.0 Array)   244578_at (Human Genome U133 Plus 2.0 Array)   244598_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000046794
Ensembl peptide - ENSP00000487460
Ensembl peptide - ENSP00000430391
Ensembl peptide - ENSP00000428871
NCBI entrez gene - 3937     See in Manteia.
OMIM - 601603
RefSeq - NM_005565
RefSeq Peptide - NP_005556
swissprot - E5RKA2
swissprot - A0A0D9SGG1
swissprot - E7ESF6
swissprot - Q13094
Ensembl - ENSG00000043462
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lcp2aENSDARG00000055955Danio rerio
 LCP2ENSGALG00000002113Gallus gallus
 Lcp2ENSMUSG00000002699Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BLNK / Q8WV28 / B cell linkerENSG0000009558522
CLNK / Q7Z7G1 / cytokine dependent hematopoietic cell linkerENSG0000010968418
SH2D6 / Q7Z4S9 / SH2 domain containing 6ENSG000001522927


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001660  Sterile alpha motif domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0045576 mast cell activation IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEP
 biological_processGO:0050663 cytokine secretion IEA
 biological_processGO:0050852 T cell receptor signaling pathway IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0036398 TCR signalosome IDA
 cellular_componentGO:0044853 plasma membrane raft IDA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Generation of second messenger molecules
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010610 CD4 / P01730 / CD4 molecule  / reaction
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / reaction / complex
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction / complex
 ENSG00000010671 BTK / Q06187 / Bruton tyrosine kinase  / complex / reaction
 ENSG00000158092 NCK1 / P16333 / NCK adaptor protein 1  / complex / reaction
 ENSG00000197943 PLCG2 / P16885 / phospholipase C gamma 2  / reaction / complex
 ENSG00000077264 PAK3 / O75914 / p21 (RAC1) activated kinase 3  / complex / reaction
 ENSG00000015285 WAS / P42768 / Wiskott-Aldrich syndrome  / complex / reaction
 ENSG00000043462 LCP2 / Q13094 / lymphocyte cytosolic protein 2  / reaction
 ENSG00000135605 TEC / P42680 / tec protein tyrosine kinase  / reaction / complex
 ENSG00000100351 GRAP2 / O75791 / GRB2-related adaptor protein 2  / complex / reaction
 ENSG00000213658 LAT / O43561 / linker for activation of T cells  / complex / reaction
 ENSG00000082074 FYB1 / O15117 / FYN binding protein 1  / complex / reaction
 ENSG00000160293 VAV2 / P52735 / vav guanine nucleotide exchange factor 2  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000113263 ITK / Q08881 / IL2 inducible T cell kinase  / complex / reaction
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / complex / reaction
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / complex / reaction
 ENSG00000134215 VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3  / complex / reaction
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / complex / reaction
 ENSG00000125753 VASP / P50552 / vasodilator stimulated phosphoprotein  / reaction / complex
 ENSG00000115085 ZAP70 / P43403 / zeta chain of T cell receptor associated protein kinase 70  / reaction
 ENSG00000167286 CD3D / P04234 / CD3d molecule  / reaction
 ENSG00000154380 ENAH / Q8N8S7 / ENAH, actin regulator  / reaction / complex
 ENSG00000160654 CD3G / P09693 / CD3g molecule  / reaction
 ENSG00000182866 LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase  / reaction
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / reaction
 ENSG00000198821 CD247 / P20963 / CD247 molecule  / reaction
 ENSG00000198851 CD3E / P07766 / CD3e molecule  / reaction
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / reaction
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / reaction
 ENSG00000211799 TRAV19 / T cell receptor alpha variable 19  / reaction
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr