ENSG00000122574


Homo sapiens

Features
Gene ID: ENSG00000122574
  
Biological name :WIPF3
  
Synonyms : A6NGB9 / WAS/WASL interacting protein family member 3 / WIPF3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: p14.3
Gene start: 29806486
Gene end: 29917066
  
Corresponding Affymetrix probe sets: 229849_at (Human Genome U133 Plus 2.0 Array)   232389_at (Human Genome U133 Plus 2.0 Array)   241600_at (Human Genome U133 Plus 2.0 Array)   241601_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000242140
Ensembl peptide - ENSP00000386878
Ensembl peptide - ENSP00000386790
NCBI entrez gene - 644150     See in Manteia.
OMIM - 612432
RefSeq - NM_001080529
RefSeq - XM_017012522
RefSeq Peptide - NP_001073998
swissprot - A6NGB9
swissprot - A0A0A0MSG0
Ensembl - ENSG00000122574
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sb:cb649ENSDARG00000036245Danio rerio
 WIPF3ENSGALG00000011170Gallus gallus
 Wipf3ENSMUSG00000086040Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WIPF2 / Q8TF74 / WAS/WASL interacting protein family member 2ENSG0000017147533


Protein motifs (from Interpro)
Interpro ID Name
 IPR003124  WH2 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0017124 SH3 domain binding IEA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases Activate WASPs and WAVEs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / reaction
 ENSG00000015285 WAS / P42768 / Wiskott-Aldrich syndrome  / reaction
 ENSG00000106299 WASL / O00401 / Wiskott-Aldrich syndrome like  / reaction
 ENSG00000158092 NCK1 / P16333 / NCK adaptor protein 1  / reaction
 ENSG00000213672 Q9NZQ3 / NCKIPSD / NCK interacting protein with SH3 domain  / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction






 

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