ENSG00000158092


Homo sapiens

Features
Gene ID: ENSG00000158092
  
Biological name :NCK1
  
Synonyms : NCK1 / NCK adaptor protein 1 / P16333
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q22.3
Gene start: 136862208
Gene end: 136949823
  
Corresponding Affymetrix probe sets: 204725_s_at (Human Genome U133 Plus 2.0 Array)   211063_s_at (Human Genome U133 Plus 2.0 Array)   229895_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000417273
Ensembl peptide - ENSP00000419677
Ensembl peptide - ENSP00000419631
Ensembl peptide - ENSP00000419544
Ensembl peptide - ENSP00000419302
Ensembl peptide - ENSP00000418513
Ensembl peptide - ENSP00000418060
Ensembl peptide - ENSP00000417729
Ensembl peptide - ENSP00000288986
NCBI entrez gene - 4690     See in Manteia.
OMIM - 600508
RefSeq - NM_001291999
RefSeq - NM_006153
RefSeq - NM_001190796
RefSeq Peptide - NP_001177725
RefSeq Peptide - NP_001278928
RefSeq Peptide - NP_006144
swissprot - C9K098
swissprot - P16333
swissprot - C9JVV5
swissprot - C9JAB9
swissprot - C9J869
swissprot - C9J0K5
swissprot - A0A0S2Z4Y3
swissprot - H7C5C7
Ensembl - ENSG00000158092
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nck1aENSDARG00000074262Danio rerio
 nck1bENSDARG00000075369Danio rerio
 Nck1ENSMUSG00000032475Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NCK2 / O43639 / NCK adaptor protein 2ENSG0000007105169
GRAP / Q13588 / GRB2-related adaptor proteinENSG0000015401615
GRAP2 / O75791 / GRB2-related adaptor protein 2ENSG0000010035115
GRB2 / P62993 / growth factor receptor bound protein 2ENSG0000017788514
GRAPL / Q8TC17 / GRB2 related adaptor protein likeENSG0000018915211


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001452  SH3 domain
 IPR017304  Cytoplasmic protein NCK
 IPR035562  Nck1, SH3 domain 1
 IPR035564  Nck1, SH3 domain 2
 IPR035565  Nck1, SH3 domain 3
 IPR035882  Nck1, SH2 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006930 substrate-dependent cell migration, cell extension IEA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007172 signal complex assembly NAS
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030032 lamellipodium assembly IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IMP
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0036493 positive regulation of translation in response to endoplasmic reticulum stress IDA
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0042102 positive regulation of T cell proliferation IMP
 biological_processGO:0042110 T cell activation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IMP
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0051707 response to other organism IEA
 biological_processGO:0060548 negative regulation of cell death IDA
 biological_processGO:0070262 peptidyl-serine dephosphorylation IDA
 biological_processGO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IDA
 biological_processGO:1903676 positive regulation of cap-dependent translational initiation IDA
 biological_processGO:1903679 positive regulation of cap-independent translational initiation IDA
 biological_processGO:1903898 negative regulation of PERK-mediated unfolded protein response IDA
 biological_processGO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IDA
 biological_processGO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IDA
 cellular_componentGO:0000164 protein phosphatase type 1 complex IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005840 ribosome IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0012506 vesicle membrane IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IDA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity NAS
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008093 cytoskeletal adaptor activity NAS
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030159 receptor signaling complex scaffold activity NAS
 molecular_functionGO:0030674 protein binding, bridging IC
 molecular_functionGO:0030971 receptor tyrosine kinase binding IPI
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0046875 ephrin receptor binding IEA
 molecular_functionGO:0060090 molecular adaptor activity IPI
 molecular_functionGO:0071074 eukaryotic initiation factor eIF2 binding IPI


Pathways (from Reactome)
Pathway description
Downstream signal transduction
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
Nephrin family interactions
DCC mediated attractive signaling
Activation of RAC1
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000043462 LCP2 / Q13094 / lymphocyte cytosolic protein 2  / reaction / complex
 ENSG00000065320 NTN1 / O95631 / netrin 1  / complex / reaction
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / reaction / complex
 ENSG00000106299 WASL / O00401 / Wiskott-Aldrich syndrome like  / reaction / complex
 ENSG00000112715 VEGFA / P15692 / vascular endothelial growth factor A  / reaction / complex
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / reaction / complex
 ENSG00000134853 P16234 / PDGFRA / platelet derived growth factor receptor alpha  / complex / reaction
 ENSG00000113721 P09619 / PDGFRB / platelet derived growth factor receptor beta  / reaction / complex
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / complex / reaction
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000150760 DOCK1 / Q14185 / dedicator of cytokinesis 1  / complex / reaction
 ENSG00000171475 WIPF2 / Q8TF74 / WAS/WASL interacting protein family member 2  / reaction
 ENSG00000173210 ABLIM3 / O94929 / actin binding LIM protein family member 3  / reaction / complex
 ENSG00000100485 SOS2 / Q07890 / SOS Ras/Rho guanine nucleotide exchange factor 2  / reaction / complex
 ENSG00000115935 WIPF1 / O43516 / WAS/WASL interacting protein family member 1  / reaction
 ENSG00000122574 WIPF3 / A6NGB9 / WAS/WASL interacting protein family member 3  / reaction
 ENSG00000099204 ABLIM1 / O14639 / actin binding LIM protein 1  / reaction / complex
 ENSG00000015285 WAS / P42768 / Wiskott-Aldrich syndrome  / complex / reaction
 ENSG00000038382 TRIO / O75962 / trio Rho guanine nucleotide exchange factor  / reaction / complex
 ENSG00000077264 PAK3 / O75914 / p21 (RAC1) activated kinase 3  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction / complex
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / complex / reaction
 ENSG00000163995 ABLIM2 / Q6H8Q1 / actin binding LIM protein family member 2  / complex / reaction
 ENSG00000187323 DCC / P43146 / DCC netrin 1 receptor  / complex / reaction
 ENSG00000145147 SLIT2 / O94813 / slit guidance ligand 2  / reaction / complex
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / complex / reaction
 ENSG00000100311 PDGFB / P01127 / platelet derived growth factor subunit B  / complex / reaction
 ENSG00000197461 PDGFA / P04085 / platelet derived growth factor subunit A  / complex / reaction
 ENSG00000161270 NPHS1 / O60500 / NPHS1, nephrin  / reaction / complex
 ENSG00000183853 Q96J84 / KIRREL1 / kirre like nephrin family adhesion molecule 1  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000169855 ROBO1 / Q9Y6N7 / roundabout guidance receptor 1  / reaction / complex






 

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