ENSMUSG00000086040


Mus musculus

Features
Gene ID: ENSMUSG00000086040
  
Biological name :Wipf3
  
Synonyms : WAS/WASL interacting protein family, member 3 / Wipf3
  
Possible biological names infered from orthology : A6NGB9
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B3
Gene start: 54429603
Gene end: 54503768
  
Corresponding Affymetrix probe sets: 10538377 (MoGene1.0st)   1455301_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132138
Ensembl peptide - ENSMUSP00000116325
Ensembl peptide - ENSMUSP00000120240
Ensembl peptide - ENSMUSP00000132022
NCBI entrez gene - 330319     See in Manteia.
MGI - MGI:3044681
RefSeq - XM_006506295
RefSeq - NM_001167861
RefSeq - XM_006506292
RefSeq - XM_006506293
RefSeq - XM_006506294
RefSeq - NM_001167860
RefSeq Peptide - NP_001161333
RefSeq Peptide - NP_001161332
swissprot - E9Q2D0
swissprot - D3Z5R4
Ensembl - ENSMUSG00000086040
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sb:cb649ENSDARG00000036245Danio rerio
 WIPF3ENSGALG00000011170Gallus gallus
 WIPF3ENSG00000122574Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wipf2 / Q6PEV3 / WAS/WASL interacting protein family, member 2 / Q8TF74*ENSMUSG0000003801333


Protein motifs (from Interpro)
Interpro ID Name
 IPR003124  WH2 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0017124 SH3 domain binding IEA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases Activate WASPs and WAVEs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0009235 small sperm head "reduced size of the head segment of the sperm cell" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: involves: 129P2/OlaHsd * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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